Plague Inc: Evolved Walkthrough

3. Campaign

I have to give credit to where it is due, so I'd like give thanks to Yo, It's Spicy!, the Steam community, and the members of TA who took the time to write up strategies and solutions for many of these achievements. I couldn't have done this game or guide without content from each of these places. Most of what you see contained in this guide is a conglomeration of their work, with the order pieced together by myself.

Keep in mind that a LOT of this game focuses on RNG (Random Number Generation) in order for certain events to occur. That's why I recommend saving at certain parts, so you can keep reloading the save until the RNG Gods bless you with what you need. If you don't see a pop-up for a certain combo or event when I mention it, don't despair. There are a great many opportunities to unlock a lot of these achievements. Be sure to check the news ticker (cn_up) to be certain that a pop-up hasn't occurred.

When I tell you to evolve X or Y, those are always found in the evolution menu under symptoms, transmissions, or abilities. Symptoms are things your disease does to people, whether it be coughing and sneezing or total organ failure. Transmissions are vectors, ways your disease spreads. Those would be things such as Insect, Water, Rodent, Air, etc. Abilities are things that make your disease tougher and more adaptable, such as Cold, Heat, and Drug Resistance. After unlocking one of those, another tier may be available to purchase (II, III, etc).

When the game starts, the only disease type you'll have available is Bacteria. Start the game on casual. Since you don't have the additional genes unlocked, just play this game to get used to the way things operate and how it works. When the world is fully infected, save. Start evolving your kill symptoms now, (the ones that increase the "lethality" bar in the evolution screen) and wait until there are very few people left alive. At this point, save again. With that done, finish the game. You'll receive a gene for winning. Now, load that last save that you made. Keep waiting out for those last few people to die, ending the game. Each time, you'll get yourself another gene. This is by far the fastest and easiest way to unlock all of your genes, so we can get to the fun stuff.

With all the genes unlocked, start up a Bacteria run on Mega-Brutal. Use the following set up:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Now, start in China. Evolve Water and Insect I as soon as you possibly can. This will unlock:

Evolve your disease

Evolve your disease to become stronger

Evolve your disease
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Now when China gets pretty infected and you have amassed some points, evolve the following symptoms in the following order:

Cysts
Coughing
Nausea
Rash
Anemia
Vomiting

Now that coughing and vomiting have been combined, you may see a pop-up concerning the projectile vomiting combo and unlocking:

Long Shot

Discover the Projectile Vomiting combo

Long Shot
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Pneumonia
Sneezing
Sweating
Abscesses
Hyper Sensitivity
Hemophilia

After evolving hemophilia, you are likely to get a pop-up at some point stating that you discovered profuse bleeding, unlocking:

Red Rain

Discover the Profuse Bleeding combo

Red Rain
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Water II
Insect II

If China is fully infected and all the islands (Greenland, Iceland, Madagascar, Caribbean, Phillippines, etc) have their ports open, SAVE here. Now evolve:

Diarrhea

With diarrhea and sneezing added together, you can get the Oops symptom combo for:

Uh Oh

Discover the Oops symptom combo

Uh Oh
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Pulmonary Edema
Skin Lesions
Drug Resistance I
Bacterial Resilience I, II, and III

Now that you have some lethality and infected countries, you may get pop-ups about the Olympics and RMS watch list. These are random but appear very frequently, you will see them eventually and unlock:

Olympic Spoiler

Help the Olympics go viral in the UK

Olympic Spoiler
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RMS Watch List

Get your Plague on the RMS Watch List

RMS Watch List
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Drug Resistance II
Genetic Hardening I and II
Air I and II
Insomnia

With the insomnia added in to the anemia, the game may bless you with the walking dead combo and:

Brainzzzz

Discover the Waking Dead combo

Brainzzzz
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Paranoia
Seizures
Insanity
Necrosis
Paralysis

At this point, you may see a pop-up about a nuclear meltdown. This one is kinda tough and less likely on the RNG side of things, but you will get it eventually:

