Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've completed the Mother Boss Battle.
You've completed 3 missions without causing a single Military Alert.
You've caught an object tossed by a Hydra; and have thrown it back.
You've evaded 10 strike teams.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've completed Story Mode on hard difficulty.
You've achieved a Platinum Medal for all Events.
You've killed 53,596 infected.
You've achieved a rating of Gold or better in all Events.
You've collected all Landmark collectibles scattered across New York City.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've collected all Hint Collectibles scattered across New York City.
You've acquired all nodes in the Web of Intrigue.
You've discovered what happened to Alex Mercer.
You've discovered the truth behind Hope, Idaho.
You've acquired all upgrades available.
You've completed all Consume Events.
You've completed the Supreme Hybrid Boss Battle.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've seized 50 vehicles from enemy hands.
You've completed the Supreme Hunter Boss Battle.
You've discovered the history of Elizabeth Greene.
You've consumed 50 Web Targets.
You've destroyed 25 Infected Water Towers before they hatched.
You're now certified to drive and fly all vehicles.
You've completed a mission without causing a single Military Alert.
You've destroyed 2,000 vehicles.
It's definitely not you. You've patsied 5 military personnel.
You've shot down 50 helicopters while driving armor.
You've completed the Specialist Boss Fight.
You've killed 15 characters with a single Whipfist attack.
You've infiltrated 10 Military Bases disguised as a Commander.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've consumed 200 characters to regain health.
You've killed 50 characters in 5 seconds.
You've run over 500 characters in a single tank.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.