Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've shot down 50 helicopters while driving armor.
You've seized 50 vehicles from enemy hands.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've destroyed 2,000 vehicles.
You've run over 500 characters in a single tank.
You've consumed 200 characters to regain health.
You've killed 50 characters in 5 seconds.
You've completed a mission without causing a single Military Alert.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.
Complete the Specialist Boss Fight.
Complete the Supreme Hunter Boss Battle.
Complete the Mother Boss Battle.
Complete the Supreme Hybrid Boss Battle.
Complete Story Mode on hard difficulty.
Kill 53,596 infected.
Destroy 25 Infected Water Towers before they hatch.
Complete all Consume Events.
Collect all Landmark collectibles scattered across New York City.
Collect all Hint Collectibles scattered across New York City.
Complete 3 missions without causing a single Military Alert.
Catch any object tossed by a Hydra; and throw it back.
Destroy 20 Helicopters in a single Helicopter flight.
Kill 15 characters with a single Whipfist attack.
Discover what happened to Alex Mercer through the Web of Intrigue.
Discover the history of Elizabeth Greene through the Web of Intrigue.
Acquire all nodes of the Web of Intrigue.
Patsy 5 military personnel.
Evade 10 strike teams.
Infiltrate 10 Military Bases disguised as a Commander.
Gain the ability to drive and fly all vehicles.
Acquire all available upgrades.
Destroy 10 Military Bases or Infected Hives in New York City.
Consume 50 Web Targets.
Achieve a rating of Gold or better in all Events.
Complete the game while consuming 10 Civilians or fewer.
Complete Story Mode in any difficulty without dying.
Achieve a Platinum Medal in all Events.