STALKERs delight

Cause a nuclear meltdown

STALKERs delight
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Coma

At this point, you should be a very lethal bacteria. If any of the islands close their ports before becoming infected, reload your save. Save again if the cure is low and all the islands are infected. Use your remaining points on Genetic Reshuffles when the cure rate starts to surpass 50%. Speaking of, popping your first blue cure bubble will net you:

Bottle Smasher

Smash a Blue cure bubble and slow down the Research Team

Bottle Smasher
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Once the game is complete, you'll unlock:

The End Plague

Win one game with any disease type and any difficulty

The End Plague
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Bacteria Master

Beat Bacteria on mega-brutal difficulty

Bacteria Master
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Bacteria Victory

Win a game with Bacteria on Normal Difficulty or higher

Bacteria Victory
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Now, start up another Bacteria run on casual with the following genes:

Cytochrome Surge
Genetic Mimic
Aerocyte
Xerophile
Translesion

Start in Saudi Arabia and evolve the following:

Rash
Sweating
Skin Lesions
Water I
Air I
Insect I
Drug Resistance I
Water II
Air II
Insect II
Cold Resistance I
Cold Resistance II
Coughing
Sneezing
Nausea
Vomiting
Genetic Hardening I
Necrosis
Diarrhea
Dysentery
Pulmonary Edema
Pulmonary Fibrosis
Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging

This should allow you to speed through the rest of the population, quickly infecting and killing everyone in under a year for:

Insane Bolt

Sprint to victory and set a world record by winning the game with Bacteria in under 365 days

Insane Bolt
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With all that out of the way, let's work on all the Bacteria combos. All of the following are done on Bacteria on casual difficulty. Start anywhere and use any genes with the following symptoms. After evolving them all, SAVE. Devolve any other symptoms that may mutate. Keep reloading the save until the achievement unlocks.

Blood I
Blood 2
Insect I
Insect 2
Extreme Hematophagy
Drug Resistance I and II

Eventually you will unlock:

Contaminated Package

Let humans spread the disease via blood transfusion

Contaminated Package
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Next game, set it up with the following genes:

ATP Boost
Creationist or Genetic Mimic
Aquacyte
Extremophile
Trans-Stasis

Start in India and evolve:

Water I
Air I
Water II
Air II
Extreme Bioaerosol
Livestock I
Livestock II
Cold Resistance I
Drug Resistance I
Cold Resistance II
Drug Resistance II
Genetic Hardening I
Genetic Hardening II
Coughing
Pneumonia
Nausea
Vomiting
Diarrhea
Insomnia
Sneezing

You should now unlock:

Oink oink

Discover the Swineflu Combo

Oink oink
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Now, use the following genes for this last combo:

Metabolic Jump
Genetic Mimic
Aerocyte
Xerophile
Sympto-Stasis

Start in India and evolve:

Blood I
Water I
Insect I
Bird I
Drug Resistance I
Genetic Hardening I
Coughing

Wait for a large portion of infection in India and accumulate at least 55 DNA points. After you get the points, SAVE. After saving, devolve all symptoms and evolve the following:

Insomnia
Paranoia
Seizures
Insanity
Dysentery
Diarrhea

Devolve dysentery, seizures, paranoia, and insomnia so that the only 2 symptoms remaining are insanity and diarrhea. Eventually, you'll get the pop-up and unlock:

Brown Streets

Discover the Public Defecation combo

Brown Streets
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Start up another game on Normal with any genes, beginning in China. Don't evolve anything, just simply wait until you see some news about the UK voting on "Brexit" in a referendum. If you don't see it before the UK becomes infected, restart. Once it does, make a save. Get the UK infected by evolving transmissions or simply waiting for the bacteria to reach the British Isles. Once it does, evolve:

Paranoia
Insomnia
Cold Resistance I and II

Devolve anything that comes up, then just wait until your bacteria triggers a "Soft Brexit" for:

