Plague Inc: Evolved Walkthrough

7. Scenarios

Before we begin with the scenarios proper, time to utilize the cheatmodes we unlocked by beating every virus on Mega-Brutal. Start a new game up and activate the Shuffle Strain cheat, then choose Neurax Worm on Mega-Brutal using the genes:

ATP Boost
Base Hydrolysis
Native Biome
Extremophile
Trans-Stasis

Unfortunately, with shuffle strain, it's impossible to say what order to evolve in. Your main goals are to get a few transmissions, Trojan Planes I for sure, and Transcendence. With these evolved, focus on other transmissions and genetic reshuffles. Save once you've nearly wiped out all life. Once the world is destroyed, load up that save and let everyone die 4 more times and after this you'll unlock:

Normal Shuffle

Win 5 times in a row on normal difficulty with the shuffle strain enabled

Normal Shuffle
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Mega-Brutal Shuffle

Win 5 times in a row on mega-brutal difficulty with the shuffle strain enabled

Mega-Brutal Shuffle
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Fire up another game, this time swap out the shuffle strain for the Lucky-Dip strain in the cheats menu. Again, Neurax on Mega-Brutal with:

ATP Boost
Base Hydrolysis
Native Biome
Extremophile
Trans-Stasis

Since you have stuff evolved, you could be starting off strong. Follow this path:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Once everyone is infected, you will unlock:

Bingo!

Win 5 times in a row on normal difficulty with the lucky dip strain enabled

Bingo!
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Lottery Winner!

Win 5 times in a row on mega brutal difficulty with the lucky dip strain enabled

Lottery Winner!
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Now, let's get into the scenarios. Scenarios are situations in the game that have some pre-determined qualities, whether it's the starting country, disease, symptoms, or all of the above. For these achievements, you have to score a 3 Biohazard rating on these scenarios, which requires a certain score. Score is determined by cure percentage and time completed. From the menu you'll want to go into official scenarios, starting off with Black Death. Black Death starts you off as a bacteria with some new symptoms and transmissions. On casual, use the genes:

Catalytic Switch
Suppression
Genetic Mimic
Extremophile
Sympto-Stasis

Start in China and evolve:

Cysts
Flea II
Skin Lesions
Rodent I
Pneumonic Plague
Coughing
Sneezing
Drug Resistance I
Livestock I
Bird I
Cold Resistance I
Water I
Septic Plague
Abcesses
Nausea
Vomiting
Pulmonary Edema
Hemoptysis
Heat Resistance I
Drug Resistance II
Air I
Genetic Hardening I
Cold Resistance II
Heat Resistance II
Blood I
Diarrhea
Dysentery
Hypotension
Hemorrhagic Shock
Total Organ Failure
Hyper Sensitivity
Inflammation
Seizures
Paralysis

The key seems to be finishing in under a year with under 60% cure for maximum points. After scoring your 3 Biohazards, you'll unlock:

Complete Black Death

Score 3 biohazards with Black Death scenario

Complete Black Death
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next up is Created Equal. This time, your disease is spotted more easily, even in poor countries. Start up Neurax Worm on casual with the following genes:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold/Heat/Drug Resistance I and II

Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Focus on your transmissions now, evolving all of them. Take some points away to evolve your Reshuffles as you see fit. Once the world is infected and your 3 Biohazards are unlocked, you'll get:

Complete Created Equal

Score 3 biohazards with Created Equal scenario

Complete Created Equal
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Our next Scenario is Golden Age. In this one, the improved healthcare of the world makes infection harder to spread and easier to cure. We're once again using the Neurax on casual, with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Use the remaining DNA for transmissions, followed by reshuffles to maximize your score. After getting your points, you'll unlock:

Complete Golden Age

Score 3 biohazards with Golden Age scenario

Complete Golden Age
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Global Warming, so start Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

After scoring your bios, you'll unlock:

Complete Global Warming

Score 3 biohazards with Global Warming scenario

Complete Global Warming
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next, we have Ice Age. The overall global temperature has decreased, so cold resistance is gonna be used. Start up Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder
Mutative Regeneration 1 and 2
Trojan Planes 1
Cold Resistance 1 & 2

