Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Fully upgraded Heller.
Acquired all 46 upgrades through Consumes.
Completed the game on HARD difficulty.
Heller Consumed Mercer.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Completed all //BLACKNET dossiers.
Mounted a helicopter using Whipfist.
Acquired 30 upgrades through Consumes.
Defeated all Field Ops teams.
Found all BlackBoxes.
Destroyed all Lairs.
Spent at least 25 consecutive seconds in the air.
Destroyed 5 helicopters using Pack Leader.
Destroyed 5 vehicles using a Finisher.
Reached the highest point in the world.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
10 or more kills with a single Black Hole attack.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Simultaneously killed 2 Brawlers using a single Devastator.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Consumed 10 //BLACKNET targets.
Stealth hijacked 5 tanks or APCs.
Destroyed a Strike Team in 15 seconds or less.
Acquired a Mutation in each of the 5 categories.
Destroyed a single Lair.
Acquired 10 upgrades through Consumes.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Weaponized 10 vehicles.
5 consumes in 10 seconds or less.
Countered enemy attacks 20 times using Shield.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
Triggered 50 alerts.
Deflected 5 missiles at enemies using Shield Block.
Stealth Consumed 50 Blackwatch troopers.
Completed a //BLACKNET mission.
Dismembered a Brawler.
First Prototype Power aquired.
Acquired 5 Mutations.
Karate kicked a helicopter.
Heller met Father Guerra.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
Completed MEET YOUR MAKER, Mercer infected Heller.