For the Saving Throw rune, it was the last one I needed.
I suggest starting the first mission (The UAC) and if you got the rune active then there will be a little sand like clock by your health if it is not there then you have to die to reset it.
Stand in the fire on the cliff til your health is about 50 then enter the first area where enemy's spawn and let them hit you until your health is about 1-4.
When your screen turns blue and its in slow mo that's when you need to kill enemies.
Try not to get health as it will end it. Die to reset it and repeat.
Hope that helps.