Full list of all 84 Fallout 4 achievements worth 1,600 gamerscore. It takes around 80-100 hours to unlock all of the achievements in the base game on Xbox One.
The base game contains 50 achievements worth 1,000 Gamerscore, and there are 6 DLC packs containing 34 achievements worth 600 Gamerscore.
Reach Level 50
Reach Maximum Happiness in a Large Settlement
Complete 50 Misc. Objectives
Collect 20 Vault-Tec Bobbleheads
Complete "Ad Victoriam"
Complete "Blind Betrayal"
Complete "Nuclear Family"
Complete "The Nuclear Option"
Decide the Fate of the Commonwealth
Complete "Rockets' Red Glare"
Complete "Underground Undercover"
Complete "Powering Up"
Hack 50 Terminals
Collect 10 Vault-Tec Bobbleheads
Complete "Mankind-Redefined"
Reach Maximum Relationship Level with a Companion
Complete "Institutionalized"
Complete "The Molecular Level"
Complete "Hunter/Hunted"
Kill 5 Giant Creatures
Kill 300 People
Craft 100 Items
Complete 10 Side Quests
Pick 50 Locks
Read 20 Magazines
Complete "Dangerous Minds"
Reach Level 25
Create 50 Weapon Mods
Kill 300 Creatures
Discover 100 Locations
Complete "Old Guns"
Gather 1000 Resources Used For Crafting
Recruit 5 Separate Companions
Complete "Reunions"
Complete "Taking Independence"
Build 100 Workshop Items
Complete "Unlikely Valentine"
Join the Railroad
Complete "Sanctuary"
Reach Level 10
Get a Touchdown
Get a Homerun
Join the Brotherhood of Steel
Ally with 3 Settlements
Placed A Grenade Or Mine While Pickpocketing
Join the Minutemen
Reach Level 5
Complete "When Freedom Calls"
Enter The Wasteland
Play a Holotape Game
Complete "Restoring Order"
Build 10 Robot Mods
Complete "Headhunting"
Unlock 10 Robot Mods
Complete "Mechanical Menace"
Have 5 Tamed Creatures in a Settlement
Build One of Every Cage Type
Start a Spectated Arena Fight in a Settlement
Complete the quest "Close to Home"
Complete the quest "Cleansing the Land"
Defeat 30 Far Harbor Sea Creatures
Unlock 3 Far Harbor Workshop Locations
Discover 20 Far Harbor Locations
Collect all issues of "The Islander's Almanac" magazine
Cook One of the New Far Harbor Recipes
Complete the quest "The Way Life Should Be"
Complete the quest "Where You Belong"
Complete the quest "Far From Home"
Produce 100 objects from your builders
Display a weapon on a weapon rack, armor on an armor rack, and power armor in a power armor display.
Assign a settler to a pillory
Become Overseer
Equip Vault 88 suit and Pip-Boy on a settler
Unlock all Vault 88 build areas
Redeem 100,000 tickets at the Nuka-Cade
Create 20 different flavors of Nuka-Cola
Collect every issue of Scav! Magazine
Complete "Power Play"
Establish 8 Raider Camps in the Commonwealth
Complete "Home Sweet Home"
Complete "The Grand Tour"
Defeat 40 Nuka-World Creatures while under the effect of any Nuka-Mix flavor
Complete 12 quests for any Nuka-World Raider Gangs
Complete "Taken for a Ride"