Soft Brexit

Help Britain softly leave the EU

Soft Brexit
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Load up your save and infect the UK again. This time, evolve:

Insomnia
Paranoia
Cysts
Hypersensitivity
Cold Resistance I

Same deal, just wait things out a bit until you trigger "Hard Brexit" for:

Hard Brexit

Encourage Britain to have a 'hard' Brexit

Hard Brexit
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Now load the save, infect UK, and this time evolve:

Insomnia
Paranoia
Seizures
Insanity
Cysts
Hyper Sensitivity

Wait until the pop-up indicating a Brutal Brexit for:

Brutal Brexit

Put Britain on the road to madness when it leaves the EU

Brutal Brexit
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Last and least, load up the save again. Infect the UK and evolve:

Water I and II
Cold Resistance I and II
Rash
Sweating
Skin Lesions
Necrosis

Once the UK has been fully infected, Brexit will sadly be cancelled. This will give you:

No Brexit

Stop Britain leaving the EU

No Brexit
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With bacteria out of the way, time to move on to the next plague. Start up virus on Mega-Brutal with the following genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Water/Insect I

Nausea
Coughing
Rash
Cysts
Anemia
Vomiting
Pneumonia
Sneezing
Sweating
Hyper Sensitivity
Abscesses
Hemophilia
Water II
Insect II
Cold Resistance I
Heat Resistance I
Drug Resistance I
Cold Resistance II
Heat Resistance II
Drug Resistance II
Environmental Hardening
Diarrhea
Dysentery
Skin Lesions
Pulmonary Oedema
Necrosis
Genetic Hardening I
Genetic Hardening II
Insomnia
Paranoia
Seizures
Insanity
Paralysis
Coma

Keep evolving lethal/infectious symptoms until you win for:

Virus Master

Beat Virus disease type on mega-brutal difficulty

Virus Master
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Virus Victory

Win a game with Virus on Normal Difficulty or higher

Virus Victory
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Now moving onto fungus. Fungus is the most luck based pathogen in the entire game, and for good reason. Spreading on its own is incredibly slow, and utilizes its special spore ability to infect countries at random. Save before you use some, and just keep trying until you have lots of islands infected. Start fungus on Mega-Brutal with:

ATP Boost
Genetic Mimic
Suppression
Urbophile
Patho-Stasis

Start in Saudi Arabia and evolve:

Water I
Bird I
Water II
Cold Resistance I and II
Drug Resistance I
Heat Resistance I
Drug Resistance II
Spore Burst I, II, III, IV, V, VI
Spore Eruption
Genetic Hardening I and II
Rash
Sweating
Skin Lesions
Necrosis
Insomnia
Paranoia
Seizures
Cysts
Hyper Sensitivity
Paralysis
Coma
Coughing
Pneumonia
Bird II
Rodent I

SAVE now if you'd like, using the last spore bursts to infect the remaining islands.

Spore Burst I, II, III, IV, V, VI
Spore Eruption 2

As long as all of the islands are infected or at least have open ports, proceed on with...

Total Organ Failure
Genetic Reshuffle I, II, and III

Once everyone is dead, you shall unlock:

Fungus Master

Beat Fungus disease type on mega-brutal difficulty

Fungus Master
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Fungus Victory

Win a game with Fungus on Normal Difficulty or higher

Fungus Victory
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Next up is the Neurax Worm, the easiest disease type by far. Neurax has a completely different strategy to achieve easy victory, so get used to this setting. It will be used a LOT in scenarios. Use the following genes:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I

Trojan Planes are new to the Neurax plague, and are a life saver. Once enough of a country is infected, a plane icon pops up. Grab and place it above another country and let it go, automatically infecting that country. Always start with islands, moving onto any uninfected countries, and using the remainder on countries that need a little more infection in them. Start with the island countries, even a country without an airport can take a plane. Greenland, Iceland, Philippines, Caribbean, etc. Then shift focus onto any uninfected country, cure developers, and places that just need a little boost. Using your first plane will unlock:

