Full list of all 46 Resident Evil 4 achievements worth 1,180 gamerscore. It takes around 60-80 hours to unlock all of the achievements in the base game.
The base game contains 39 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 7 achievements worth 180 Gamerscore.
Complete the main story without talking to the Merchant once.
Complete the main story without using a recovery item.
Throw a grenade into Ramón Salazar's mouth.
Reach the top of the clock tower without the lift stopping once.
Complete the main story on Hardcore mode or higher.
Destroy all Clockwork Castellans.
Obtain all treasures indicated on the island treasure map in a single playthrough.
Obtain all treasures indicated on the castle treasure map in a single playthrough.
Complete all requests from the Merchant.
Defeat the Verdugo.
Obtain all treasures indicated on the village treasure map in a single playthrough.
Complete the main story within 8 hours.
Escape on the water scooter without taking any damage.
Make it through both minecart sections in the underground tunnel without taking any damage.
Complete the main story on Standard mode or higher.
Defeat Osmund Saddler.
Defeat Jack Krauser.
Defeat Ramón Salazar.
Sell a single treasure for at least 100000 ptas.
Get the exclusive upgrade for a weapon.
Defeat 3 enemies at once with a flash grenade.
Use a cannon to defeat a zealot.
Defeat Bitores Méndez.
Rescue Ashley as she's being carried away by the enemy.
Defeat Del Lago.
Complete a game at the shooting range.
Destroy a Clockwork Castellan.
Upgrade a weapon.
Complete a request for the Merchant.
Parry an enemy with a knife.
Defeat a Garrador using only knives.
Kill 2 parasites inside a Regenerador with a single bullet.
Obtain all weapons.
Complete the main story on Standard mode with an S+ rank.
Complete the main story on Hardcore mode with an S+ rank.
Complete the main story on Professional mode.
Complete the main story using only knives and handguns. (Excluding specific battles.)
Earn an S rank in all games at the shooting range.
Shoot through and destroy 5 targets at the shooting range with a single shot.
Defeat El Gigante in Separate Ways.
Defeat Pesanta in Separate Ways.
Defeat Osmund Saddler in Separate Ways.
Complete Separate Ways on Standard mode or higher.
Complete Separate Ways on Hardcore mode or higher.
Complete Separate Ways on Professional mode.
Complete Separate Ways on Professional mode with an S+ rank.