Plague Inc: Evolved

Welcome to the TrueAchievements walkthrough for Plague Inc. Evolved. I'm your host, Vitiated1, and along with some help from ManicMetalhead, we'll be guiding you through this game.


Plague Inc. is a strategy and simulation game, where you unleash a deadly pathogen on the world and must use your wits and tactics to evolve it in order to exterminate all life on earth. If you're someone like me, that's the coolest thing ever. Plague Inc. has tons of achievements in it, but with a hell of a lot of luck and patience, you can get them all.


The game has no multiplayer on the Xbox One, meaning no online achievements. Depending on luck, it may take around 100 or so hours to complete.

Save! The game occasionally installs with a bug that causes the inability to save or load games. If this happens to you, try to keep your saves to a maximum of 2 files. Save on a new slot, delete the one giving you issues, and run entirely with the new file. Having saves at crucial parts of the games ensure that you can just retry without going through the process all over again.

Evolve! In most instances, sitting on your evolution points is useless. Use them when you get them, to evolve transmission in the early stages before stockpiling them for a massive kill off once everyone is infected. It's the main strategy for winning the game.

Adapt! Sometimes things go astray. The cure may be developed incredibly fast, or countries may be taking ages to get infected. Change your strategy up a bit and always have a backup plan.

Slow down! I never played on the max speed, I usually had the middle speed on (speed is adjusted by the D-pad). This ensures things aren't slowly and horrifically boring, and not too fast so that things get missed. If you need a moment to pop bubbles, pause the timer completely and focus on them.

Pop! Whenever there are bubbles on the screen, pop them. They'll get you DNA points or slow the cure, so it's always beneficial to pop your bubbles.

Check the news! cn_up pulls up the news ticker, which is vital for most achievements related to "pop-ups". Check it frequently to find what you need.

I have to give credit to where it is due, so I'd like give thanks to Yo, It's Spicy!, the Steam community, and the members of TA who took the time to write up strategies and solutions for many of these achievements. I couldn't have done this game or guide without content from each of these places. Most of what you see contained in this guide is a conglomeration of their work, with the order pieced together by myself.

Keep in mind that a LOT of this game focuses on RNG (Random Number Generation) in order for certain events to occur. That's why I recommend saving at certain parts, so you can keep reloading the save until the RNG Gods bless you with what you need. If you don't see a pop-up for a certain combo or event when I mention it, don't despair. There are a great many opportunities to unlock a lot of these achievements. Be sure to check the news ticker (cn_up) to be certain that a pop-up hasn't occurred.

When I tell you to evolve X or Y, those are always found in the evolution menu under symptoms, transmissions, or abilities. Symptoms are things your disease does to people, whether it be coughing and sneezing or total organ failure. Transmissions are vectors, ways your disease spreads. Those would be things such as Insect, Water, Rodent, Air, etc. Abilities are things that make your disease tougher and more adaptable, such as Cold, Heat, and Drug Resistance. After unlocking one of those, another tier may be available to purchase (II, III, etc).

When the game starts, the only disease type you'll have available is Bacteria. Start the game on casual. Since you don't have the additional genes unlocked, just play this game to get used to the way things operate and how it works. When the world is fully infected, save. Start evolving your kill symptoms now, (the ones that increase the "lethality" bar in the evolution screen) and wait until there are very few people left alive. At this point, save again. With that done, finish the game. You'll receive a gene for winning. Now, load that last save that you made. Keep waiting out for those last few people to die, ending the game. Each time, you'll get yourself another gene. This is by far the fastest and easiest way to unlock all of your genes, so we can get to the fun stuff.