Drug Resistance 1 & 2
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Again, put your remaining points into transmissions and reshuffles to keep the cure low and infectivity high. After finishing with your 3 Bios, you'll get:

Complete Ice Age

Score 3 biohazards with Ice Age scenario

Complete Ice Age
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now, we have Mirror Earth. This is basically where everything is opposite. For example, East Africa is rich and cold while Canada is poor and hot. Same deal, Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold/Heat/Drug Resistance I and II

Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Same deal here, make use of your remaining DNA to increase infectivity and keep the cure as low as possible to score your biohazards and unlock:

Complete Mirror Earth

Score 3 biohazards with Mirror Earth scenario

Complete Mirror Earth
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The next one up is Pirate Plague. This one truly sucks. Water transmission is basically non-existent and can't really be relied upon. This is easy to overcome with Neurax, but everything else....I'm saving that for the next page. Neurax on normal with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Again, transmissions and reshuffles to keep your score up for:

Complete Pirate Plague

Score 3 biohazards in the Pirate Plague scenario

Complete Pirate Plague
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now we move onto Shut Down Everything, based on a meme created by the original Plague Inc and its sister game, Pandemic. A tough scenario, borders and ports are likely to get shut down very quickly. This is another one that requires all plagues, but for now we're doing Neurax on normal with:

ATP Boost
Darwinist
Suppression
Extremophile
Trans-Stasis

Start in India and evolve:

Eggs I and II
Concertia Locomotion

Uldolatery Locomotion
Genetic Swap
Rodent I
Insect I
Bird I
Air/Water I
Air II and III
Mutative Regeneration I and II
Trojan Planes I
Insect II
Bird II
Rodent II
Water II and III
Trojan Planes II and III
Cold Resistance I
Trojan Roamers I
Drug Resistance I and II
Trojan Roamers II
Cold Resistance II
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Transcendence

After this, you'll get:

Complete Shut Down Everything

Score 3 biohazards in the Shut Down Everything scenario

Complete Shut Down Everything
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The next one up is Smallpox, where you are given some smallpox to work with. Use the following genes:

ATP Boost
Darwinist
Aquacyte
Hydrophile
Trans-Stasis

Start in India and evolve:

Insect I
Fomites I
Vaccine Shield
Water I
Air I
Water II
Droplets II and III
Air II
Fomites II
Extreme Bioaerosol
Insect II
Cold Resistance I
Drug Resistance I
Cold Resistance II
Drug Resistance II
EJ2 Vaccine Shield
Livestock I and II
Genetic Hardening I
Corneal Ulceration
Genetic Hardening II
EJ7 Vaccine Shield
Blood I and II
Extreme Hematophagy
Genetic Reshuffle I
Necrosis
Coma
Genetic Reshuffle II and III

Once you win, you will be awarded:

Complete Smallpox

Score 3 biohazards with Smallpox scenario

Complete Smallpox
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Sovereign Default is next, in this scenario most countries are easier to infect and harder to spot your disease in, making things easier. Use the Neurax Worm on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Now use your DNA on, you guessed it, transmissions and reshuffles. After getting this one done, you'll unlock:

Complete Sovereign Default

Score 3 biohazards with Sovereign Default scenario

Complete Sovereign Default
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next is Swine Flu, you're given a virus here by default. Use the genes:

ATP Boost
Darwinist
Aquacyte
Hydrophile
Trans-Stasis

Start your disease in India and evolve:

Droplets II
Nausea
Rash
Swine II
Livestock I
Water I
Air I
Water II
Livestock II
Air II
Extreme Bioaerosol
Blood I and II
Cold Resistance I
Drug Resistance I
Cold Resistance II
Drug Resistance II
Bird I and II
Extreme Zoonosis
Historic Reassortment
Genetic Hardening I and II
Vomiting
Hyper Sensitivity
Diarrhea
Inflammation
Insomnia
Paranoia
Fatigue
Epistaxis
Hemoptysis
Pulmonary Hemorrhage

Finish up with your reshuffles to score your 3 bios and:

Complete Swine Flu

Score 3 biohazards with Swine Flu scenario

Complete Swine Flu
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Volcanic Ash is annoying, very similar to Pirate Plague. Only this time, air transmission is much less likely. Start on normal with Neurax and:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Use your Reshuffles to maximize your score and finish for:

Complete Volcanic Ash

Score 3 biohazards in the Volcanic Ash scenario

Complete Volcanic Ash
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Who Cares? is an interesting one. Poorer countries are less likely to identify and treat diseases so you can run rampant. As usual, choose Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

You know the deal, transmissions and reshuffles until a win:

Complete Who Cares

Score 3 biohazards with Who Cares scenario

Complete Who Cares
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Xenophobia is an interesting one, in which land borders start out more difficult to cross. This can easily be overcome with Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Heat/Cold/Drug Resistance I and II

Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Transmissions and reshuffles until:

Complete Xenophobia

Score 3 biohazards with Xenophobia scenario

Complete Xenophobia
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Unknown Origin is interesting, as you will start in a random country. Go with Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

This gets you:

Complete Unknown Origin

Score 3 biohazards with Unknown Origin scenario

Complete Unknown Origin
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now we finally get to switch things up a bit with Nipah Virus. There are some other miscellaneous achievements to do here, so let's start with those. Start it on casual with:

Metabolic Hijack
Genetic Mimic
Aquacyte
Extremophile
Translesion

Start anywhere and evolve:

Hendra
Horse I
Horse II

Devolve anything that mutates and await a pop-up about Kim Shardakian buying a new pugapoo. Now only evolve:

Dog I
Drug Resistance I
Gene Hardening I
Cold Resistance I

Wait for a high infection rate before evolving lethal systems, using your reshuffles if the cure gets too high. Devolve Horse I and wait for the pop-up indicating that you killed Kim Shardakian's dog for:

Call PETA

Make a celebrity cry

Call PETA
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Do Nipah again on casual with:

ATP Boost
Creationist
Aquacyte
Extremophile
Ionised Helix

Start anywhere and evolve:

Hendra Traits
Horse I and II
Dog I
Cold Resistance I and II
Heat Resistance I
Drug Resistance I
Genetic Hardening I and II

At this point, SAVE. Wait for the pop-up "Lude Jaw claims Nipah cure". If the popup doesn't appear before 100% infection, reload your save. Evolve:

Encephalitic Shift
Headache
Nuchal Rigidity
Fever
Photophobia
Blurred Vision
Hallucinations
Drowsiness
Confusion
Memory Loss

SAVE again and wait for the pop-up saying "Lude Jaw triggers infection in (country name)" for:

Who needs Science

Show the world how useful homeopathy is

Who needs Science
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start up another Nipah run on casual with:

ATP Boost
Aquacyte
Trans-Stasis
Creationist
Extremophile

Start anywhere and devolve anything that deviates from this path:

Bat II
Swine I and II
Nausea
Vomiting
Photophobia
Drowsiness
Dysphagia
Drug Resistance I and II
Cold Resistance I
Heat Resistance I
Headache
Nuchal Rigidity
Fever

Now, stop devolving and just wait for a pop-up about a film being announced about your plague. Evolve Confusion and Memory Loss as soon as you see this, and wait until another pop-up about the film failing for:

Contagion Cancelled

Prevent a film about your plague being made

Contagion Cancelled
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start over again on casual with Nipah with:

ATP Boost
Darwinist
Aquacyte
Hydrophile
Trans-Stasis

Start in India and evolve:

Bat II
Swine I
Nausea
Swine II
Bat III
Bat IV
Respiratory Shift
Vomiting

Pulmonary Edema

Hemoptysis
Hendra Traits
Cedar Traits
Fomites I and II
Water I and II
Drug Resistance I and II
Pulmonary Hemorrhage
Respiratory Failure
Air I and II
Cold Resistance I and II
Heat Resistance I and II
Environmental Hardening
Encaphalitic Shift

Keep the cure low and introduce some more lethality until completion. This will get you:

Complete Nipah Virus

Score 3 biohazards with Nipah Virus scenario

Complete Nipah Virus
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Frozen Virus is next, which contains another miscellaneous achievement. Start off on casual with:

ATP Boost
Darwinist
Aquacyte
Extrempohile
Patho-Stasis

Evolve:

DNA Repair I
Edentulism
Amoeba II
Livestock I
Bird I
Insect I
Amoeba III
Livestock II
Bird II
Insect II
DNA Repair II, III, IV, V

