Plague Inc: Evolved Walkthrough

5. Simian Flu

The Simian Flu is another virus that relies on the movement of infected hostile bodies in order to spread. This time we're using apes instead of zombies, but the same principles apply. The largest difference is that apes can create colonies that are essentially DNA factories. You're gonna be using this a lot, so make sure you're aware of the tactic. Start up your first game on casual with the genes:

ATP Boost
Ion Surge
Aquacyte
Extremophile
Together Strong

Devolve any symptom that mutates up until it costs 5 DNA to devolve, once you reach that point stop devolving. Devolving in the early stages will help you evade world governments and prevent them from taking action against your apes. This also reduces the chances of your one and only colony being destroyed by drones.

Start in Greenland, and evolve:

Simian Neuro-Genesis. This will soon unlock:

Great EscApe

Break apes out of the primate shelter

Great EscApe
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Ape Colonies. Base your colony in Greenland to unlock:

Family. Future.

Create an ape colony to bring intelligent apes together

Family. Future.
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Social Cohesion
Cognitive Shift
Education

SAVE

Water I and II
Air I and II
Extreme Bioaerosol
Drug Resistance I
Heat Resistance I
Primal Awareness
War Paint
Covert Expertise
Neuro-Enhancement I, II, and III
Total Brain Death
Photophobia
Subconjunctival Bleed
Subconjuctival Hemorrhage
Blindness

You will soon get a pop-up for this combo and:

Blind Genius

Discover the Blind Genius Combo

Blind Genius
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Meningitis
Coma
Hydrocephalus
Hypocoagulability

If you have spare DNA, go crazy on murder symptoms. Once everyone is dead, you shall unlock:

An Ape is for Life…

…Not just for Christmas

An Ape is for Life…
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Now start up another game on casual with the following genes:

ATP Boost
Ion Surge
Native Biome
Extremophile
Together Strong


Start in Central Africa and devolve any symptoms that mutate apart from what I mention. Evolve:

Simian Neuro-Genesis
Ape Colonies (start your colony in Central Africa)
Social Cohesion
Cognitive Shift
Education
Primal Awareness
War Paint
Cover Expertise

Wait until the number of apes in Central Africa reaches 400,000.

Ape Migration
Scouts
Path Finders

The other apes of the world will start to congregate in Central Africa. Wait for 500,000 to reach your colony to unlock:

Apes. Together. Strong.

Gather 500,000 apes in a single country

Apes. Together. Strong.
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Evolve Organized Travel and move your colony to East Africa for:

The Traveller

Move intelligent apes to a new country

The Traveller
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Now wait for the remainder of the worlds apes to become intelligent due to the virus for:

Not Just a Pretty Face

Make every ape in the world intelligent

Not Just a Pretty Face
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With every ape intelligent and infected, devolve Simian Neuro-Genesis. This will kill all the apes and grant you both:

Did I mean to do that?

Reverse Simian evolution

Did I mean to do that?
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Shouldn't Keep Pets

Allow all the apes to die

Shouldn't Keep Pets
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Start up another game on casual with these genes:

ATP Boost
Ion Surge
Teracyte
Extremophile
Together Strong

I started my Simian Flu in Central Africa, devolving anything that mutates and evolving:

Simian Neuro-Genesis
Ape Colonies
Social Cohesion
Cognitive Shift
Education

Establish colonies in the following countries as soon as they become available to farm as much DNA as possible.

  • West Africa
  • East Africa
  • Sudan
  • India
  • China
  • Indonesia

Evolve:

Primal Awareness
War Paint
Covert Expertise
Water/Air I and II

Now just sit and watch the world pass you by. Your apes will get destroyed by Gen-Sys and the military. Just allow this to happen, it's part of the plan. When a drone strike wipes out one of your colonies, you'll get:

Attack of the Drones

Have a colony destroyed by a drone

Attack of the Drones
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Just keep waiting for the plague to be cured, without apes retaliating and attacking humans. Once the cure is close to complete you'll get:

The Future is Bright

End the game with apes and humans living together peacefully

The Future is Bright
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Start up a game on Mega-Brutal with these genes:

ATP Boost
Ion Surge
Aquacyte
Extremophile
Together Strong

Start in Central Africa and evolve:

Simian Neuro-Genesis
Joint Pain
Ape Colonies (plant it in Central Africa)
Inter-Genus Dissemination I and II
Cognitive Shift
Education

Make 2 new colonies, one in East and one in West Africa.

