Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Completed the game on HARD difficulty.
Fully upgraded Heller.
Acquired all 46 upgrades through Consumes.
Heller Consumed Mercer.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Destroyed 5 helicopters using Pack Leader.
Completed all //BLACKNET dossiers.
Mounted a helicopter using Whipfist.
Destroyed a Strike Team in 15 seconds or less.
Stealth hijacked 5 tanks or APCs.
Acquired 30 upgrades through Consumes.
Destroyed all Lairs.
20 or more kills with a single Hammerfist dive attack.
Found all BlackBoxes.
Spent at least 25 consecutive seconds in the air.
10 or more kills using a single Bio-Bomb.
Defeated all Field Ops teams.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Reached the highest point in the world.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
Consumed 10 //BLACKNET targets.
Acquired a Mutation in each of the 5 categories.
Destroyed 5 vehicles using a Finisher.
Acquired 10 upgrades through Consumes.
Destroyed a single Lair.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Weaponized 10 vehicles.
Countered enemy attacks 20 times using Shield.
Stealth Consumed 50 Blackwatch troopers.
Simultaneously killed 2 Brawlers using a single Devastator.
Deflected 5 missiles at enemies using Shield Block.
10 or more kills with a single Black Hole attack.
Triggered 50 alerts.
Karate kicked a helicopter.
Acquired 5 Mutations.
5 consumes in 10 seconds or less.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
Completed a //BLACKNET mission.
Dismembered a Brawler.
First Prototype Power aquired.
Heller met Father Guerra.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
Completed MEET YOUR MAKER, Mercer infected Heller.