Full DNA repair
Drug resistance I and II
Heat resistance I, II, III
Carnivorous Denticulation
Bone Dysplasia
Cranial Elephantitis
Neanderthal Regression

After that last symptom, you'll unlock:

Who needs brains

Take humanity back to the stone age

Who needs brains
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Complete Frozen Virus

Score 3 biohazards with Frozen Virus scenario

Complete Frozen Virus
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now, it's Artificial Organs. There is another achievement tied to this as well, so pick Prion on casual with:

Metabolic Hijack
Genetic Mimic
Native Biome
Extremophile
Sympto-Statis

Start in India and evolve:

Air/Water I
Nausea
Coughing
Rash
Insomnia
Cysts
Anemia
Vomiting
Sweating
Hyper Sensitivity
Abscesses
Inflammation
Diarrhea
Skin Lesions
Tumors
Internal Hemorrhaging

Now when the pop up "Artifical Organs to Save Lives" comes on screen, SAVE.

Paranoia
Cold Resistance I
Drug Resistance I
Cold Resistance II
Neutral Atrophy I, II, III
Genetic Hardening I and II

Wait for the pop-up about people ripping out their organs and:

I never asked for this

Feel the negative side of artificial organs

I never asked for this
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start up another AO run, choosing Bacteria on casual with:

ATP Boost
Genetic Mimic
Teracyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Coughing

Rash
Sneezing
Sweating
Skin Lesions
Water/Air I and II
Extreme Bio Aerosol
Drug/Cold/Heat Resistance I and II
Environmental Hardening
Necrosis
Insomnia
Paranoia
Seizures
Insanity
Cysts
Hyper Sensitivity
Paralysis
Coma

Wait for everyone to be infected before evolving:

Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging
Systemic Infection

This will earn you:

Complete Artificial Organs

Score 3 biohazards with Artificial Organs scenario

Complete Artificial Organs
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Santa's Little Helper is next, this one is easy as you are automatically given the Neurax Worm. Use any genes with ATP Boost and start anywhere before evolving:

Festive Tendrils
Sloth
Gluttony
Jealousy
Indulgence
Partying
Intoxication

This combo grants you:

On The Naughty List

Put humanity on Santa's naughty list

On The Naughty List
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Now, unlock all of the plane abilities on both sides, the final three are Red Nose Guide, Red Suited Pilot and Digital Elf. This gets you:

Ultimate Christmas

Discover the Ultimate Christmas Combo

Ultimate Christmas
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start up another Santa's Little Helper scenario on casual with:

ATP Boost
Genetic Mimic
Aerocyte
Hydrophile
Trans-Stasis

Start your plague in Saudi Arabia and evolve:

Cracker Cocoon
Emotive Radar
Santa's Little Neurax Worm
Festive Tendrils
Digital Elf
Digital Herald
Digital Angel
Solar Perfume I and II
Eggs-Nog
Sunny Side Up
Snowballs I and II
Fair-Weather Friend
Glow Worms
Snow Worm
Wellington Worm
Wild Side
Stocking Filler
Radio Worm
Gold Digger
Memory Lane
Laughter
Excitement
Joy
Indulgence
Partying

This will grant you:

Complete Santa's Little Helper

Score 3 biohazards in the Santa's Little Helper scenario

Complete Santa's Little Helper
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Last one, finally, is Teleportation. Start on casual with bacteria and:

ATP Boost
Aerocyte
Trans-Stasis
Genetic Mimic
Extremophile

Start in Saudi Arabia and evolve:

Air 1 & 2
Drug Resistance 1
Bacterial Resilience 1, 2, & 3
Drug Resistance 2
Water 1 & 2
Cold Resistance 1 & 2
Extreme Bioaerosol

At some point, maybe while saving DNA to evolve these, or afterwards.. you'll get a pop up saying people are rushing to buy teleportation tickets to safe countries. After a little while longer, whichever safe country they teleported to should become infected and you'll get another pop-up saying 'Portal attempt in *country* failure' for:

GLaDOS Says Hi

Make a teleport attempt end in tragedy

GLaDOS Says Hi
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Fire it up with Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Reshuffle your way to victory for:

Complete Teleportation

Score 3 biohazards in the Teleportation scenario

Complete Teleportation
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Yeah that kinda took an eternity. Luckily, the last thing we need to focus on consists of doing the 3 hardest scenarios repeatedly. Joy oh joy.