Sebaceous Excretion
Blood Gift
Cutaneous Transfer
Submissive Conception
Excrement
Social Cohesion

This combo will get you:

Do it like they do

Discover the Discovery Channel Combo

Do it like they do
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Make another 2 colonies, one in Sudan and the other in Angola.

Primal Awareness
War Paint
Covert Expertise
Drug/Cold Resistance I
Genetic Hardening I
Organized Travel
Logistics
Seafaring
Scouts

The introduction of scouts will unlock:

Rude Awakening

Discover the Rude Awakening Combo

Rude Awakening
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Send apes from Morocco to Brazil.

Ape Rampage

This combination will net you:

Ape's Creed

Discover the Assassin Combo

Ape's Creed
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Cold/Drug Resistance II

Create another colony in Egypt.

Genetic Hardening II

Wait for a pop-up stating that a new Gen-Sys lab is working on a cure. Once you see this, use Ape Rampage on the country where the Gen-Sys lab is located. This will destroy the lab, take some progress off the cure, and scare the local human population into attacking apes for:

Go Simian-faeces

Destroy a Gen-Sys lab

Go Simian-faeces
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ExterminApe

Scare humans into becoming hostile to apes

ExterminApe
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Homindae Bridge

This should get you:

Like flies round…

Discover the Fly Magnet Combo

Like flies round…
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Devolve joint pain and evolve:

Air/Water I and II
Extreme Bioaerosol
Primal Hunt
Photophobia
Subconjunctional Bleed
Subconjunctional Hemorrhage
Blindness

Use apes to infect any uninfected country. If there's still a lot of healthy humans left, evolve:

Blood I and II
Extreme Hemoaerosol

Once the world is heavily infected evolve:

Neuro-Enhancement I, II, and III
Total Brain Death
Hemorrhagic Shock
Internal Hemorrhaging
Meningitis

Use your remaining DNA to evolve lethal symptoms until victory, unlocking:

Simian Master

Beat the Simian Flu on mega-brutal difficulty

Simian Master
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Apes will Rise!

Destroy humanity with the Simian Flu and let the apes take over

Apes will Rise!
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Now for the real annoyance. This next achievement is incredibly finnicky, and will require multiple attempts, even if you're sure you "got" it. You need a hostile ape colony in the USA, as well as healthy humans in that country. The virus needs to be cured, but only after there are under 1.5 million humans left alive. Start a game on casual with:

ATP Boost
Ion Surge
Aquacyte
Extremophile
Together Strong

Start in the USA and devolve every symptom until the entire world is infected! Make sure to plan ahead and have enough DNA left every time you want to make an upgrade. You can tell exactly how much DNA you will need as it just goes up by one each time, starting at 0 for the first symptom devolution. Evolve:

Simian Neuro-Genesis
Ape Colonies also, then put a colony in the USA
Organized Travel

Now, while doing future upgrades, watch Mexico, you can highlight Mexico in Ape Mode and you can see as soon as there are any 'Smart' apes in Mexico. The moment you see any 'Smart' apes there, start sending them to these locations preferably in this order: New Zealand, New Guinea, Philippines, Japan, Madagascar, Finland, U.K., Iceland, Greenland, and then anywhere else that shows there are apes that aren't 'Smart' yet. Do NOT wait for Mexico to build up it's smart apes populatio as you won't be able to take advantage of Mexico to spread infected apes around the world as all the apes will leave.

Continue evolving:

Cognitive Shift
Education
Logistics
Seafaring
Horseback Riding
Social Cohesion
Primal Awareness
War Paint
Covert Expertise
Ape Rampage
Primal Hunt
Weapon Creation
Ape Migration
Scouts
Path Finders

As soon as your traveling Apes from Mexico get across to Africa, you should now be able to start placing colonies there. Place colonies in West Africa, Central Africa, East Africa, Sudan, India, China, and Indonesia in whatever order you can, just as soon as you can. If one of those countries doesn't have any infected apes to build a colony, you can just build a nearby colony then migrate to the target country. These upgrades are going to get expensive! My guess as to the DNA costs: 1st colony: 8 DNA; 2nd: 15 DNA; 3rd: 25 DNA; 4th: 40 DNA; 5th: 55 DNA; 6th: 75 DNA; 7th: 95 DNA; 8th: 130 DNA. Don't worry though, you're going to have a LOT of DNA; I had over 1300 DNA when I finished. If a drone targets a colony, move it out of harms way. Make sure you always have your USA colony moved back if necessary. Moving a colony to avoid a drone will grant you:

EvacuApe

Evade a drone attack

EvacuApe
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SAVE after placing your final colony. Evolve:

Air/Water I and II
Extreme Bioaerosol
Heat Resistance I
Drug Resistance I and II
Genetic Reshuffle I and II
Hardened Reshuffle

Be ready to destroy Gen-Sys labs! Rampage and destroy them as soon as they appear.

