Plague Inc: Evolved Walkthrough

6. Shadow Plague

Shadow Plague is the latest update to the game, introducing a new pathogen and a few Brexit/President Trump themed news tickers in the base game pathogens. Shadow Plague is very easy, it plays similarly to Simian Flu in the sense that you can build colonies and move infection vectors around in order to spread your disease, but it's much easier to accumulate tons of DNA in Shadow Plague.

First up, you need to do the usual process of unlocking all the Vampire-related genes by unlocking them from a save. In order to get that save, first load up game on Casual difficulty with the following genes:

Teracyte

Extremophile

Start your vampire in China and evolve the following genes;

Shadow Blessing

Blood Gift

Dark Cloud

Shadow Trail

Corrupted Air

Allow the game to continue. Within a few seconds, you should have a massive burst of infected countries to massively bolster the DNA you have in-hand. As soon as you can, unlock;

Therianthropy

This gives your vampire the ability to fly around the map, at a limited distance for now. Continue the game and wait for the message “Vampire feeding attracts attention in China”, then fly to India. when you start your first flight, you'll pop;

Batmobile

Transform vampire into a bat and fly somewhere

Batmobile
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Evolve the following when you have the points;

Night Wraith

Lair

Use lair to build a lair for yourself in India.

After your first lair is constructed, you'll earn;

Home Sweet Home

Set up a vampire lair

Home Sweet Home
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Once that is constructed, fly your vampire over to Saudi Arabia. Wait here until you’ve infected around 80% of the country, the fly on to Central Africa. Build a second lair here.

Use your DNA points to unlock;

Travel Speed 1

Travel Speed 2

Then fly to the western-most point of West Africa or to the most southernly point of Morocco, then from here to a northern point in Brazil (near the border to Colombia). Build your third lair here and wait for a few seconds until Argentina, Peru and Colombia are infected.

Fly to the USA (land on the East Coast) and wait until Canada and Mexico become infected (only takes a few seconds usually). From here, you’ll want fly to another series of countries, then wait for a few seconds in each country and infect the local countries, in the following order;

Greenland

Iceland

Sweden

UK

Spain

Germany

Ukraine

Turkey

While you’re batting about all over Scandinavia and Europe, you should be able to collect DNA from your lairs, orange DNA bubbles and infections. When you have the DNA, evolve the following;

Shadow Portal

Nocturnal

Anaemia

Pallor

Weeping Sores

Hyperdontia

Jugular Bite

Shadow Slaves

Once you land in Turkey, make another flight, via India, down into Oceania, landing in Australia first. Create your fourth lair here. Fly to the remaining countries around here to infect them (New Zealand, Philippines, New Guinea and Indonesia). You should also have enough DNA to evolve the following during your flights;

Blood Rage

Use cn_LS to activate your Blood Rage ability, which will give you a solid amount of DNA. This gives you:

Heart of Darkness

Send your vampire into a Blood Rage

Heart of Darkness
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Around now, you’ll probably get pop-ups stating that “Blood Cult leader has been tracked to (Insert country here)” and “Templar Industries alerts world to vampire threat” or something along those lines. Around here, my Vampire was spotted by humanity, which popped;

Twilight Lied

Let Humanity discover your vampire

Twilight Lied
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You’ll likely start seeing Templar Labs appear around the world, either fortresses that are being set up (that appear as a grey chemical flask) or that are fully set up (blue chemical flasks)

When the message “Templar Industries deems (your disease) a threat”, evolve;

Vampiric Awakening

Keep collecting DNA, while a good portion those infected die off in the hunt for another vampire. When you have the required DNA, evolve;

Lair Healing 1

Adrenal Surge

Keep collecting DNA. When you see the message “Templar Industries activate military protocols”, you’ll see countries with a little castle icon in them. These countries will become your main targets. To destroy them, fly to them and then use your Blood Rage ability in that country. Your vampire will go into combat with Templar Industries. Your health and their health are shown in the icons on the map (you’ll see the colour start to deplete from them). If you vampire gets too low, fly back to your nearest lair to start healing. You should be able to take out the fortresses as they pop up. Once the fortress is destroyed, fly back to any of your lairs to heal up.

