| Name | Description | Gamerscore |
| Ascend 20 | Complete Ascension Level 20. | 75 |
| Common Sense | Beat the game with a deck containing no uncommons or rares. | 25 |
| Who Needs Relics? | Beat the game with a single relic. | 25 |
| Focused | Have 25 or more Focus during combat. | 25 |
| Neon | Channel 9 Plasma in a single turn. | 25 |
| Secret Achievement | Continue playing to unlock this achievement. | 50 |
| Minimalist | Beat the game with a 5 card deck or smaller. | 25 |
| Secret Achievement | Continue playing to unlock this achievement. | 50 |
| Secret Achievement | Continue playing to unlock this achievement. | 50 |
| Secret Achievement | Continue playing to unlock this achievement. | 50 |
| The Transient | Defeat the Transient before it fades away. | 25 |
| Speed Climber | Beat the game in under 20 minutes. | 25 |
| Ooh Donut! | Finish Donu with a Feed. | 25 |
| Ascend 10 | Complete Ascension Level 10. | 15 |
| You Are Nothing | Defeat a boss on turn 1. | 15 |
| Barricaded | Have 999 Block during combat. | 15 |
| Ninja | Play 10 Shivs in a single turn. | 15 |
| Infinity | Play 25 cards in a single turn. | 15 |
| Jaxxed | Have 50 or more Strength during combat. | 15 |
| My Lucky Day | Win a Daily Climb. | 15 |
| Purity | Have 3 or fewer cards in hand, draw, and discard pile combined. | 15 |
| Powerful | Have 10 or more buffs during combat. | 15 |
| Sapphire | Beat the game with the Defect. | 20 |
| Impervious | Have 99 or more Block during combat. | 15 |
| Catalyst | Apply 99 or more Poison on a single enemy. | 15 |
| Come At Me | Win a combat without playing an Attack. | 15 |
| Emerald | Beat the game with the Silent. | 20 |
| Secret Achievement | Continue playing to unlock this achievement. | 15 |
| Secret Achievement | Continue playing to unlock this achievement. | 15 |
| Secret Achievement | Continue playing to unlock this achievement. | 15 |
| Perfect | Defeat a boss without taking any damage. | 15 |
| Ruby | Beat the game with the Ironclad. | 20 |
| Ascend 0 | Unlock Ascension mode. | 10 |
| Adrenaline | Have 9 Energy during a single turn of combat. | 15 |
| The Pact | Exhaust 20 cards in a single combat. | 15 |
| Plague | Defeat 3 enemies with Poison in a single combat. | 10 |
| Shrug It Off | Win a battle with 1 HP remaining. | 15 |
| Secret Achievement | Continue playing to unlock this achievement. | 10 |
| Secret Achievement | Continue playing to unlock this achievement. | 10 |
| Secret Achievement | Continue playing to unlock this achievement. | 10 |
| Secret Achievement | Continue playing to unlock this achievement. | 10 |
| Secret Achievement | Continue playing to unlock this achievement. | 10 |
| Secret Achievement | Continue playing to unlock this achievement. | 10 |
| Secret Achievement | Continue playing to unlock this achievement. | 100 |
We fused card games and roguelikes together to make the best single player deckbuilder we could. Craft a unique deck, encounter bizarre creatures, discover relics of immense power, and Slay the Spire!
Slay The Spire is developed by MegaCrit and published by Humble Bundle.