Full list of all 79 The Binding of Isaac: Rebirth achievements worth 1,520 gamerscore.
The base game contains 58 achievements worth 1,000 Gamerscore, and there are 3 DLC packs containing 21 achievements worth 520 Gamerscore.
Beat all 20 Challenges.
Beat the Boss Rush.
Beat the Dark Room.
Beat the Chest.
Collect all items and unlock all secrets and endings.
100% the game!
Kill Mom.
Kill Satan with The Lost.
Kill Isaac with The Lost.
Finish the game's final secret.
Kill Satan with Lazarus.
Kill Isaac with Samson.
Kill Satan with Samson.
Beat the Depths/Necropolis without taking damage.
Kill Satan with ???.
Kill Satan with Eve.
Kill Isaac with Lazarus.
Kill Satan with Eden.
Beat the Chest or Dark Room without taking damage.
Beat the Womb/Utero without taking damage.
Kill Isaac with Eden.
Beat the Dark Room with Isaac.
You are the best!
Kill Satan with Maggy.
Beat Sheol 5 times.
Kill Isaac with Cain.
Kill Isaac with Azazel.
Beat the Caves 30 times.
Kill Isaac with Maggy.
Beat Cathedral 5 times.
Beat the Basement 40 times.
Kill Isaac with Judas.
Beat the Caves/Catacombs without taking damage.
Kill Isaac with Isaac.
Kill Mom using the Bible.
Kill Isaac with Eve.
Kill Satan with Azazel.
Kill Mom's Heart 11 times.
Beat the Depths 20 times.
Kill Mom's Heart 10 times.
Kill Satan with Judas.
Kill Mom's Heart 9 times.
Beat 2 levels in a row without picking up any hearts.
Beat the Basement/Cellar without taking damage.
Kill Satan with Cain.
Kill Mom's Heart 8 times.
Kill all 7 sins.
Kill Mom's Heart 5 times.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Kill Mom's Heart 3 times.
Have 7 or more max red hearts at one time.
Kill Satan
Kill Satan with Isaac.
Beat 2 levels in a row without taking damage.
Beat the Womb for the first time,
Make 3 deals with the devil in one run.
Hold 55 or more pennies at one time.
Have 4 or more soul hearts at one time
Beat Greed Mode with Azazel
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
The other side is calling...
Beat everything in Hard Mode as every character.
...
RIP
Unlocked a new area
Beat Delirium
Just Stop!
Kill Mega Satan
Donate 500 coins to the Greed Machine
Kill The Lamb
Uncover some lost remains..