Full list of all 46 Resident Evil 4 achievements worth 1,180 gamerscore. It takes around 60-80 hours to unlock all of the achievements in the base game.
The base game contains 39 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 7 achievements worth 180 Gamerscore.
Earn an S rank in all games at the shooting range.
Destroy 5 targets at the shooting range with one shot.
Complete the main story on Hardcore mode with an S+ rank.
Complete the main story on Standard mode with an S+ rank.
Complete the main story using only knives and handguns. (Excluding specific battles.)
Complete the main story without talking to the Merchant once.
Complete the main story without using a recovery item.
Obtain all weapons.
Destroy all Clockwork Castellans.
Complete all requests from the Merchant.
Obtain all treasures indicated on the island treasure map in a single playthrough.
Reach the top of the clock tower without the lift stopping once.
Obtain all treasures indicated on the castle treasure map in a single playthrough.
Defeat a Garrador using only knives.
Obtain all treasures indicated on the village treasure map in a single playthrough.
Complete the main story within 8 hours.
Throw a grenade into Ramón Salazar's mouth.
Defeat the Verdugo.
Complete the main story on Professional mode.
Complete the main story on Hardcore mode or higher.
Make it through both minecart sections in the underground tunnel without taking any damage.
Sell a single treasure for at least 100000 ptas.
Destroy a Clockwork Castellan.
Complete the main story on Standard mode or higher.
Escape on the water scooter without taking any damage.
Defeat Osmund Saddler.
Defeat Jack Krauser.
Kill 2 parasites inside a Regenerador with a single bullet.
Get the exclusive upgrade for a weapon.
Defeat Ramón Salazar.
Complete a game at the shooting range.
Use a cannon to defeat a zealot.
Defeat Bitores Méndez.
Parry an enemy with a knife.
Defeat 3 enemies at once with a flash grenade.
Rescue Ashley as she's being carried away by the enemy.
Defeat Del Lago.
Upgrade a weapon.
Complete a request for the Merchant.
Complete Separate Ways on Professional mode with an S+ rank.
Complete Separate Ways on Professional mode.
Complete Separate Ways on Hardcore mode or higher.
Complete Separate Ways on Standard mode or higher.
Defeat Osmund Saddler in Separate Ways.
Defeat Pesanta in Separate Ways.
Defeat El Gigante in Separate Ways.