Full list of all 60 Rocksmith achievements worth 1,250 gamerscore. It takes around 50-60 hours to unlock all of the achievements in the base game on Xbox 360.
The base game contains 50 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 10 achievements worth 250 Gamerscore.
Collect 50 effects pedals
Reach Rank 11
Beat 100,000 points in a Chord Arrangement
Reach Rank 10
Play multiplayer with 2 guitars
Complete a Master Event
Beat 150,000,000 points in the Guitarcade game: Super Ducks
Reach Rank 9
Beat 1,000,000 points in the Guitarcade game: Harmonically Challenged
Play the Guitarcade game: Harmonically Challenged
Reach Rank 8
Earn all Gold Technique Medals
Earn all Bronze Technique Medals
Reach Rank 7
Beat 100,000 points in a Single Note Arrangement
Reach Rank 6
Beat 5,000,000 points in the Guitarcade game: Quick Pick Dash
Play the Guitarcade game: Quick Pick Dash
Create and save a custom tone
Beat a 750 Note Streak
Beat 50,000,000 points in the Guitarcade game: Scale Runner
Beat 10,000,000 points in the Guitarcade game: Ducks
Beat 200,000 points in Master Mode
Beat a 500 Note Streak
Reach Rank 5
Beat 100,000 points in a Combo Arrangement
Play the Guitarcade game: Scale Runner
Reach Rank 4
Use the Tuner to tune to Drop-D
Play the Guitarcade game: Big Swing Baseball
Reach Rank 3
Play the Guitarcade game: Super Ducks
Visit the shop
Beat a 25 Chord Streak
Beat a 5 Chord Streak
Reach Rank 2
Beat a 100 Note Streak
Play the Guitarcade game: Dawn of the Chordead
Play the Guitarcade game: Super Slider
Qualify for a Double Encore
Qualify for an Encore
Play an Event
Use the Amp
Play the Guitarcade game: Ducks
Complete Soundcheck (Reach Rank 1)
Beat 2,000,000 points in the Guitarcade game: Big Swing Baseball
Beat 15,000,000 points in the Guitarcade game: Super Slider
Beat 1,000,000 points in the Guitarcade game: Dawn of the Chordead
Collect all guitars
Using a mic, sing along and achieve Nice Singing
Complete all Bass Technique Challenges to Gold
Complete all Bass Technique Challenges to Bronze
Earn a bass pedal, amp, or cabinet
Complete a bass event
Beat 100,000 points in a Bass arrangement
Play a song with emulated bass using a guitar
Play a bass arrangement
Collect all basses
Collect all bass gear
Reach rank 11 on Bass