With all the genes unlocked, start up a Bacteria run on Mega-Brutal. Use the following set up:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Now, start in China. Evolve Water and Insect I as soon as you possibly can. This will unlock:

Evolve your disease

Evolve your disease to become stronger

Evolve your disease
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Now when China gets pretty infected and you have amassed some points, evolve the following symptoms in the following order:

Cysts
Coughing
Nausea
Rash
Anemia
Vomiting

Now that coughing and vomiting have been combined, you may see a pop-up concerning the projectile vomiting combo and unlocking:

Long Shot

Discover the Projectile Vomiting combo

Long Shot
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Pneumonia
Sneezing
Sweating
Abscesses
Hyper Sensitivity
Hemophilia

After evolving hemophilia, you are likely to get a pop-up at some point stating that you discovered profuse bleeding, unlocking:

Red Rain

Discover the Profuse Bleeding combo

Red Rain
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Water II
Insect II

If China is fully infected and all the islands (Greenland, Iceland, Madagascar, Caribbean, Phillippines, etc) have their ports open, SAVE here. Now evolve:

Diarrhea

With diarrhea and sneezing added together, you can get the Oops symptom combo for:

Uh Oh

Discover the Oops symptom combo

Uh Oh
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Pulmonary Edema
Skin Lesions
Drug Resistance I
Bacterial Resilience I, II, and III

Now that you have some lethality and infected countries, you may get pop-ups about the Olympics and RMS watch list. These are random but appear very frequently, you will see them eventually and unlock:

Olympic Spoiler

Help the Olympics go viral in the UK

Olympic Spoiler
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

RMS Watch List

Get your Plague on the RMS Watch List

RMS Watch List
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Drug Resistance II
Genetic Hardening I and II
Air I and II
Insomnia

With the insomnia added in to the anemia, the game may bless you with the walking dead combo and:

Brainzzzz

Discover the Waking Dead combo

Brainzzzz
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Paranoia
Seizures
Insanity
Necrosis
Paralysis

At this point, you may see a pop-up about a nuclear meltdown. This one is kinda tough and less likely on the RNG side of things, but you will get it eventually:

STALKERs delight

Cause a nuclear meltdown

STALKERs delight
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Coma

At this point, you should be a very lethal bacteria. If any of the islands close their ports before becoming infected, reload your save. Save again if the cure is low and all the islands are infected. Use your remaining points on Genetic Reshuffles when the cure rate starts to surpass 50%. Speaking of, popping your first blue cure bubble will net you:

Bottle Smasher

Smash a Blue cure bubble and slow down the Research Team

Bottle Smasher
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Once the game is complete, you'll unlock:

The End Plague

Win one game with any disease type and any difficulty

The End Plague
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Bacteria Master

Beat Bacteria on mega-brutal difficulty

Bacteria Master
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Bacteria Victory

Win a game with Bacteria on Normal Difficulty or higher

Bacteria Victory
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Now, start up another Bacteria run on casual with the following genes:

Cytochrome Surge
Genetic Mimic
Aerocyte
Xerophile
Translesion

Start in Saudi Arabia and evolve the following:

Rash
Sweating
Skin Lesions
Water I
Air I
Insect I
Drug Resistance I
Water II
Air II
Insect II
Cold Resistance I
Cold Resistance II
Coughing
Sneezing
Nausea
Vomiting
Genetic Hardening I
Necrosis
Diarrhea
Dysentery
Pulmonary Edema
Pulmonary Fibrosis
Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging

This should allow you to speed through the rest of the population, quickly infecting and killing everyone in under a year for:

Insane Bolt

Sprint to victory and set a world record by winning the game with Bacteria in under 365 days

Insane Bolt
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.Time/Date - These achievements require you to play the game or perform actions at certain times, within a time limit, or on specific dates.

With all that out of the way, let's work on all the Bacteria combos. All of the following are done on Bacteria on casual difficulty. Start anywhere and use any genes with the following symptoms. After evolving them all, SAVE. Devolve any other symptoms that may mutate. Keep reloading the save until the achievement unlocks.

Blood I
Blood 2
Insect I
Insect 2
Extreme Hematophagy
Drug Resistance I and II

Eventually you will unlock:

Contaminated Package

Let humans spread the disease via blood transfusion

Contaminated Package
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Next game, set it up with the following genes:

ATP Boost
Creationist or Genetic Mimic
Aquacyte
Extremophile
Trans-Stasis

Start in India and evolve:

Water I
Air I
Water II
Air II
Extreme Bioaerosol
Livestock I
Livestock II
Cold Resistance I
Drug Resistance I
Cold Resistance II
Drug Resistance II
Genetic Hardening I
Genetic Hardening II
Coughing
Pneumonia
Nausea
Vomiting
Diarrhea
Insomnia
Sneezing

