Full list of all 50 Deadpool achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Completed "Landed in Prison"
Heh heh, good times
Stealth Killed Sinister, in the Prison, with the Sword!
Got a stealth kill with every melee weapon in Sinister’s Lair without being detected
Got through Toxic River without falling into or touching the water and taking damage
Interacted with all the ladies at the Shower Surprise Party room.
In "Genosha," reached the fan girl using only Hammers and Pulse Rifles
Completed "Genosha"
Banked a 300-hit combo
Shot everything from the Wheel of Insanity (Balloons and the Cow)
Killed 4 enemies in the Tower Plaza with stealth kills
Collected 100 tacos
Played WTF is Cable
Slapped Wolverine a bunch of times
Got from the studio lobby to the boardroom without dying in 5 minutes
Completed "Taking A Chance"
Used all three switches, defeated the two phasers, and chased after Vertigo within 60 seconds
Defeated Arclight while taking no damage from her slam attacks
Completed "Job One"
Scored a combo higher than 40 before they locked the elevators
Set the Dialog Volume slider to zero
Played with Deadpool's junk
Made a thousand pancakes
Was pretty
Got off your well-toned bottom
Take no damage on the waterslide
Get a high score at the Carnival
Find 11 treasure chests in the darkness of the Tombs
Beat "Death, Baby" while wearing the pirate hat
Choose the patience option all the way through the line in the Carnival
Complete "Death, Baby"
Collect all DP points and ammo in the bathroom
Shoot up the copier in the bridge offices
Complete the Breach in 10 seconds
Complete "The Road to Victory"
Make it across the floating debris without falling
Complete "Front Gates of EEEEEEEVIL!" from start to finish without dying
Score a combo of 75 or more while fighting up the stairs at the "Front Gates of EEEEEEEVIL!"
Die 10 times in a row through the floating stairs
Complete "Front Gates of EEEEEEEVIL!"
Complete "Front Gates of EEEEEEEVIL!" from start to finish using only swords and pistols
Complete the game on Veteran difficulty
Complete the game on Ultra-Violence! difficulty
Complete "Landed in Prison" without countering any attacks
Purchase all Player Upgrades
Complete five Gold Challenges
Complete a Gold- or Silver-tier Challenge while countering at least 25 times
Combo an entire wave on any Gold-tier Challenge map
Kill a total of 15 enemies by holding cooked grenades
Upgrade all weapons to max