....or maybe not. The Royal Update that came out in January 2019 added a number of new scenarios, one of which I personally found to be the hardest to get a good score on. Start with Where is Everyone? on casual as Neurax Worm with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II
Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Then use reshuffles until transcendence is achieved, you should get 3 biohazards easily for:

Complete Where is Everyone?

Score 3 biohazards in the Where is Everyone? scenario

Complete Where is Everyone?
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Flight Club is up next, a really easy scenario made even easier by Trojan Planes. Load it up on Neurax Worm casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II
Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

End with reshuffles once again, wrap up this scenario and earn:

Complete Flight Club

Score 3 biohazards in the Flight Club scenario

Complete Flight Club
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Mad Cow Disease is next, and is honestly really tough due to its inconsistency. You need a score of 65,000 and you'll often find yourself scoring between 60-64K. Speed is the key, so if your islands aren't infected with all people sick by 10 months it's probably a good idea to restart. You'll be forced to use Prion, start on casual with:

ATP Boost
Genetic Mimic
Native Biome
Extremophile
Sympto-Stasis

Start in Saudi Arabia and evolve the following as soon as you get the points:

Heat Resistance 1
Hermetic Resilience
Frozen Resilience
Preservative Storage Resilience

Human Cross-Infection
Coughing
Pulmonary Edema
Coma
Cold Resistance 1
Mania
Delirium
Insanity
Cannibalism
Systemic Infection
Necrosis
Total Organ Failure
Ataxia
Blindness
Paralysis
Acute Encephalitis
Cold Resistance 2
Genetic Hardening 1
Pork
Fish

After infecting the fish you have a good chance of creating a "sushi crisis" once Japan is infected. Once you do you'll unlock:

Sushi Crisis

Start a Sushi Crisis in Japan

Sushi Crisis
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.


Abscesses
Pneumonia
Hallucinations
Seizures
Inflammation
Genetic Hardening 2
Plant Dissemination
Potato
Avocado

Now use reshuffles, you'll want to make sure you keep the cure rate lower than 15% and finish before the 400 day mark. If you score over 65K you will unlock:

Complete Mad Cow Disease

Score 3 biohazards in the Mad Cow Disease scenario

Complete Mad Cow Disease
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Last up we have Science Denial, which unfortunately doesn't allow the Neurax Worm. Choose Bacteria on Casual instead, using:

ATP Boost
Genetic Mimic
Teracyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Coughing

Rash
Sneezing
Sweating
Skin Lesions
Water/Air I and II
Extreme Bio Aerosol
Drug/Cold/Heat Resistance I and II
Environmental Hardening
Necrosis
Insomnia
Paranoia
Seizures
Insanity
Cysts
Hyper Sensitivity
Paralysis
Coma

Wait for everyone to be infected, and make a SAVE once there's a high rate. Continue on and evolve:

Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging
Systemic Infection

This will easily complete the scenario and unlock:

Complete Science Denial

Score 3 biohazards in the Science Denial scenario

Complete Science Denial
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now load your save and wait for the cure, devolve Coma and any Genetic Hardening symptoms. Once the cure reaches 100% a group of protesters will destroy it and you'll get:

The Cure Is A Lie

Inspire an anti-cure protest

The Cure Is A Lie
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The last new scenario is Ultimate Board Games, which is wildly different from anything else you've played before. In this instance you're creating a board game of some kind and infecting people with "hype", and "killing" them once they purchase the game. It doesn't seem feasible to sell a copy to everyone in the world since you have a 2 year deadline, but you normally succeed once you sell 20 million copies. You don't choose any abilities or pathogen types to begin with so just begin playing on casual.