You should now unlock:

Oink oink

Discover the Swineflu Combo

Oink oink
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Now, use the following genes for this last combo:

Metabolic Jump
Genetic Mimic
Aerocyte
Xerophile
Sympto-Stasis

Start in India and evolve:

Blood I
Water I
Insect I
Bird I
Drug Resistance I
Genetic Hardening I
Coughing

Wait for a large portion of infection in India and accumulate at least 55 DNA points. After you get the points, SAVE. After saving, devolve all symptoms and evolve the following:

Insomnia
Paranoia
Seizures
Insanity
Dysentery
Diarrhea

Devolve dysentery, seizures, paranoia, and insomnia so that the only 2 symptoms remaining are insanity and diarrhea. Eventually, you'll get the pop-up and unlock:

Brown Streets

Discover the Public Defecation combo

Brown Streets
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Start up another game on Normal with any genes, beginning in China. Don't evolve anything, just simply wait until you see some news about the UK voting on "Brexit" in a referendum. If you don't see it before the UK becomes infected, restart. Once it does, make a save. Get the UK infected by evolving transmissions or simply waiting for the bacteria to reach the British Isles. Once it does, evolve:

Paranoia
Insomnia
Cold Resistance I and II

Devolve anything that comes up, then just wait until your bacteria triggers a "Soft Brexit" for:

Soft Brexit

Help Britain softly leave the EU

Soft Brexit
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Load up your save and infect the UK again. This time, evolve:

Insomnia
Paranoia
Cysts
Hypersensitivity
Cold Resistance I

Same deal, just wait things out a bit until you trigger "Hard Brexit" for:

Hard Brexit

Encourage Britain to have a 'hard' Brexit

Hard Brexit
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Now load the save, infect UK, and this time evolve:

Insomnia
Paranoia
Seizures
Insanity
Cysts
Hyper Sensitivity

Wait until the pop-up indicating a Brutal Brexit for:

Brutal Brexit

Put Britain on the road to madness when it leaves the EU

Brutal Brexit
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Last and least, load up the save again. Infect the UK and evolve:

Water I and II
Cold Resistance I and II
Rash
Sweating
Skin Lesions
Necrosis

Once the UK has been fully infected, Brexit will sadly be cancelled. This will give you:

No Brexit

Stop Britain leaving the EU

No Brexit
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With bacteria out of the way, time to move on to the next plague. Start up virus on Mega-Brutal with the following genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Water/Insect I

Nausea
Coughing
Rash
Cysts
Anemia
Vomiting
Pneumonia
Sneezing
Sweating
Hyper Sensitivity
Abscesses
Hemophilia
Water II
Insect II
Cold Resistance I
Heat Resistance I
Drug Resistance I
Cold Resistance II
Heat Resistance II
Drug Resistance II
Environmental Hardening
Diarrhea
Dysentery
Skin Lesions
Pulmonary Oedema
Necrosis
Genetic Hardening I
Genetic Hardening II
Insomnia
Paranoia
Seizures
Insanity
Paralysis
Coma

Keep evolving lethal/infectious symptoms until you win for:

Virus Master

Beat Virus disease type on mega-brutal difficulty

Virus Master
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Virus Victory

Win a game with Virus on Normal Difficulty or higher

Virus Victory
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Now moving onto fungus. Fungus is the most luck based pathogen in the entire game, and for good reason. Spreading on its own is incredibly slow, and utilizes its special spore ability to infect countries at random. Save before you use some, and just keep trying until you have lots of islands infected. Start fungus on Mega-Brutal with:

ATP Boost
Genetic Mimic
Suppression
Urbophile
Patho-Stasis

Start in Saudi Arabia and evolve:

Water I
Bird I
Water II
Cold Resistance I and II
Drug Resistance I
Heat Resistance I
Drug Resistance II
Spore Burst I, II, III, IV, V, VI
Spore Eruption
Genetic Hardening I and II
Rash
Sweating
Skin Lesions
Necrosis
Insomnia
Paranoia
Seizures
Cysts
Hyper Sensitivity
Paralysis
Coma
Coughing
Pneumonia
Bird II
Rodent I

SAVE now if you'd like, using the last spore bursts to infect the remaining islands.

