Resident Evil 3 is a single-player remake of the 1999 survival horror game Resident Evil 3: Nemesis.
It's set in the infamous Raccoon City and features Jill Valentine, a member of the S.T.A.R.S. police force, and her efforts to expose the nefarious goings-on within the pharmaceutical company Umbrella. Disappearances have been reported across Raccoon City, and Jill and her team know it's got something to do with Umbrella and their biological weapon, the T-Virus. But Umbrella have Raccoon City in their power, and Jill can't get anyone to listen to her evidence. A "cannibal virus" soon begins to spread through the streets, and the game's survival/horror aspects are about Jill trying to escape the plague, the undead, and the bioweapon hunting her down.
Aside from being trained for the S.T.A.R.S. force, Jill is also talented at picking locks and dealing with explosives, so these skills will likely feature in the gameplay. It sounds as though she'll have more of a diverse skill set than Resident Evil 2's Leon, who also had police training, although not as specialist as that needed for the S.T.A.R.S. team. A Capcom blog post
mentions that there'll be a twist in the timeline, for those players unfamiliar with the original game. It also mentions that, like the Resident Evil 2 remake, Resident Evil 3 will be played from an over-the-shoulder camera perspective.
The blog also says that Jill will have another enemy to avoid as she makes her way through Raccoon City, as Umbrella have also sent out their Umbrella Biohazard Countermeasure Service (U.B.C.S.) — a private military organisation. This is on top of the increased difficulty introduced by her pursuer, Nemesis, who's apparently more intelligent than Resident Evil 2's Tyrant, and able to use weapons — including projectiles. In Resident Evil 2, you could keep Tyrant and his insanely-loud boots at bay if you ran fast enough. It sounds as though this will be harder to accomplish with Nemesis. Just like Resident Evil 2, players will need to monitor health, ammo, items, and inventory space. Resident Evil 2 nailed the inventory management feature, making sure players had to double and triple-check their decisions about what to take or leave, and making each new inventory space feel like a real win.