When you destroy a Templar base, you'll pop;

Van Helsing's Doom

Destroy a Templar fort

Van Helsing's Doom
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As you earn more DNA, evolve the following as soon as you are able;

Lair Healing 2

Dark Infiltration

Shadow Blades

Demonic Fury

Around this time, you’ll also get a second vampire indicated by the message “New vampire created in (random country). Control this vampire and make them fly to any of your lairs to let them heal to full strength. When your vampire(s) are fully healed, fly them to each of the Templar countries and start destroying them with Blood Rage, then fly them back to a lair to let them heal.

During this fighting period, drones will also start targeting lairs. To stop this, send one vampire back to the lair the drone is targeting (it will start circling a country) and then use Blood Rage to destroy it. When the last Templar country is destroyed, you’ll see the notification “Templar forces eradicated”.

Now all that remains is to target the countries with labs that are trying to cure your disease. Fly your vampires to them and destroy them with Blood Rage. After destroying them all, send your vampires around to the remaining living countries and use Blood Rage to wipe out the remaining living people.

Remember, before you kill off everyone, make a save when the death of everyone on Earth is inevitable. Use this save to unlock all the vampire genes to be used later.

Head into the deep end now and start by loading up the game on Mega Brutal difficulty. Start with the following genes:

Harvester
Budget Bat
Aerocyte
Extremophile
Witch Doctor

Place your vampire in Greenland and evolve the following vampire traits:

Theriantrophy
Blood Rage

As soon as you're able to, evolve:

Dark Ritual I and II
Adrenal Surge

Continue to feed in Greenland until everyone in the country is dead and you begin to starve. Use your bat ability to now fly over to Iceland.

In Iceland, go back into Blood Rage. This time evolve:

Dark Infiltration
Shadow Blades
Demonic Fury

Stay in Iceland and eradicate it entirely, immediately flying to the nearest country with a Templar base immediately after. Use your Blood Rage on the country to destroy the Templar base.

Now go through and destroy more bases, saving before each one. Your health bar can be seen by zooming in on whichever country you are in, if the red portion in the box above the vampire is low, retreat from the country with the base and Blood Rage somewhere else to heal. As soon as you can, evolve:

Travel Speed I and II

This will allow you to travel faster and farther, making it easy to take out the remaining bases. If you ever need to retreat mid-battle against Templars, that's fine. Just heal up in a nearby country, then come back and attack before the Templar bases regain strength. If you get a message about your vampire being weak, but the base you're fighting is also low on health, try to tough it out. If you die, reload the save. If you destroy the base, you'll earn:

Luck of the Devil

Destroy a Templar fort with near death vampire

Luck of the Devil
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Now save again and fly to the nearest highly populated country and perform a Blood Rage. With the threat of Templars gone, you're free to consume as you please. Accumulate 550 DNA before saving again and proceeding on by evolving:

Lair
Shadow Portal

You'll want to strategically place these lairs, so travel to Australia, China, Ukraine, Central Africa, Brazil, and America and place a lair down. This will allow you to teleport instantaneously between any of them at will, making the next step much easier.

Placing multiple portals may grant you the Hellmouth Combo at some point, giving you:

Welcome to Hellmouth

Discover the Welcome to Hellmouth Combo

Welcome to Hellmouth
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Stay in America and feed until you get back to 550 DNA before moving to Egypt via your African lair. Once there, evolve:

Shadow Blessing
Blood Gift
Dark Cloud
Shadow Trail
Corrupted Air
Cold/Heat/Antibiotic Tolerance
Air I and II
Water I and II
Extreme Bioaerosal
Fomites I and II
Droplets I and II
Blood I and II
Zoonotic Shift
Bat I, II, and III
Wolf I and II
Dog I and II

This massive evolution allows you to infect a country thoroughly simply by traveling to it, so teleport between your lairs and fly out to surrounding islands that'd otherwise be a pain to infect. The cure will soon be underway, so travel to each lab and Blood Rage in the country. Save up your DNA and travel around, infecting and Blood Raging until the cure gets up to 70% or so. SAVE HERE. Start off by evolving:

Dark Pustules
Hypersensitivity
Malignant Pigmentation
Latent Adaptation
Pallor
Weeping Sores
Hyperdontia
Jugular Bite
Shadow Slaves