Spore Burst I, II, III, IV, V, VI
Spore Eruption 2

As long as all of the islands are infected or at least have open ports, proceed on with...

Total Organ Failure
Genetic Reshuffle I, II, and III

Once everyone is dead, you shall unlock:

Fungus Master

Beat Fungus disease type on mega-brutal difficulty

Fungus Master
3 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Fungus Victory

Win a game with Fungus on Normal Difficulty or higher

Fungus Victory
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Next up is the Neurax Worm, the easiest disease type by far. Neurax has a completely different strategy to achieve easy victory, so get used to this setting. It will be used a LOT in scenarios. Use the following genes:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I

Trojan Planes are new to the Neurax plague, and are a life saver. Once enough of a country is infected, a plane icon pops up. Grab and place it above another country and let it go, automatically infecting that country. Always start with islands, moving onto any uninfected countries, and using the remainder on countries that need a little more infection in them. Start with the island countries, even a country without an airport can take a plane. Greenland, Iceland, Philippines, Caribbean, etc. Then shift focus onto any uninfected country, cure developers, and places that just need a little boost. Using your first plane will unlock:

Trojan Horse

Create a trojan plane and use it to infect a new country with the Neurax Worm

Trojan Horse
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.


Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Now just keep evolving transmissions until the world is infected, you don't need any more symptoms. Once the world is infected, you win. No killing necessary with Transcendence. This will get you:

Neurax Master

Beat Neurax Worm disease type on mega-brutal difficulty

Neurax Master
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Neurax Worm Victory

Win a game with Neurax Worm on Normal Difficulty or higher

Neurax Worm Victory
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Assuming Direct Control

Win a game by enslaving humanity with the Neurax Worm

Assuming Direct Control
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Start up another Neurax game, this time on casual with the following setup:

Metabolic Jump
Genetic Mimic
Aquacyte
Extremophile
Patho-Stasis

Start in India and evolve:

Concertina Locomotion
Neural Breach
Cerebral Tendrils
Frontal Mesh
Adrenergic Constriction
Anxiolytic Infusion
Psychosis
Cold, Heat, and Drug Resistance I and II
Environmental Hardening

Trojan Planes I

Speed things up until the infection becomes rapid, using the planes to infect remaining countries more quickly. Once most of the world is infected, evolve...

Despair
Suicide

This should get you:

Worm Food

Win a game by eradicating humanity with the Neurax Worm

Worm Food
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next up is Parasite, start a Mega-Brutal game with these genes:

Metabolic Jump
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in Saudi Arabia and evolve:

Rash
Sweating
Skin Lesions
Water I
Insect I
Air I
Drug Resistance I
Water II
Air II
Fever
Insect II
Cold Resistance I and II
Genetic Hardening I
Coughing
Sneezing
Drug Resistance II
Pneumonia
Nausea
Vomiting
Pulmonary Fibrosis
Necrosis
Immune Suppression

Wait for a high amount of infection before evolving:

Total Organ Failure
Diarrhea
Pulmonary Edema
Dysentery
Genetic Reshuffle I, II, III (as necessary)
Insanity
Coma
Inflammation

This will earn you:

Parasite Master

Beat Parasite disease type on mega-brutal difficulty

Parasite Master
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Parasite Victory

Win a game with Parasite on Normal Difficulty or higher

Parasite Victory
3 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Moving on to the Prion. Since the Prion is very hard to detect but also slow moving, it makes it a tough win on Mega-Brutal but a perfect choice for a lot of the RNG encounters that may take some time to pop up for you. Let's get the hardest part out of the way first though, so fire up Prion on Mega-Brutal difficulty with:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Rash
Nausea
Coughing
Cysts
Anemia
Hemophilia
Hyper Sensitivity
Abscesses
Pneumonia
Sneezing
Sweating
Vomiting
Diarrhea
Skin Lesions
Water I
Insect I
Water II
Insect II
Drug Resistance I and II
Cold/Heat Resistance I and II
Insomnia
Paranoia
Seizures
Insanity
Paralysis
Coma
Neural Atrophy I, II, and III
Genetic Hardening I and II
Total Organ Failure

If the cure is progressing quickly, use Genetic Reshuffles until victory for:

Prion Master

Beat Prion disease type on mega-brutal difficulty

Prion Master
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Prion Victory

Win a game with Prion on Normal Difficulty or higher

Prion Victory
4 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Now, time to work some RNG magic. Begin Prion on casual, any genes you so desire. Start in Saudi Arabia and evolve:

Air I and II
Water I
Neural Atrophy I, II, and III
Drug Resistance I
Genetic Hardening I and II
Coughing
Sneezing
Pneumonia
Cysts
Hyper Sensitivity
Abscesses
Insomnia
Paranoia

Now the waiting game begins. SAVE here and devolve anything that may mutate, using Genetic Shuffles if the cure starts to creep up to 75% or higher. Wait until you see a pop-up saying "CDC teams hunt Patient Zero". That's the first phase. Shortly after this, you should get another pop-up saying that "CDC teams close in on Patient Zero". Once they're close to discovering them, evolve:

Anemia
Hemophilia
Internal Hemorrhaging
Hemorrhagic Shock

This is enough to kill people off at a fast enough rate to make discovery of Patient Zero impossible, but not destroy the world. After a few billion deaths, you should get the final pop-up stating that "The CDC failed to identify Patient Zero", unlocking:

Patient Who?

Stop the CDC finding Patient Zero

Patient Who?
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Now it's time to start tackling a few things at once. Begin a new game, Prion, on casual with the following genes:

Catalytic Switch
Genetic Mimic
Aerocyte
Extremophile
Sympto-Stasis

Start in the USA and evolve:

Drug Resistance I and II
Air I and II
Cold Resistance I
Water I and II
Extreme Bioaerosol
Neural Atrophy I,II and III
Genetic Hardening I and II

SAVE here, as this will create a divergent path where you can load the game and get multiple achievements without going back to evolve all that beginning stuff. Now, depending on whether you want the USA to nuke China or Russia, evolve either Bird I and II for China or Cold Resistance II for Russia. Accumulate 55 DNA points, then evolve:

Insomnia
Paranoia
Inflammation
Seizures
Insanity
Dysentery

You will see a pop up saying “iCure device announced”. Hold off until you see the 2nd pop-up announcing that "iCure device released globally". Once you have that, evolve sweating. Pretty soon you'll see a pop-up about how the touchscreens of the iCure are malfunctioning due to excessive sweating, unlocking:

Touchscreen Trash

Disrupt the iCure and stop it helping cure research

Touchscreen Trash
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After this, once things continue for a bit, you'll see a pop-up saying “Space cure mission planned”. Since everyone is pretty much already infected, just wait until you see the pop-ups announcing the launch and failure of the space cure mission. After the failure, you'll unlock:

Plague in Space

Infect astronauts before they launch a space mission

Plague in Space
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You will see pop-ups saying “US President taken ill”, followed by “New President of USA selected”. Depending on which evolution you chose after your save, you'll see “USA threatens Russia/China”. Now evolve insanity and paralysis. After a short period, you'll see Spalin nuked Russia/China because she was insane and the generals were paralyzed. Now simply reload your save, evolve the other ability, then continue on to nuke the other country for:

Russian Nuclear Retaliation

Make the USA nuke Russia

Russian Nuclear Retaliation
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Chinese Nuclear Retaliation

Make the USA nuke China

Chinese Nuclear Retaliation
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This last one is rather specific, and requires your disease to remain undetected the entire time. Start Prion on normal with the following genes:

Metabolic Hijack
Creationist
Native Biome
Hydrophile
Patho-Stasis

Start in the Caribbean, devolving any and all symptoms that may appear. Once your little island is fully infected, evolve nausea. Keep devolving all else, until you see "Rumors of mystery plague in Caribbean" appears. "Mystery Plague has been recommended to be investigated in Caribbean" should appear shortly after, followed by "Riots in Caribbean" a bit later on. This is what forces governments to intervene, ending with the final pop-up, "Mystery Plague is real" for:

Peer Pressure

Have your plague discovered after riots force a government investigation

Peer Pressure
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With all of that out of the way, play through Necroa Virus on normal however you see fit. I have a whole section of this guide dedicated to the individual Necroa achievements, so do some practice runs of that scenario as experimentation to get used to the idea of playing with zombies. After evolving Cytopathic Reanimation, victims of the virus will start to turn into zombies. The special abilities opened up by zombies allow you to move hordes around and resurrect the dead. You can also evolve zombie combat abilities, making them deadlier and more difficult to kill. Once the entire world is almost dead, SAVE. Finish the game and get yourself a new zombie gene. Load that save a few more times to unlock all of the genes for Necroa, so that you are well prepared for the next section. After getting all of your genes, move on to Nano-Virus on Mega-Brutal difficulty with the following genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Sympto-Stasis

Start in Saudi Arabia and immediately evolve:

Code Fragment Interception
Coughing
Cysts
Hyper Sensitivity
Insomnia
Paranoia
Rash
Sweating
Nausea
Vomiting
Pneumonia
Sneezing
Abscesses
Aaemia
Hemophilia
Code Segment Interception
Water and Insect I
Paralysis
Coma
Skin Lesions
Diarrhoea
Water/Insect II
Radical Elements Stabilised
Drug Resistance I
Genetic Hardening I and II
Drug Resistance II
Seizures
Insanity
Cold Resistance I and II
Necrosis
Dysentery
Encryption Breached
Replication Factory Overload
Genetic Re-Shuffles I, II, and III
Heat Resistance I and II

Wait until you get the pop-up announcing "There are no healthy people left in the world". Once everyone is infected, start evolving Total Organ Failure and everything else that makes the lethality jump up high. Once almost everyone is dead, evolve Broadcast Interceptor Overload to keep the cure way down. Completing this will unlock:

Nano-Virus Master

Beat Nano-Virus disease type on mega-brutal difficulty

Nano-Virus Master
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Nano-Virus Victory

Win a game with Nano-Virus on Normal Difficulty or higher

Nano-Virus Victory
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Moving onto the next one, start up Bio-Weapon on Mega-Brutal with these genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Patho-Stasis

Begin your weapon in India and evolve:

Gene Compression I, II, and III
Deactivated Modified Genes I

If you start to kill people, evolve Deactivated Modified Genes II and III respectively.

Coughing
Pneumonia
Sneezing
Cysts
Hyper Sensitivity
Abscesses
Water/Air I and II
Extreme Bioaerosol
Drug Resistance I and II
Cold Resistance I and II
Heat Resistance I and II
Environmental Hardening
Genetic Hardening I and II
Nucleic Acid Neutralisation I, II, and III

Once everyone on earth is infected, Unlock Annihilation Gene and:

Genetic Reshuffles I, II, and III
Paralysis
Coma
Insomnia
Paranoia
Seizures
Insanity

Finishing here will unlock:

Bioweapon Master

Beat Bioweapon disease type on mega-brutal difficulty

Bioweapon Master
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Bio-Weapon Victory

Win a game with Bio-Weapon on Normal Difficulty or higher

Bio-Weapon Victory
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Now with that over with, you're going back to the learning phase again with the last virus, Simian Flu. There are 2 banks of genes to unlock here, so start up a run of this scenario, learning the new techniques and determining your preferred method of using apes to spread the infection.

I have a whole page on the specifics of this plague type, but in order to get through the first playthrough and unlock all the genes, using the following method. Start up a game on Casual and start your game in Saudi Arabia. From you'll want to evolve;

Pharyngitis
Sneezing
Air I and II
Drug Resistance I
Cold Resistance I
Water I and II
Extreme Bioaerosol
Drug Resistance II

From here, make a SAVE, then wait. Don't evolve anything else, and devolve anything you can up to costing 5 DNA points. Wait until the whole world is infected, although when the cure research reaches 25%, evolve Simian Neuro-Genesis and make another SAVE. Continue waiting for the world to be fully infected. Once it is, evolve the following;

Neuro-Enhancement I, II and III
Total Brain Death

After that, focus on evolving as many lethal symptoms as possible, especially the following;

Pulmonary Hemorrhage
Coma

Any remaining DNA you earn is to be spent on Genetic Reshuffles. Now simply wait until only a few thousand humans are left alive and make another SAVE, and let everyone die. Simply reload the save, rinse and repeat to unlock all the new Simian Flu genes. Then head to the Simian Flu page in this guide to work on the rest of the Simian achievements. You'll need to play through again on normal to unlock the following achievement:

Unlock Cheatmodes

Unlock the cheats by winning a game on Normal for ALL disease types

Unlock Cheatmodes
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Now that we have finished the base campaign, it's time to move onto the specific viruses.