We'll be starting off going for an easy victory with 3 biohazards, so start off first in the United States and look at the game design options you have. Under themes, select

Educational
Murder/Mystery
Horror
Strategy

Mechanics:

Co-operate Play
Player Elimination
Area Control
Press Your Luck

Components:

Dice
Miniatures
Tokens

Player Number:

2 Players
4+ Players

Start production of the game at this point, then evolve the following:

Videogame IP
Launch Kickstarter
Community Feedback
Film/TV Show IP
Advertise Online
Toy Line IP
Manufacture in United States
Community Outreach
Official Website
Begin Manufacturing
Begin to Sell Your Game

This opens up the "Distribution" tab, now you can evolve:

Launch Companion App
Direct Sales
Sell on Amazon
Sell on eBay
Local Game Stores
Super Fan Sendout 1
Durable Packaging 1

Now just wait out the remaining time. If your deadline hits with over 200 million sales and there still being interest, you'll win the scenario and likely get 3 biohazards for:

Complete Ultimate Board Games

Score 3 biohazards in the Ultimate Board Games scenario

Complete Ultimate Board Games
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The remaining achievements are related to board game combos, which are very easy and quick since they're guaranteed. All you have to do is select certain designs, begin production, and immediately get a pop-up stating what combo you produced. Your starting country doesn't matter, so pick anything and select:

Themes:

Adult
Economic

Mechanics:

Bluffing
Competitive Play
Hand Management
Player Elimination
Press Your Luck

Components:

Cards

Player Numbers:

Two Players
Three Players
Four+ Players

Begin production, get your combo, unlock:

Kind Of A Big Deal

Discover the Poker board game combo

Kind Of A Big Deal
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Animals
Sports

Mechanics:

Co-operative Play
Dice Rolling
Press Your Luck

Components:

Dice
Miniatures
Timers

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

A Colt Classic

Discover the Steeplechase board game combo

A Colt Classic
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Educational
Family
Party

Mechanics:

Co-operative Play
Dice Rolling
Memory

Components:

Dice
Cards
Miniatures
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Anything But Trivial

Discover the Trivial Pursuit board game combo

Anything But Trivial
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Economic
Party

Mechanics:

Competitive Play
Dice Rolling
Hand Management
Trading

Components:

Dice
Cards
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Plague-opoly

Discover the Monopoly board game combo

Plague-opoly
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Nautical
Strategy
War Game

Mechanics:

Competitive Play
Bluffing
Memory
Player Elimination
Press Your Luck

Components:

Miniatures

Player Numbers:

Two Players

Start production, get your combo, unlock:

Sinking Feelings

Discover the Battleship board game combo

Sinking Feelings
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Educational
Family

Mechanics:

Competitive Play
Hand Management

Components:

Tokens

Player Numbers:

Four+ Players

Start production, get your combo, unlock:

Spelling Out Success

Discover the Scrabble board game combo

Spelling Out Success
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Economic
Family
Humor
Party

Mechanics:

Co-operative Play
Dice Rolling
Press Your Luck
Hand Management

Components:

Dice
Cards
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Party Hard

Discover a compulsory enjoyment board game combo

Party Hard
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Strategy
War Games

Mechanics:

Competitive Play
Dice Rolling
Press Your Luck
Player Elimination
Area Control

Components:

Dice
Miniatures
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Catan You Believe It?

Discover the Settlers Of Catan board game combo

Catan You Believe It?
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Strategy
War Games

Mechanics:

Co-operative Play
Dice Rolling
Area Control
Player Elimination

Components:

Dice
Miniatures

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Taking Risks

Discover the Risk board game combo

Taking Risks
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Animals
Murder/Mystery
Nautical

Mechanics:

Co-operative Play
Area Control
Memory

Components:

Cards
Miniatures

Player Numbers:

Single Player

Start production, get your combo, unlock:

Killer Combo

Discover the Cluedo/Clue board game combo

Killer Combo
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Adult
War Game
Family

Mechanics:

Co-operative Play
Trading

Components:

Timers

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Awkward!

Discover an inappropriate board game combo

Awkward!
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Educational
Medical
Strategy

Mechanics:

Co-operative Play
Dice Rolling
Hand Management
Area Control

Components:

Dice
Cards
Tokens

Player Numbers:

Single Player
Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Infecting Tabletops

Discover a very familiar board game combo

Infecting Tabletops
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Animals
Horror

Mechanics:

Player Elimination
Dice Rolling
Press Your Luck

Components:

Dice
Cards
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Welcome To The Jungle!

Discover a cursed board game combo

Welcome To The Jungle!
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Alright with all that said and done...NOW you can do the 3 worst scenarios repeatedly.

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