Full list of all 37 Marvel Heroes Omega achievements worth 1,030 gamerscore. It takes around 80-100 hours to unlock all of the achievements in the base game.
The base game contains 35 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 2 achievements worth 30 Gamerscore.
Loot 100 Artifacts.
Get Five Heroes to Level 60.
Rescue 100 civilians in Midtown Patrol.
Level any vendor to level 10.
Collect any 100 Relics of the same type
Prestige any Hero twice.
Defeat Loki in Chapter 9.
Visit Six Different Headquarters
Defeat Doctor Doom in Chapter 8.
Defeat a Training Room Target Dummy.
Defeat 150 Super Villains in Midtown Manhattan.
Prestige any Hero.
Reach level 60 with any hero.
Defeat Mister Sinister in Chapter 7.
Complete 24 Different Special Events in Story Mode
Defeat Magneto in Chapter 6.
Defeat 7 Different Super Villians in their Showdowns
Defeat Juggernaut in Chapter 5.
Defeat The Kingpin in Chapter 4.
Defeat Elektra in Chapter 3.
Defeat The Hood in Chapter 2.
Defeat Doctor Octopus in Chapter 1
Defeat Green Goblin in the Prologue
Loot 1,000,000 Credits.
Find and Defeat a Cosmic Doop
Complete 14 Different Operations
Explore all of the Treasure Rooms in each chapter of Story Missions.
Complete the Super Heroic Trial with any hero.
Complete 25 Legendary Quests.
Apply a Modification to an Artifact.
Open 50 Bounty Chests in Operations
Fully upgrade a Legendary Item.
Loot a Cosmic Medallion
Complete the Cosmic Trial with any hero.
Earned all other Marvel Heroes Omega achievements.
Defeat 10 different members of the Sinister Six.
Alone, defeat Shocker in under 50 seconds upon entering the Abandoned Subway Operation.