Here is the full list of all 28 Vampyr achievements worth 1,000 gamerscore. It takes around 40-50 hours to unlock all of the achievements on Xbox One.
Embrace Clay during your first meet with him
Finish the game without killing any citizens (not unlockable in Story Mode)
Complete the game
Defeat the Disaster
Gather all collectibles
Turn all districts to hostile status
Turn a district to hostile status
Find all melee weapons
Find all off-hand weapons
Find all Range Weapon
Find the recollection of Paulus Aurelianus
Take care of Swansea's fate
Defeat McCullum
Save this poor plant with water
Take care of Aloysius's fate
Defeat Doris
Upgrade a weapon to level 5
Defeat Mary
Take care of Sean's fate
Defeat Fergal
Heal 10 citizens
Take care of Dorothy's fate
Eat 10 rats
Upgrade a weapon with a module
Upgrade a weapon
Let Clay live during your first meeting with him
Take a ride with Doctor Swansea
Go to the Shelter and rest…