Prologue on Human difficulty.
I found the best Devil Breaker to be the Punch Line, so bring a few of those.
While facing Urizen press B to fire it at the crystal, it will hit it several times allowing you to focus on dodging. Whenever you get a chance shoot it with charged gun shots. After the crystal is destroyed, run up and attack Urizen. I would suggest saving your Devil trigger for this. He will eventually blow you back, and bring back the crystal. His attacks will become more aggressive... double laser beams, fireballs curve towards you. Continue with the punch line/charged shot combo to destroy the second crystal, then run up and finish urizen.