Full list of all 79 The Binding of Isaac: Rebirth achievements worth 1,520 gamerscore.
The base game contains 58 achievements worth 1,000 Gamerscore, and there are 3 DLC packs containing 21 achievements worth 520 Gamerscore.
Beat the Caves/Catacombs without taking damage.
Kill Satan with Lazarus.
Finish the game's final secret.
Kill Satan with Azazel.
Kill Isaac with Lazarus.
Beat the Dark Room with Isaac.
Kill Satan with Samson.
Kill Isaac with Samson.
Kill Isaac with Eve.
Kill Satan with ???.
Beat the Dark Room.
You are the best!
Kill Satan with Judas.
Beat the Boss Rush.
Beat the Caves 30 times.
Beat the Basement 40 times.
Beat the Chest or Dark Room without taking damage.
Beat the Chest.
Kill Isaac with Cain.
Kill Satan with Maggy.
Beat Sheol 5 times.
Kill Isaac with Maggy.
Beat Cathedral 5 times.
Kill Isaac with Eden.
Beat the Depths 20 times.
Kill Isaac with Isaac.
Beat the Womb/Utero without taking damage.
Kill Mom's Heart 11 times.
Kill Isaac with Azazel.
Kill Mom's Heart 10 times.
Kill Mom's Heart 9 times.
Kill Satan with Eve.
Kill Mom's Heart 8 times.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Kill Satan with Eden.
Kill Isaac with Judas.
Kill Satan with Cain.
Kill Mom's Heart 5 times.
Kill all 7 sins.
Beat 2 levels in a row without picking up any hearts.
Beat the Basement/Cellar without taking damage.
Kill Mom's Heart 3 times.
Make 3 deals with the devil in one run.
Beat 2 levels in a row without taking damage.
Kill Satan
Kill Satan with Isaac.
Kill Mom using the Bible.
Beat the Womb for the first time,
Kill Mom.
Hold 55 or more pennies at one time.
Have 7 or more max red hearts at one time.
Have 4 or more soul hearts at one time
Kill Isaac with The Lost.
Kill Satan with The Lost.
Beat the Depths/Necropolis without taking damage.
Beat all 20 Challenges.
Collect all items and unlock all secrets and endings.
100% the game!
Kill ??? with Lilith
Kill The Lamb with Lilith
Beat Greed Mode with Azazel
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
The other side is calling...
Beat everything in Hard Mode as every character.
...
RIP
Donate 500 coins to the Greed Machine
Beat Delirium
Kill Mega Satan
Kill The Lamb
Unlocked a new area
Just Stop!
Uncover some lost remains..