| Name | Description | Gamerscore |
| Doomsday | Complete Hell on Earth | 20 |
| Darn It, They Keep BREAKING | Perform 33 Unique Glory Kills in a single save slot | 33 |
| The Hunters Became the Hunted | Kill the Doom Hunters | 30 |
| Interplanetary Fracking | Blow a hole in Mars | 20 |
| Thumbs Down | Best the Gladiator in the coliseum | 25 |
| Reforged and Refueled | Acquire a new Crucible in Taras Nabad | 50 |
| Secret Achievement | Continue playing to unlock this achievement. | 30 |
| Secret Achievement | Continue playing to unlock this achievement. | 90 |
| The Once and Future Slayer | Complete the Campaign on any difficulty | 50 |
| Secret Achievement | Continue playing to unlock this achievement. | 15 |
| Secret Achievement | Continue playing to unlock this achievement. | 15 |
| Running Up the High Score | Complete Extra Life Mode with 10 Extra Lives in your Inventory | 50 |
| Crystal Craving | Upgrade Health, Armor, or Ammo | 20 |
| King of the Crystals | Fully upgrade Health, Armor, or Ammo in a single save slot | 30 |
| This One's my Favorite | Complete a Praetor Suit Perk category in a single save slot | 15 |
| They're ALL My Favorite | Purchase all Praetor Suit Perks in a single save slot | 100 |
| Homemaykr | Spend 8 Sentinel Batteries in the Fortress of Doom in a single save slot | 25 |
| Extra Extra Lives | Pick up 20 Extra Lives Total in a single save slot | 30 |
| Reforged the Genie Lamp | Complete the cheat code collection in a single save slot | 10 |
| Metal Head | Complete the album collection in a single save slot | 10 |
| Playset Sold Separately | Complete the toy collection in a single save slot | 10 |
| If Only I Could Read… | Collect all physical Codex pages in a single save slot | 30 |
| Bonus Stage | Complete a Slayer Gate | 20 |
| Breaker of Gates | Complete all Slayer Gates in a single save slot | 40 |
| Gunpletionist | Master all Weapon Mods in a single save slot | 30 |
| Secret Achievement | Continue playing to unlock this achievement. | 20 |
| Mix and Match | Play as 5 different Player Demons in BATTLEMODE | 20 |
| Fight Like Hell | Do 5000 damage as a Player Demon in BATTLEMODE | 20 |
| Blood Bath | Kill 200 opponents in BATTLEMODE | 20 |
| Man vs Monsters | Play 25 BATTLEMODE matches | 25 |
| Weapons Expert | Kill a Player Demon with each of the 8 Slayer weapons in BATTLEMODE | 10 |
| Truce between Demons | Heal yourself or your teammate for 50000 health in BATTLEMODE | 20 |
| It's a Magic Number | Kill 666 Demons. | 67 |