Trojan Horse

Create a trojan plane and use it to infect a new country with the Neurax Worm

Trojan Horse
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Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Now just keep evolving transmissions until the world is infected, you don't need any more symptoms. Once the world is infected, you win. No killing necessary with Transcendence. This will get you:

Neurax Master

Beat Neurax Worm disease type on mega-brutal difficulty

Neurax Master
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Neurax Worm Victory

Win a game with Neurax Worm on Normal Difficulty or higher

Neurax Worm Victory
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Assuming Direct Control

Win a game by enslaving humanity with the Neurax Worm

Assuming Direct Control
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Start up another Neurax game, this time on casual with the following setup:

Metabolic Jump
Genetic Mimic
Aquacyte
Extremophile
Patho-Stasis

Start in India and evolve:

Concertina Locomotion
Neural Breach
Cerebral Tendrils
Frontal Mesh
Adrenergic Constriction
Anxiolytic Infusion
Psychosis
Cold, Heat, and Drug Resistance I and II
Environmental Hardening

Trojan Planes I

Speed things up until the infection becomes rapid, using the planes to infect remaining countries more quickly. Once most of the world is infected, evolve...

Despair
Suicide

This should get you:

Worm Food

Win a game by eradicating humanity with the Neurax Worm

Worm Food
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Next up is Parasite, start a Mega-Brutal game with these genes:

Metabolic Jump
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in Saudi Arabia and evolve:

Rash
Sweating
Skin Lesions
Water I
Insect I
Air I
Drug Resistance I
Water II
Air II
Fever
Insect II
Cold Resistance I and II
Genetic Hardening I
Coughing
Sneezing
Drug Resistance II
Pneumonia
Nausea
Vomiting
Pulmonary Fibrosis
Necrosis
Immune Suppression

Wait for a high amount of infection before evolving:

Total Organ Failure
Diarrhea
Pulmonary Edema
Dysentery
Genetic Reshuffle I, II, III (as necessary)
Insanity
Coma
Inflammation

This will earn you:

Parasite Master

Beat Parasite disease type on mega-brutal difficulty

Parasite Master
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Parasite Victory

Win a game with Parasite on Normal Difficulty or higher

Parasite Victory
3 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Moving on to the Prion. Since the Prion is very hard to detect but also slow moving, it makes it a tough win on Mega-Brutal but a perfect choice for a lot of the RNG encounters that may take some time to pop up for you. Let's get the hardest part out of the way first though, so fire up Prion on Mega-Brutal difficulty with:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Rash
Nausea
Coughing
Cysts
Anemia
Hemophilia
Hyper Sensitivity
Abscesses
Pneumonia
Sneezing
Sweating
Vomiting
Diarrhea
Skin Lesions
Water I
Insect I
Water II
Insect II
Drug Resistance I and II
Cold/Heat Resistance I and II
Insomnia
Paranoia
Seizures
Insanity
Paralysis
Coma
Neural Atrophy I, II, and III
Genetic Hardening I and II
Total Organ Failure

If the cure is progressing quickly, use Genetic Reshuffles until victory for:

Prion Master

Beat Prion disease type on mega-brutal difficulty

Prion Master
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Prion Victory

Win a game with Prion on Normal Difficulty or higher

Prion Victory
4 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Now, time to work some RNG magic. Begin Prion on casual, any genes you so desire. Start in Saudi Arabia and evolve:

Air I and II
Water I
Neural Atrophy I, II, and III
Drug Resistance I
Genetic Hardening I and II
Coughing
Sneezing
Pneumonia
Cysts
Hyper Sensitivity
Abscesses
Insomnia
Paranoia

Now the waiting game begins. SAVE here and devolve anything that may mutate, using Genetic Shuffles if the cure starts to creep up to 75% or higher. Wait until you see a pop-up saying "CDC teams hunt Patient Zero". That's the first phase. Shortly after this, you should get another pop-up saying that "CDC teams close in on Patient Zero". Once they're close to discovering them, evolve:

Anemia
Hemophilia
Internal Hemorrhaging
Hemorrhagic Shock

This is enough to kill people off at a fast enough rate to make discovery of Patient Zero impossible, but not destroy the world. After a few billion deaths, you should get the final pop-up stating that "The CDC failed to identify Patient Zero", unlocking:

Patient Who?