The Necroa Virus is a special disease type that adds in the feature of zombies to gameplay. The virus itself gets cured incredibly quickly, and the usual strategy is to create a large number of zombies capable of killing/infecting others before the cure is created. There are a large number of RNG pop-up scenarios that only appear for the Necroa Virus, so let's focus on those first. Start up the game on casual with the genes:

ATP Boost
Creationist
Aerocyte
Xerophile
Spliced Activation

Start in Ukraine and within the first 60 days evolve the Saliva I and Zoonotic Shift transmissions. If you don't have the DNA to evolve these within the first 60 days, restart. You will soon see a pop-up stating that a tourist in Chernobyl is recovering from a wild animal attack. SAVE here. Devolve anything else that comes up until you see a pop-up about a Chernobyl group being attacked by wild dogs, followed by another stating that the military was deployed in Chernobyl due to the rabid animals. Save up 45 DNA points and evolve:

Insomnia
Fever
Photophobia
Delirium
Cytopathic Reanimation

In some games, the zombie population grows so quickly, the Ukraine government falls and this achievements necessary story steps stop working. To prevent this, evolve the Horde Instinct ability. Then work to send zombies out of the country to other locations as need be to keep the population down. Moving your first group of zombies out into a surrounding country will earn you:

Flash Mob

Successfully use the Zombie Horde active ability

Flash Mob
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SAVE here. Now it's a waiting game for the remaining pop-ups. You can use your spare points to buy Re-Animate, bringing zombies back from the dead in a country or two for:

I'll Be Back

Successfully use the Zombie re-animate active ability

I'll Be Back
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Soon, you'll get a pop-up about how the plague originated in Chernobyl. Once the team continues their research, you'll get information on how Chernobyl animals are infected with the plague. Very shortly after, you'll get one more stating the Chernobyl animal tests were successful. Now evolve:

Blood I
Air I
Blood II
Air II
Air III

Your final pop-up will soon appear, granting you:

Breathe Deep

Infect the Chernobyl research team

Breathe Deep
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Now you can use the remaining time to get some other stuff. Evolve your zombies' fighting abilities and horde size, then move your zombies into the nearest Z-Com based country. Keep moving forces in until the base is destroyed, granting you:

Z Com: Enemy Undead

Destroy a Z Com fortress

Z Com: Enemy Undead
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Keep moving your horde around, killing and infecting new countries. As soon as you can, evolve:

Anaerobic Resuscitation
Enhanced Sensory Integration
Hyperosmia
Temporal Lobe Manipulation
Cathemeral Shift

These new symptoms grant you the Blood in the Air combo and:

Jaws

Discover the Blood in the Air combo

Jaws
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Evolve:

Enhanced Motor Control
Peptide Surge
Dermal Calcification
Cranial Elephantitis

This will get you:

Use your head

Discover the Cranial Dispersion combo

Use your head
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Evolve:

Structured Travel
Dyskinetic Movement
Echopraxia
Engorged Quadriceps

This will give you:

Runner

Discover the Runner combo

Runner
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Load your save. Wait until you see that Chernobyl is being investigated, and at this point immediately devolve Zoonotic Shift. Shortly thereafter, another pop-up should appear, saying there is no link to the animals spreading this disease for:

Hide and Seek

Prevent link with Chernobyl exclusion zone

Hide and Seek
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Load your save again. Wait for all the pop-ups to take their natural course, up until you see the one about the animals being captured by the military for testing. Evolve Bat I and II now, and wait for the final pop-up about the animals being too dangerous to test for:

Test This!

