Full list of all 46 Resident Evil 4 achievements worth 1,180 gamerscore. It takes around 60-80 hours to unlock all of the achievements in the base game.
The base game contains 39 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 7 achievements worth 180 Gamerscore.
Complete the main story on Standard mode with an S+ rank.
Complete the main story using only knives and handguns. (Excluding specific battles.)
Destroy 5 targets at the shooting range with one shot.
Obtain all weapons.
Destroy all Clockwork Castellans.
Escape on the water scooter without taking any damage.
Kill 2 parasites inside a Regenerador with a single bullet.
Obtain all treasures indicated on the castle treasure map in a single playthrough.
Complete the main story on Hardcore mode with an S+ rank.
Complete the main story on Professional mode.
Complete the main story on Hardcore mode or higher.
Complete the main story on Standard mode or higher.
Reach the top of the clock tower without the lift stopping once.
Obtain all treasures indicated on the village treasure map in a single playthrough.
Complete the main story without talking to the Merchant once.
Complete the main story without using a recovery item.
Complete the main story within 8 hours.
Obtain all treasures indicated on the island treasure map in a single playthrough.
Defeat Osmund Saddler.
Defeat Jack Krauser.
Defeat Ramón Salazar.
Throw a grenade into Ramón Salazar's mouth.
Make it through both minecart sections in the underground tunnel without taking any damage.
Defeat the Verdugo.
Defeat 3 enemies at once with a flash grenade.
Sell a single treasure for at least 100000 ptas.
Get the exclusive upgrade for a weapon.
Defeat a Garrador using only knives.
Use a cannon to defeat a zealot.
Defeat Bitores Méndez.
Rescue Ashley as she's being carried away by the enemy.
Defeat Del Lago.
Complete a game at the shooting range.
Upgrade a weapon.
Complete a request for the Merchant.
Parry an enemy with a knife.
Destroy a Clockwork Castellan.
Complete all requests from the Merchant.
Earn an S rank in all games at the shooting range.
Complete Separate Ways on Professional mode.
Complete Separate Ways on Hardcore mode or higher.
Complete Separate Ways on Standard mode or higher.
Defeat El Gigante in Separate Ways.
Defeat Osmund Saddler in Separate Ways.
Defeat Pesanta in Separate Ways.
Complete Separate Ways on Professional mode with an S+ rank.