Stop the CDC finding Patient Zero

Patient Who?
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Now it's time to start tackling a few things at once. Begin a new game, Prion, on casual with the following genes:

Catalytic Switch
Genetic Mimic
Aerocyte
Extremophile
Sympto-Stasis

Start in the USA and evolve:

Drug Resistance I and II
Air I and II
Cold Resistance I
Water I and II
Extreme Bioaerosol
Neural Atrophy I,II and III
Genetic Hardening I and II

SAVE here, as this will create a divergent path where you can load the game and get multiple achievements without going back to evolve all that beginning stuff. Now, depending on whether you want the USA to nuke China or Russia, evolve either Bird I and II for China or Cold Resistance II for Russia. Accumulate 55 DNA points, then evolve:

Insomnia
Paranoia
Inflammation
Seizures
Insanity
Dysentery

You will see a pop up saying “iCure device announced”. Hold off until you see the 2nd pop-up announcing that "iCure device released globally". Once you have that, evolve sweating. Pretty soon you'll see a pop-up about how the touchscreens of the iCure are malfunctioning due to excessive sweating, unlocking:

Touchscreen Trash

Disrupt the iCure and stop it helping cure research

Touchscreen Trash
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After this, once things continue for a bit, you'll see a pop-up saying “Space cure mission planned”. Since everyone is pretty much already infected, just wait until you see the pop-ups announcing the launch and failure of the space cure mission. After the failure, you'll unlock:

Plague in Space

Infect astronauts before they launch a space mission

Plague in Space
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You will see pop-ups saying “US President taken ill”, followed by “New President of USA selected”. Depending on which evolution you chose after your save, you'll see “USA threatens Russia/China”. Now evolve insanity and paralysis. After a short period, you'll see Spalin nuked Russia/China because she was insane and the generals were paralyzed. Now simply reload your save, evolve the other ability, then continue on to nuke the other country for:

Russian Nuclear Retaliation

Make the USA nuke Russia

Russian Nuclear Retaliation
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Chinese Nuclear Retaliation

Make the USA nuke China

Chinese Nuclear Retaliation
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This last one is rather specific, and requires your disease to remain undetected the entire time. Start Prion on normal with the following genes:

Metabolic Hijack
Creationist
Native Biome
Hydrophile
Patho-Stasis

Start in the Caribbean, devolving any and all symptoms that may appear. Once your little island is fully infected, evolve nausea. Keep devolving all else, until you see "Rumors of mystery plague in Caribbean" appears. "Mystery Plague has been recommended to be investigated in Caribbean" should appear shortly after, followed by "Riots in Caribbean" a bit later on. This is what forces governments to intervene, ending with the final pop-up, "Mystery Plague is real" for:

Peer Pressure

Have your plague discovered after riots force a government investigation

Peer Pressure
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

With all of that out of the way, play through Necroa Virus on normal however you see fit. I have a whole section of this guide dedicated to the individual Necroa achievements, so do some practice runs of that scenario as experimentation to get used to the idea of playing with zombies. After evolving Cytopathic Reanimation, victims of the virus will start to turn into zombies. The special abilities opened up by zombies allow you to move hordes around and resurrect the dead. You can also evolve zombie combat abilities, making them deadlier and more difficult to kill. Once the entire world is almost dead, SAVE. Finish the game and get yourself a new zombie gene. Load that save a few more times to unlock all of the genes for Necroa, so that you are well prepared for the next section. After getting all of your genes, move on to Nano-Virus on Mega-Brutal difficulty with the following genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in Saudi Arabia and immediately evolve:

Code Fragment Interception
Coughing
Cysts
Hyper Sensitivity
Insomnia
Paranoia
Rash
Sweating
Nausea
Vomiting
Pneumonia
Sneezing
Abscesses
Aaemia
Hemophilia
Code Segment Interception
Water and Insect I
Paralysis
Coma
Skin Lesions
Diarrhoea
Water/Insect II
Radical Elements Stabilised
Drug Resistance I
Genetic Hardening I and II
Drug Resistance II
Seizures
Insanity
Cold Resistance I and II
Necrosis
Dysentery
Encryption Breached
Replication Factory Overload
Genetic Re-Shuffles I, II, and III
Heat Resistance I and II

Wait until you get the pop-up announcing "There are no healthy people left in the world". Once everyone is infected, start evolving Total Organ Failure and everything else that makes the lethality jump up high. Once almost everyone is dead, evolve Broadcast Interceptor Overload to keep the cure way down. Completing this will unlock:

Nano-Virus Master

Beat Nano-Virus disease type on mega-brutal difficulty

Nano-Virus Master
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Nano-Virus Victory

Win a game with Nano-Virus on Normal Difficulty or higher

Nano-Virus Victory
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Moving onto the next one, start up Bio-Weapon on Mega-Brutal with these genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Patho-Stasis

Begin your weapon in India and evolve:

Gene Compression I, II, and III
Deactivated Modified Genes I

If you start to kill people, evolve Deactivated Modified Genes II and III respectively.

Coughing
Pneumonia
Sneezing
Cysts
Hyper Sensitivity
Abscesses
Water/Air I and II
Extreme Bioaerosol
Drug Resistance I and II
Cold Resistance I and II
Heat Resistance I and II
Environmental Hardening
Genetic Hardening I and II
Nucleic Acid Neutralisation I, II, and III

Once everyone on earth is infected, Unlock Annihilation Gene and:

Genetic Reshuffles I, II, and III
Paralysis
Coma
Insomnia
Paranoia
Seizures
Insanity

Finishing here will unlock:

Bioweapon Master

Beat Bioweapon disease type on mega-brutal difficulty

Bioweapon Master
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Bio-Weapon Victory

Win a game with Bio-Weapon on Normal Difficulty or higher

Bio-Weapon Victory
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Now with that over with, you're going back to the learning phase again with the last virus, Simian Flu. There are 2 banks of genes to unlock here, so start up a run of this scenario, learning the new techniques and determining your preferred method of using apes to spread the infection.

I have a whole page on the specifics of this plague type, but in order to get through the first playthrough and unlock all the genes, using the following method. Start up a game on Casual and start your game in Saudi Arabia. From you'll want to evolve;

Pharyngitis
Sneezing
Air I and II
Drug Resistance I
Cold Resistance I
Water I and II
Extreme Bioaerosol
Drug Resistance II

From here, make a SAVE, then wait. Don't evolve anything else, and devolve anything you can up to costing 5 DNA points. Wait until the whole world is infected, although when the cure research reaches 25%, evolve Simian Neuro-Genesis and make another SAVE. Continue waiting for the world to be fully infected. Once it is, evolve the following;

Neuro-Enhancement I, II and III
Total Brain Death

After that, focus on evolving as many lethal symptoms as possible, especially the following;

Pulmonary Hemorrhage
Coma

Any remaining DNA you earn is to be spent on Genetic Reshuffles. Now simply wait until only a few thousand humans are left alive and make another SAVE, and let everyone die. Simply reload the save, rinse and repeat to unlock all the new Simian Flu genes. Then head to the Simian Flu page in this guide to work on the rest of the Simian achievements. You'll need to play through again on normal to unlock the following achievement:

Unlock Cheatmodes

Unlock the cheats by winning a game on Normal for ALL disease types

Unlock Cheatmodes
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Now that we have finished the base campaign, it's time to move onto the specific viruses.

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