Full list of all 79 The Binding of Isaac: Rebirth achievements worth 1,520 gamerscore.
The base game contains 58 achievements worth 1,000 Gamerscore, and there are 3 DLC packs containing 21 achievements worth 520 Gamerscore.
Kill Satan with ???.
Kill Isaac with Maggy.
Kill Satan with The Lost.
Kill Mom using the Bible.
Kill Isaac with The Lost.
Beat the Depths/Necropolis without taking damage.
Finish the game's final secret.
Kill Isaac with Cain.
Beat the Boss Rush.
Beat the Dark Room.
Beat the Chest.
Beat the Caves/Catacombs without taking damage.
Kill Satan with Samson.
Kill Satan with Lazarus.
Kill Isaac with Judas.
Kill Satan with Eve.
Kill Mom.
Kill Satan with Cain.
Kill Isaac with Samson.
Kill Satan with Maggy.
Kill Isaac with Lazarus.
Kill Isaac with Eve.
Kill Isaac with Azazel.
Kill Satan with Eden.
Kill Isaac with Eden.
Beat the Chest or Dark Room without taking damage.
You are the best!
Beat Cathedral 5 times.
Beat the Dark Room with Isaac.
Beat Sheol 5 times.
Kill Isaac with Isaac.
Kill Mom's Heart 11 times.
Kill Satan with Azazel.
Kill Mom's Heart 10 times.
Beat the Caves 30 times.
Kill Satan with Judas.
Kill Mom's Heart 9 times.
Beat the Depths 20 times.
Kill Satan
Kill Satan with Isaac.
Kill Mom's Heart 8 times.
Kill Mom's Heart 5 times.
Have 7 or more max red hearts at one time.
Beat the Basement 40 times.
Beat the Womb/Utero without taking damage.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Kill Mom's Heart 3 times.
Hold 55 or more pennies at one time.
Kill all 7 sins.
Beat 2 levels in a row without picking up any hearts.
Beat the Womb for the first time,
Beat 2 levels in a row without taking damage.
Beat the Basement/Cellar without taking damage.
Make 3 deals with the devil in one run.
Have 4 or more soul hearts at one time
Beat all 20 Challenges.
Collect all items and unlock all secrets and endings.
100% the game!
Collect all items and unlock all secrets
Kill The Lamb with Lilith
Kill The Lamb with Keeper
Kill ??? with Lilith
Kill ??? with Keeper
Donate 1000 coins in Greed Mode
Beat Greed Mode with Azazel
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
You are just like your father...
The other side is calling...
Beat everything in Hard Mode as every character.
...
RIP
Uncover some lost remains..
Beat Delirium
Kill Mega Satan
Unlocked a new area
Donate 500 coins to the Greed Machine
Kill The Lamb
Just Stop!