It appears that interceptions have been turned down heavily this year. I spent an entire half playing my usual method of a second controller throwing lob passes and pulling the receiver away, and the defense dropped every single ball whether I went for user catches or let the CPU handle it. But this works.
Go to settings. Under player skill turn interceptions and reaction time up to 100. Turn pass rushing down to 0. This will make it harder to get a sack and take away a chance at an interception.
Under CPU skill, turn pass blocking up to 100. Turn QB accuracy to 33 and WR catching to 0.
Edit your starting CBs, FS and SS to 99 speed, acceleration, awareness, catching, jumping, play recognition, zone coverage, man coverage, spectacular catch and catch in traffic.
Now play a game on rookie and punt the ball away whenever you get it. It's probably overkill, I got 6 interceptions while also going for KR and PR touchdowns and still had to kill clock at the end. But it's a guaranteed winner.