Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've completed Story Mode on hard difficulty.
You've killed 53,596 infected.
You've completed all Consume Events.
You've achieved a Platinum Medal for all Events.
You've caught an object tossed by a Hydra; and have thrown it back.
You've shot down 50 helicopters while driving armor.
You've achieved a rating of Gold or better in all Events.
You've destroyed 2,000 vehicles.
You've collected all Landmark collectibles scattered across New York City.
You've acquired all nodes in the Web of Intrigue.
You've discovered the truth behind Hope, Idaho.
You've discovered the history of Elizabeth Greene.
You've discovered what happened to Alex Mercer.
You've acquired all upgrades available.
You've collected all Hint Collectibles scattered across New York City.
You've killed 15 characters with a single Whipfist attack.
You've run over 500 characters in a single tank.
You've consumed 50 Web Targets.
You've infiltrated 10 Military Bases disguised as a Commander.
You've destroyed 25 Infected Water Towers before they hatched.
You've evaded 10 strike teams.
You've consumed 200 characters to regain health.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've seized 50 vehicles from enemy hands.
It's definitely not you. You've patsied 5 military personnel.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've completed the Supreme Hybrid Boss Battle.
You've killed 50 characters in 5 seconds.
You've completed the Mother Boss Battle.
You've completed 3 missions without causing a single Military Alert.
You've completed the Supreme Hunter Boss Battle.
You're now certified to drive and fly all vehicles.
You've completed a mission without causing a single Military Alert.
You've completed the Specialist Boss Fight.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.