Full list of all 79 The Binding of Isaac: Rebirth achievements worth 1,520 gamerscore.
The base game contains 58 achievements worth 1,000 Gamerscore, and there are 3 DLC packs containing 21 achievements worth 520 Gamerscore.
Beat the Caves/Catacombs without taking damage.
Beat the Caves 30 times.
Beat the Depths 20 times.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Beat the Basement 40 times.
Beat the Boss Rush.
Kill Mom's Heart 11 times.
Kill Mom's Heart 10 times.
Kill Mom's Heart 9 times.
Kill Mom's Heart 8 times.
Kill Mom's Heart 5 times.
Kill Mom's Heart 3 times.
Kill Satan
Kill Satan with Azazel.
Beat 2 levels in a row without taking damage.
Beat the Basement/Cellar without taking damage.
Kill all 7 sins.
Make 3 deals with the devil in one run.
Kill Mom using the Bible.
Kill Mom.
Beat 2 levels in a row without picking up any hearts.
Beat the Womb for the first time,
Have 7 or more max red hearts at one time.
Hold 55 or more pennies at one time.
Have 4 or more soul hearts at one time
Finish the game's final secret.
Kill Isaac with Isaac.
Kill Satan with Isaac.
Kill Isaac with The Lost.
Kill Satan with The Lost.
Kill Isaac with Maggy.
Kill Satan with Maggy.
Kill Isaac with Cain.
Kill Satan with Cain.
Kill Isaac with Judas.
Kill Satan with Judas.
Kill Isaac with Eve.
Kill Satan with Eve.
Kill Isaac with Samson.
Kill Satan with Samson.
Kill Isaac with Azazel.
Kill Isaac with Lazarus.
Kill Satan with Lazarus.
Kill Isaac with Eden.
Kill Satan with Eden.
Beat the Depths/Necropolis without taking damage.
Beat the Womb/Utero without taking damage.
Beat the Chest or Dark Room without taking damage.
Beat all 20 Challenges.
Beat the Dark Room.
Beat the Chest.
Beat the Dark Room with Isaac.
Kill Satan with ???.
Beat Cathedral 5 times.
Beat Sheol 5 times.
You are the best!
Collect all items and unlock all secrets and endings.
100% the game!
Beat Greed Mode with Azazel
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
The other side is calling...
Beat everything in Hard Mode as every character.
...
RIP
Unlocked a new area
Beat Delirium
Just Stop!
Kill Mega Satan
Donate 500 coins to the Greed Machine
Kill The Lamb
Uncover some lost remains..