Full list of all 37 Marvel Heroes Omega achievements worth 1,030 gamerscore. It takes around 80-100 hours to unlock all of the achievements in the base game.
The base game contains 35 achievements worth 1,000 Gamerscore, and there is 1 DLC packs containing 2 achievements worth 30 Gamerscore.
Defeat Green Goblin in the Prologue
Defeat Doctor Octopus in Chapter 1
Defeat The Hood in Chapter 2.
Defeat Elektra in Chapter 3.
Defeat The Kingpin in Chapter 4.
Defeat Juggernaut in Chapter 5.
Defeat Magneto in Chapter 6.
Defeat Mister Sinister in Chapter 7.
Defeat Doctor Doom in Chapter 8.
Defeat Loki in Chapter 9.
Loot 1,000,000 Credits.
Find and Defeat a Cosmic Doop
Visit Six Different Headquarters
Defeat a Training Room Target Dummy.
Complete 14 Different Operations
Level any vendor to level 10.
Rescue 100 civilians in Midtown Patrol.
Collect any 100 Relics of the same type
Reach level 60 with any hero.
Explore all of the Treasure Rooms in each chapter of Story Missions.
Loot 100 Artifacts.
Complete the Super Heroic Trial with any hero.
Complete 25 Legendary Quests.
Apply a Modification to an Artifact.
Open 50 Bounty Chests in Operations
Fully upgrade a Legendary Item.
Defeat 150 Super Villains in Midtown Manhattan.
Loot a Cosmic Medallion
Defeat 7 Different Super Villians in their Showdowns
Complete 24 Different Special Events in Story Mode
Prestige any Hero.
Complete the Cosmic Trial with any hero.
Prestige any Hero twice.
Get Five Heroes to Level 60.
Earned all other Marvel Heroes Omega achievements.
Defeat 10 different members of the Sinister Six.
Alone, defeat Shocker in under 50 seconds upon entering the Abandoned Subway Operation.