Full list of all 60 Rocksmith achievements worth 1,250 gamerscore. It takes around 50-60 hours to unlock all of the achievements in the base game on Xbox 360.
The base game contains 50 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 10 achievements worth 250 Gamerscore.
Collect all guitars
Reach Rank 11
Reach Rank 10
Beat 1,000,000 points in the Guitarcade game: Dawn of the Chordead
Beat 2,000,000 points in the Guitarcade game: Big Swing Baseball
Play the Guitarcade game: Big Swing Baseball
Complete a Master Event
Play the Guitarcade game: Dawn of the Chordead
Beat 1,000,000 points in the Guitarcade game: Harmonically Challenged
Play the Guitarcade game: Harmonically Challenged
Earn all Gold Technique Medals
Earn all Bronze Technique Medals
Reach Rank 9
Beat 50,000,000 points in the Guitarcade game: Scale Runner
Beat 5,000,000 points in the Guitarcade game: Quick Pick Dash
Reach Rank 8
Collect 50 effects pedals
Play the Guitarcade game: Quick Pick Dash
Reach Rank 7
Reach Rank 6
Play the Guitarcade game: Scale Runner
Qualify for a Double Encore
Reach Rank 5
Beat 100,000 points in a Chord Arrangement
Beat a 25 Chord Streak
Beat 15,000,000 points in the Guitarcade game: Super Slider
Beat 100,000 points in a Single Note Arrangement
Play the Guitarcade game: Super Slider
Beat 150,000,000 points in the Guitarcade game: Super Ducks
Play the Guitarcade game: Super Ducks
Reach Rank 4
Beat 200,000 points in Master Mode
Reach Rank 3
Beat a 5 Chord Streak
Beat a 750 Note Streak
Beat a 500 Note Streak
Reach Rank 2
Qualify for an Encore
Play an Event
Beat 100,000 points in a Combo Arrangement
Beat 10,000,000 points in the Guitarcade game: Ducks
Play the Guitarcade game: Ducks
Use the Tuner to tune to Drop-D
Create and save a custom tone
Using a mic, sing along and achieve Nice Singing
Visit the shop
Use the Amp
Beat a 100 Note Streak
Play multiplayer with 2 guitars
Complete Soundcheck (Reach Rank 1)
Reach rank 11 on Bass
Collect all basses
Collect all bass gear
Complete all Bass Technique Challenges to Gold
Complete all Bass Technique Challenges to Bronze
Earn a bass pedal, amp, or cabinet
Complete a bass event
Beat 100,000 points in a Bass arrangement
Play a song with emulated bass using a guitar
Play a bass arrangement