SAVE once the world is infected fully. Now evolve:

Neuro-Enhancement I, II, and III
Total Brain Death

What you're doing here is making the human's recognize they are dying, and need to cure the virus. Once the cure gets underway, or you start getting messages about countries falling apart, DEVOLVE any lethal symptoms! DN NOT KILL more than 2 billion people! Now, you wait. Watch the cure percentage climb slowly, immediately kill any Gen-Sys labs that show up with Rampage, and run away from Drones. You want the cure to get over 70%, possibly 80%, before the next phase.

SAVE once the cure hits 70%. At 80%, evolve all lethal symptoms minus coma. Wait it out a bit, until you have a cure above 70% and only 4 million living humans. Stop the timer and devolve all 3 Reshuffle abilities. Go back to the game, start the timer again, and make sure the cure jumps to 100%. If you've done it right, you should get a pop-up that says the cure is being distributed.

If luck is on your side, you'll unlock:

Film Fanatic

Recreate the setting of the Dawn of the Planet of the Apes film

Film Fanatic
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Start up another game on casual with:

ATP Boost
Ion Surge
Teracyte
Extremophile
Together Strong

Start in Saudi Arabia and evolve:

Simian Neuro-Genesis
Ape Colonies
Social Cohesion
Cognitive Shift
Education
Ape Rampage
Organized Travel

Place a colony in Saudi Arabia right away once you have Education and if your plague has spread. Now your focus in spreading the plague as fast as you can. Evolve the following while making sure your timeline doesn't pass 11 months from your start date to be safe and keep de-evolving all mutations but Neuro-Enhancement I and II:

Air I
Water I
Drug Resistance I
Cold I
Air II
Water II

By this point you should be close to 11 months from the start date. If you are low on DNA let it pile up now so you can prepare for the end of the month. If you have excess, evolve a few travel upgrades or Air/Water II. Bird I and Insect I don't hurt either. Keep in mind you need around 35 to 40 DNA to evolve all the way to Total Brian Death. Once you hit about 10 days before a year from the start date, evolve Neuro-Enhancement I, II, III, and Total Brian Death. Let it run for about 3-4 days in game time and then DE-EVOLVE Total Brain Death and Neuro-Enhancement III.

If you did this quick enough, not too many people died due to the upgrade and the cure should only just be starting. Evolve:

Air/Water II
Bird I
Insect I
Drug Resistance II
Cold Resistance II

Keep adding another 2 ape colonies to help speed up your DNA collection. Start upgrading your Ape Rampage attacks (Primal Hunt & Weapon Creation) and all your movement abilities (Logistics, Seafaring, & Horseback Riding).

Keep an eye on labs that are working on the cure and Rampage them to destroy the labs. Feel free to put some DNA points into Genetic Hardening I and II to help slow down the cure. Avoid drones and wait until you get the pop that says there is no healthy people left in the world. Now just upgrade Total Brain Death again and any other lethal symptom you can get your hands on while hunting down labs. Once the population dies off, pop goes:

No Idea

Evolve 'Total Brain Death' in the first year and win

No Idea
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Start another casual game with any genes, evolving the following symptoms:

Photophobia
Subconjunctival Bleed
Subconjunctival Hemorrhage
Neuro-Enhancement I, II, and III
Total Brain Death
Bat I and II
Blood I and II

You should soon get a combo pop-up and unlock:

Not Necroa

Discover the Zombie Panic Combo

Not Necroa
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Start up another casual game with any genes and evolve:

Simian Neuro-Genesis
Organised Travel
Logistics
Horseback Riding
Ape Rampage
Primal Hunt
Weapon Creation

This will earn you:

Red Ape Redemption

Discover the Red Ape Redemption Combo

Red Ape Redemption
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With that done, you should have finished up with the Simian Flu. Congratulations! Time to move onto Shadow Plague...

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