The creation of Shadow Slaves unlocks:

Blood Pets

Create slaves for your vampire

Blood Pets
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This will also make 2 combos available, unlocking:

Plague Dogs

Discover the Plague Dogs Combo

Plague Dogs
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Evil is a point of view

Discover the Evil is a point of view Combo

Evil is a point of view
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After a very short amount of time, you will enslave humanity and unlock:

Vampire Master

Beat Shadow Plague on mega-brutal difficulty

Vampire Master
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Load your previous save and evolve:

Dark Pustules
Hypersensitivity
Malignant Pigmentation
Latent Adaptation
Pallor
Weeping Sores
Hyperdontia
Jugular Bite
Steroidal Boost
Pheromone Secretion
Anabolic Boost
Hypocoagulability
Internal Hemorrhaging
Hemorrhagic Shock
Cranial Elephantitis
Autophagia
Vampiric Awakening

Some of these may take time, depending on how much DNA you've accumulated. This gives you the ability to unlock the following combos:

Uphill Ice Skating

Discover the Uphill Ice Skating Combo

Uphill Ice Skating
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Purity of the Chosen

Create a new vampire

Purity of the Chosen
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Essential Vitamins

Discover the Essential Vitamins Combo

Essential Vitamins
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If an infected host is chosen properly to create a new vampire, it unlocks:

Purity of the Chosen

Create a new vampire

Purity of the Chosen
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This will kill very quickly, so make sure you have a large portion of the globe infected before the evolution. Now go around and infect every country, destroy every lab, and Blood Rage to earn more DNA. If you succeed in destroying the world without evolving Shadow Slaves, you'll unlock:

Sadomasicist

Beat Shadow Plague with no Shadow Slaves

Sadomasicist
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Next, we will work on combos. If you run out of DNA and need to reload this save, feel free to do so at any point. Now load your save again and evolve:

Lair Healing I and II

This, in conjunction with your Bat transmissions, gives you:

Bat Cave

Discover the Bat Cave Combo

Bat Cave
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Now evolve:

Nocturnal
Steroidal Boost
Pheremone Secretion
Photophobia
Hyperdontia
Jugular Bite
Shadow Slaves
Muscular Hypotrophy
Masticatory Tension

This will grant you the ability to get the Carpe Jugulum combo and:

Carpe Jugulum

Discover the Carpe Jugulum Combo

Carpe Jugulum
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Evolve Night Wraith, which is the last ingredient needed in Silent but Deadly and Dark Night for:

Silent but Deadly

Discover the Silent but Deadly Combo

Silent but Deadly
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Dark Night

Discover the Dark Night Combo

Dark Night
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Next up, evolve:

Nocturnal
Anemia
Pallor
Weeping Sores
Photophobia
Hyperdontia
Jugular Bite
Shadow Slaves
Dermal Calcification

This will allow you to get:

Diamond Skin

Discover the Diamond Skin Combo

Diamond Skin
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From here, evolve Cranial Elephantitis and Malignant Pigmentation for:

Blood Trumps All

Discover the Blood Trumps All Combo

Blood Trumps All
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Now evolve Muscular Hypotrophy and Masticatory Tension for yet another combo and:

Dentist's Dream

Discover the Dentist's Dream Combo

Dentist's Dream
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Now evolve Anabolic Boost for this next combo:

Mr. Universe

Discover the Mr. Universe Combo

Mr. Universe
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That's it for combos! Now it's time to start a new game on Normal to work on an odd achievement, before getting into the tedious news items. Start in America and evolve Blood Rage, Lair and Theriantrophy immediately. Plant a lair before using Blood Rage and very carefully watch the number of people killed. You need to reach exactly 123 people killed in America. If you go over, restart. Once you hit 123 precisely, fly into Canada or Mexico and wait for:

Count Countula

Carefully count your vampire's feeds

Count Countula
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The news items come up randomly and in any order. The Shadow Pool event begins in Turkey, Stonehenge in the UK, and Dracula in Central Europe. If you want to force, for example, the Dracula event, you'll want to kill people in the UK and Turkey whilst staying out of Central Europe. Begin anywhere you like and travel from country to country quickly, before you attract the attention of the authorities or Templar forces. If you see something along the lines of "Blood cult blamed in (country) for killings", it's time to fly away. So pick in any country aside from the aforementioned three, evolve Night Wraith and Theriantrophy, then begin waiting for the pop-up. Restart or reload a save if nothing appears before 10 months have elapsed.

