Full list of all 72 Fallout 3 achievements worth 1,550 gamerscore. It takes around 60-80 hours to unlock all of the achievements in the base game on Xbox 360.
The base game contains 50 achievements worth 1,000 Gamerscore, and there are 5 DLC packs containing 22 achievements worth 550 Gamerscore.
Got the Pip-Boy 3000
Took the G.O.A.T.
Completed "Escape!"
Completed "Following in His Footsteps"
Completed "Galaxy News Radio"
Completed "Scientific Pursuits"
Completed "Tranquility Lane"
Completed "The Waters of Life"
Completed "Picking up the Trail"
Completed "Rescue from Paradise"
Completed "Finding the Garden of Eden"
Completed "The American Dream"
Completed "Take it Back!"
Completed "The Wasteland Survival Guide"
Completed "The Nuka-Cola Challenge"
Completed "The Replicated Man"
Completed "Oasis"
Completed "The Power of the Atom"
Completed "Tenpenny Tower"
Completed "Strictly Business"
Completed "Reilly's Rangers"
Reached Level 8 with Bad Karma
Killed 300 creatures
Picked 50 locks
Discovered 100 locations
Placed a grenade or mine while pickpocketing
Completed "You Gotta Shoot 'Em in the Head"
Completed "Blood Ties"
Completed "Stealing Independence"
Completed "Trouble on the Homefront"
Completed "Agatha's Song"
Completed "Those!"
Reached Level 20 with Bad Karma
Killed 300 people
Reached Level 14 with Bad Karma
Completed "Head of State"
Completed "The Superhuman Gambit"
Completed "Big Trouble in Big Town"
Reached Level 8 with Neutral Karma
Reached Level 8 with Good Karma
Reached Level 14 with Neutral Karma
Reached Level 14 with Good Karma
Reached Level 20 with Neutral Karma
Reached Level 20 with Good Karma
Made one of every custom weapon
Won 50 Speech Challenges
Hacked 50 terminals
Kill all the Super Mutant Behemoths
Collected 10 Vault-Tec Bobbleheads
Collected 20 Vault-Tec Bobbleheads
Completed "Operation: Anchorage"
Completed "Paving the Way"
Completed "The Guns of Anchorage"
Completed "Aiding the Outcasts"
Completed "Into The Pitt"
Found All 100 Steel Ingots
Completed "Free Labor"
Completed "Unsafe Working Conditions"
Completed "Death From Above"
Completed "Shock Value"
Completed "Who Dares Wins"
Reached Level 30 with Bad Karma
Reached Level 30 with Neutral Karma
Reached Level 30 with Good Karma
Completed "Walking With Spirits"
Discovered all locations within Point Lookout
Completed "A Meeting of the Minds"
Completed "The Local Flavor"
Completed "This Galaxy Ain't Big Enough…"
Completed "Among the Stars"
Completed "Not of This World"
Collected all Alien Captive Recordings