Full list of all 46 Resident Evil 4 achievements worth 1,180 gamerscore. It takes around 60-80 hours to unlock all of the achievements in the base game.
The base game contains 39 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 7 achievements worth 180 Gamerscore.
Complete the main story on Hardcore mode with an S+ rank.
Complete the main story on Standard mode with an S+ rank.
Obtain all treasures indicated on the castle treasure map in a single playthrough.
Reach the top of the clock tower without the lift stopping once.
Obtain all treasures indicated on the village treasure map in a single playthrough.
Complete the main story without talking to the Merchant once.
Complete the main story using only knives and handguns. (Excluding specific battles.)
Complete the main story without using a recovery item.
Make it through both minecart sections in the underground tunnel without taking any damage.
Defeat a Garrador using only knives.
Obtain all weapons.
Escape on the water scooter without taking any damage.
Complete the main story on Professional mode.
Complete the main story on Hardcore mode or higher.
Complete the main story within 8 hours.
Throw a grenade into Ramón Salazar's mouth.
Destroy all Clockwork Castellans.
Complete the main story on Standard mode or higher.
Defeat Osmund Saddler.
Obtain all treasures indicated on the island treasure map in a single playthrough.
Complete all requests from the Merchant.
Defeat Jack Krauser.
Earn an S rank in all games at the shooting range.
Destroy 5 targets at the shooting range with one shot.
Kill 2 parasites inside a Regenerador with a single bullet.
Defeat Ramón Salazar.
Defeat 3 enemies at once with a flash grenade.
Get the exclusive upgrade for a weapon.
Defeat the Verdugo.
Sell a single treasure for at least 100000 ptas.
Use a cannon to defeat a zealot.
Defeat Bitores Méndez.
Rescue Ashley as she's being carried away by the enemy.
Defeat Del Lago.
Complete a game at the shooting range.
Destroy a Clockwork Castellan.
Upgrade a weapon.
Complete a request for the Merchant.
Parry an enemy with a knife.
Complete Separate Ways on Professional mode with an S+ rank.
Complete Separate Ways on Professional mode.
Complete Separate Ways on Hardcore mode or higher.
Complete Separate Ways on Standard mode or higher.
Defeat Osmund Saddler in Separate Ways.
Defeat Pesanta in Separate Ways.
Defeat El Gigante in Separate Ways.