This can come up in any order, so feel free to jump around if you get a different order. I personally got Stonehenge first, which is initiated by a pop-up stating that an ancient chamber was discovered in Stonehenge. Shortly thereafter, you'll get a pop-up about a mutated skeleton being found in the passage. SAVE HERE. Now fly over to the UK and evolve your plague, being sure to evolve Steroidal Boost and Anabolic Boost. This will infect the UK, and when the tourists replace the stones you'll unlock:

Making Amends

Help tourists repair the damage to Stonehenge

Making Amends
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Now load up your save and evolve whatever symptoms you want, making sure to also evolve Water I and II as well as Air I and II. Once your disease is known to be infecting people, you'll get another message about the Stonehenge skeletons being infected with your disease. Save here once again, then fly into the UK and evolve Extreme Bioaerosal. Your next notification will be about the skeleton infecting the scientists, giving you:

Greyscale

Infect Stonehenge explorers

Greyscale
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Load up your last save and continue to evolve your disease, as well as doing some Blood Rage. Destroy any labs to slow the cure and battle any Templar forces, WITHOUT destroying them entirely. Eventually, you'll see a few news items relating to Stonehenge. What matters most is the pop-up indicating that the Templars plan on nuking Stonehenge since it is a high risk location. Once you see that, return to the UK and evolve both paths of Dark Ritual and whatever you can afford in Blood Rage before using it in the UK. This will give you a huge DNA boost as well as:

Power Overwhelming

Consume the bones at Stonehenge

Power Overwhelming
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That's the UK done, so for your next game start there. My next pop-up related to the Dracula story, which is about how a historian found an ancient map of Romania. Evolve Shadow Blessing and fly around until you see a pop-up stating that the historian states Dracula was real. SAVE HERE. Fly into Central Europe and evolve Dark Pustules, which will result in a humorous destruction of the map and:

Pus Explosion

Oooze pus everywhere!

Pus Explosion
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Load up your save and fly around, waiting for another pop-up stating that Dracula was real. Save here again, then evolve Zoonotic Shift and both Wolf transmissions before flying into Central Europe. The historian will be devoured by wolves and you'll unlock:

Wolf Pack

Hunt down historian searching for Dracula's tomb

Wolf Pack
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Load up your last save and a ton of news stories will pop up about Dracula, just wait until you see the one that states "Historian spots note about Dracula's return". Evolve Blood Rage, Lair, both sets of Lair Healing and fly into Central Europe. Perform a Blood Rage to bring Dracula back to life for:

I am your Father

Resurrect Count Dracula

I am your Father
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Now for the final news item. so start up another game and start in the UK. After killing someone there, fly to Central Europe and kill there. Now fly about until you see a pop-up about a cave system discovered in Turkey. Evolve Shadow Blessing and fly around until you get another pop-up about the Shadow Pool being discovered. SAVE HERE. Evolve Blood Rage and use it in Turkey, killing the cavers and giving you:

Rock Bottom

Consume the cavers exploring the Shadow Pool

Rock Bottom
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Load your save and continue flying around, leaving Turkey alone. until you get a pop-up about human remains being found near the Shadow Pool. Save again, then evolve Zoonotic Shift as well as all 3 Bat transmissions. Go into Turkey to infect it to let the bats kill the cavers for:

Chiroptophobia

Drive out cavers before sampling the Shadow Pool

Chiroptophobia
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Load your save and fly around until you get a news item about the Shadow Pool organisms being billions of years old. Use Blood Rage and evolve whatever symptom path you want up to Shadow Slaves. Infect Turkey and make sure it's fully infected by the time you are discovered by Templars. You'll get a final pop-up about the first vampire originating in the Shadow Pool, then quickly evolve Shadow Slaves and Muscular Hypertrophy. The Templars will be drowned in the pool by the Shadow Slaves, granting you:

Watery Grave

Drown Templar scientists in the Shadow Pool

Watery Grave
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That's the end of the Shadow Plague update!

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