Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've completed 3 missions without causing a single Military Alert.
You've completed all Consume Events.
You've acquired all upgrades available.
You've acquired all nodes in the Web of Intrigue.
You've discovered what happened to Alex Mercer.
You've discovered the history of Elizabeth Greene.
You've killed 15 characters with a single Whipfist attack.
You've destroyed 2,000 vehicles.
You've run over 500 characters in a single tank.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed the Supreme Hybrid Boss Battle.
You've discovered the truth behind Hope, Idaho.
You've consumed 50 Web Targets.
You've completed the Mother Boss Battle.
You've seized 50 vehicles from enemy hands.
You've caught an object tossed by a Hydra; and have thrown it back.
You've completed a mission without causing a single Military Alert.
You've destroyed 25 Infected Water Towers before they hatched.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've evaded 10 strike teams.
You've completed the Supreme Hunter Boss Battle.
You've killed 50 characters in 5 seconds.
You've infiltrated 10 Military Bases disguised as a Commander.
It's definitely not you. You've patsied 5 military personnel.
You've consumed 200 characters to regain health.
You're now certified to drive and fly all vehicles.
You've completed the Specialist Boss Fight.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.
Complete Story Mode on hard difficulty.
Kill 53,596 infected.
Collect all Landmark collectibles scattered across New York City.
Collect all Hint Collectibles scattered across New York City.
Shoot down 50 helicopters while driving armor.
Achieve a rating of Gold or better in all Events.
Complete Story Mode in any difficulty without dying.
Achieve a Platinum Medal in all Events.