- Made Us Whole
Complete the game on any difficulty setting
- The Fugitive
Escape the Facility
- The Final Sacrifice
Destroy the Marker
01 February 2011 - 6 guides
- Cross your Heart, Hope to Die
Survive the Eye Poke Machine
01 February 2011 - 3 guides
- Necro Flambé
Kill 50 enemies using the Flamethrower
01 February 2011 - 2 guides
- Think Fast
Kill 30 Necromorphs with Kinesis objects
01 February 2011 - 4 guides
- Knock Knock
Complete the Drill Ride
- Looking good
Purchase the Advanced Suit
01 February 2011 - 3 guides
- The Librarian
Collect 100 logs
- Operation!
Snare the Shard with the Ishimura
- Picking favorites
Upgrade 1 Weapon completely
01 February 2011 - 4 guides
- The Sampler Platter
Kill a Necromorph with every Weapon in the game (single player only).
01 February 2011 - 3 guides
- Fully Outfitted
Upgrade your RIG and Stasis completely
31 January 2011 - 2 guides
- Shock Therapy
Impale an enemy with the Javelin Gun and use its Alt-Fire to shock 3 others (single player only)
31 January 2011 - 4 guides
- Hornet's Nest
Destroy the Tripod Nest
31 January 2011 - 2 guides
- Frozen in Time
Kill 50 Necromorphs while they are in Stasis (single player only)
31 January 2011 - 2 guides
- ...And Stay Down
Kill 25 crawling enemies with Stomp (single player only)
31 January 2011 - 6 guides
- Peek a Boo!
Kill a Stalker with the Seeker Rifle while in Zoom Mode
31 January 2011 - 6 guides
- The Electrician
Collect 10 Semiconductors
30 January 2011 - 2 guides
- C-Section
Knock down an enemy with Contact Beam Alt-Fire then kill it with Primary Fire before it stands up
30 January 2011 - 4 guides
- Lawnmower Man
Kill 4 enemies with the same Ripper blade
30 January 2011 - 5 guides
- Powered Up
Complete the Solar Array Puzzle
30 January 2011 - 2 guides
- Clean Cut
Sever all three tentacles of a Lurker with one Line Gun Primary Fire shot (single player only)
30 January 2011 - 3 guides
- Shut Down
Defeat the AI
- It's a Trap!
Kill 20 enemies with Detonator Mines in a deployed state
30 January 2011 - 5 guides
- Brute Juke
Kill a Brute without taking damage
30 January 2011 - 11 guides
- The Graduate
Win the fight at the School
30 January 2011 - 3 guides
- Going for Distance
Impale an enemy and make him fly through the air for 17 meters - it must stick to the surface
30 January 2011 - 8 guides
- Bouncing Betty
Kill a Cyst by catching its Mine and throwing it back
30 January 2011 - 7 guides
- The Engineer
Collect 10 Schematics
30 January 2011 - 3 guides
- Torment Me No More
Kill the Tormenter
- Clever Girls
Survive your first encounter with Stalkers
- One Small Step
Get through the first Zero-G area
- Lightspeed de Milo
Dismember the Lightspeed Boy Statue
28 January 2011 - 3 guides
- My Boom Stick
Kill 6 enemies at once with Line Gun's Alt-Fire (single player only)
28 January 2011 - 6 guides
- Derailed
Survive the Train Sequence
28 January 2011 - 2 guides
- Romper Stomper
Stomp 10 Containers
26 January 2011 - 2 guides
- First Aid
Use Quick Heal ten times (single player only)
- Patient on the Loose
Get your first Suit
- Shoot the Limbs!
Dismember 25 Necromorph Limbs (single player only)
26 January 2011 - 4 guides
- Taste of your own Medicine
TK Impale a live Slasher to a surface using a Slasher's arm - it must stick to the surface
26 January 2011 - 5 guides
- Elevator Action
Knock off every Tripod during the Elevator Sequence
Locked - 8 guides
- Mission Impossible
Complete the game on Zealot setting
Locked - 5 guides
- Vacuum Cleaner
Decompress 20 Necromorphs without getting sucked out yourself
Locked - 2 guides
- The Nanny
Kill 30 Crawlers without detonating them
Locked - 5 guides
- Epic Dismemberment
Dismember 2,500 Necromorph Limbs (single player only)
Locked - 7 guides
- Fully Loaded
Simultaneously have four completely upgraded weapons
Locked - 4 guides
- Collect Peng
Find the Peng treasure
Locked - 3 guides
- Skewered in Space
Impale an enemy into a Decompression Window to cause it to blow out
- Hard to the Core
Complete the game on Hard Core setting
Locked - 13 guides