Full list of all 46 Slay The Spire achievements worth 1,070 gamerscore. It takes around 150-200 hours to unlock all of the achievements in the base game.
The base game contains 44 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 2 achievements worth 70 Gamerscore.
Complete Ascension Level 20.
Obtain all other Achievements
Win a Daily Climb.
Finish Donu with a Feed.
Play 10 Shivs in a single turn.
Beat the game with a single relic.
Defeat a boss on turn 1.
Beat the game in under 20 minutes.
Have 10 or more buffs during combat.
Have 25 or more Focus during combat.
Play 25 cards in a single turn.
Channel 9 Plasma in a single turn.
Complete Ascension Level 10.
Beat the game with a 5 card deck or smaller.
Have 3 or fewer cards in hand, draw, and discard pile combined.
Beat the game with a deck containing no uncommons or rares.
Complete the Ending with the Ironclad, Silent, and Defect.
Complete the Ending with the Silent.
Complete the Ending with the Ironclad.
Have 999 Block during combat.
Defeat the Transient before it fades away.
Win a battle with 1 HP remaining.
Complete the Ending with the Defect.
Win a combat without playing an Attack.
Exhaust 20 cards in a single combat.
Apply 99 or more Poison on a single enemy.
Defeat a boss without taking any damage.
Have 50 or more Strength during combat.
Defeated the Awakened One.
Defeat 3 enemies with Poison in a single combat.
Defeated the Time Eater.
Beat the game with the Defect.
Have 99 or more Block during combat.
Beat the game with the Silent.
Have 9 Energy during a single turn of combat.
Defeated the Collector.
Unlock Ascension mode.
Beat the game with the Ironclad.
Defeated Donu & Deca.
Defeated the Bronze Automaton.
Defeated the Champ.
Defeated the Slime Boss.
Defeated Hexaghost.
Defeated the Guardian.
Complete the Ending with the Watcher
Beat the game with the Watcher