17 Jan 2010 18 Jan 2010
If you want to solo this achievement I recommend you equip yourself with some ammo and health regeneration mods. I played through this with a level 37 Hunter carrying the Sniper, Gunslinger and Survivor mods. Every class has at least one mod that will regenerate some type of ammo and health.
You can switch between mods quickly as needed depending on circumstances. Since you're playing solo, bringing up your inventory will pause the action so switching mods does not have to be a frantic task.
The health regen is important for the Vampire waves where you lose health over time. My Survivor health regen balanced the Vampire health drain so I didn't have to rush around looking for kills.
By bringing the right mods to Underdome you aren't so dependent on the ammo and health drops between waves. I didn't need to pick up a single drop.
If you don't have the mods you want, you can easily farm for them by starting the game at the Underdome, and do a quick check at the Medical vending machine, You can exit, check and re-enter very quickly. I got the mods I needed in about 20 minutes but remember it's random.
Another consideration is adjusting your skill tree for this type of play. Being spec'd for looting is no help in the Underdome so spend a little money to optimize for health, ammo and damage.
Hope this helps. :)