Before going for this achievement, I went to Customize
from the main menu and adjusted all offensive players to 99 in each category to give my team the best possible advantage.
2 Controller Method
Main Profile (Offense) - Running Plays: Blast
Secondary Profile (Defense) - 3-4 Base: Amiens
The QB should hand the ball off to the RB, and there should be a significant gap in players directly in front of you. Running through the opening, you should be able to generate approximately 8-15 yards per carry. Use A to sprint faster. You can pause the game to see your progress.
You must also get 50 yards in a quarter for another achievement: