Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've completed the Specialist Boss Fight.
You've consumed 200 characters to regain health.
You've destroyed 25 Infected Water Towers before they hatched.
You've infiltrated 10 Military Bases disguised as a Commander.
You're now certified to drive and fly all vehicles.
You've consumed 50 Web Targets.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've killed 53,596 infected.
You've completed Story Mode on hard difficulty.
You've acquired all nodes in the Web of Intrigue.
You've completed 3 missions without causing a single Military Alert.
You've collected all Landmark collectibles scattered across New York City.
You've collected all Hint Collectibles scattered across New York City.
You've completed a mission without causing a single Military Alert.
You've achieved a Platinum Medal for all Events.
You've achieved a rating of Gold or better in all Events.
You've discovered what happened to Alex Mercer.
You've completed all Consume Events.
You've discovered the truth behind Hope, Idaho.
You've completed the Supreme Hybrid Boss Battle.
You've shot down 50 helicopters while driving armor.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've acquired all upgrades available.
You've completed the Mother Boss Battle.
You've caught an object tossed by a Hydra; and have thrown it back.
You've evaded 10 strike teams.
You've completed the Supreme Hunter Boss Battle.
You've seized 50 vehicles from enemy hands.
It's definitely not you. You've patsied 5 military personnel.
You've destroyed 2,000 vehicles.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've discovered the history of Elizabeth Greene.
You've killed 15 characters with a single Whipfist attack.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've killed 50 characters in 5 seconds.
You've run over 500 characters in a single tank.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.