Force Chernobyl research to be put on hold

Test This!
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With that done, you can move on. Start the game on casual with:

ATP Boost
Creationist
Native Biome
Zerophile
ThermoNecro

Start in the UK. Within the first 60 days, evolve the Segmented Genome and Saliva I transmissions. A pop-up message should appear shortly about how PfiGlax has a cure for AIDS. After that, two side stories should appear in red, "Blog claims PfiGlax struggling with virus mutation", and "PfiGlax executives in huge share sell-off". After this one occurs, evolve:

Insomnia
Fever
Photophobia
Delirium
Cytopathic Reanimation

SAVE here. Now you should see another pop-up about how PfiGlax is linked to the virus.

Now you can evolve:

Autolytic Delay
Putrefactive Resistance
Liquiefactive Resistance

Shortly after, you'll get your final pop-up and:

Banana Skin

Prevent PfiGlax modifing the Necroa Virus

Banana Skin
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Now you can evolve:

Anaerobic Resuscitation
Enhanced Motor Control
Peptide Surge
Acidic Reflux
Naja Mortis
Autothysis
Regenerative Activation
Ambush Predation
Liquefactive Necrosis

This will earn you the Boomer combo and:

Boomer

Discover the Boomer combo

Boomer
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Finish up this set by evolving:

Enhanced Sensory Integration
Temporal Lobe Manipulation
Cathemeral Shift

This shall earn you:

Walking Contradiction

Discover the Walking Contradiction combo

Walking Contradiction
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Now, reload your save. Wait until you get a pop-up about PfiGlax manipulating your virus. Evolve:

Heat/Cold Resistance I
Mummification

Soon after this, you'll get another pop-up and:

Don't Ask Me

Make the PfiGlax modification project fail

Don't Ask Me
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Reload your save again. Evolve:

Drug Resistance I
Genetic Hardening
Genetic Reshuffle I and II

Now you'll get another pop-up about there being no link to PfiGlax. This will grant you:

Due Diligence

Stop PfiGlax finding a link to the Necroa Virus

Due Diligence
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Start a new game on Necora Virus normal difficulty. For this, any of the genes are acceptable so just run with whatever you're most comfortable with. The only one I'd definitely recommend is ATP Boost.

Start in the USA and evolve Saliva Transmission and Drug Resistance I within 60 days. If all goes well, you'll get a pop-up regarding DarkWater very early on. SAVE here. Wait for the pop-up about DarkWater denying a weapons facility breach, then another shortly after regarding DarkWater shutting down said facility. Now evolve:

Insomnia
Fever
Photophobia
Delirium
Cytopathic Reanimation

Wait for a pop-up message about DarkWater admitting they created the virus. SAVE again here.

We need to wait for another popup message this one is about how DarkWater successfully analyzes the virus and they're confident it will help fight the zombies. Now evolve Genetic Hardening, waiting until the last pop-up appears for:

Dead End

Stop DarkWater from discovering a Necroa Virus weakness

Dead End
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Since you have some time and DNA, evolve:

Anaerobic Resuscitation
Enhanced Sensory Integration
Enhanced Motor Control
Peptide Surge
Acidic Reflux
Naja Mortis

You shall be given the Spitter combo and:

Spitter

Discover the Spitter combo

Spitter
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Finish up this run with the following symptoms:

Enhanced Motor Control
Masticatory Tension
Anabolic Boost
Peptide Surge
Dermal Calcification
Cranial Elephantitis
Bone Dysplasia

The Tank combo grants you:

Tank

Discover the Tank combo

Tank
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Now reload your last save. Evolve the Segmented Genome transmission.

Once you get the pop-up, you'll unlock:

Non Starter

Stop DarkWater from analysing the Necroa Virus

Non Starter
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Reload your last save again. Once you see DarkWater has successfully analyzed the virus, evolve the following symptoms:

Anaerobic Resuscitation
Enhanced Motor Control
Peptide Surge
Acidic Reflux
Naja Mortis
Autothysis

You should get a message about DarkWater Z-Rest device test and another pop-up about it failing, once you get that you will unlock the final DarkWater achievement:

Big Bang

Kill the DarkWater research team

Big Bang
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Start up another game on casual with the following genes:

ATP Boost
Genetic Mimic
Aquacyte
Extremophile
Dopamine Inhibitor
Start in Egypt and evolve:
Saliva I
Heat Resistance I

You will now wait out a series of a few pop-ups, stating there was a tomb found in the pyramid of Giza. Wait until you get the news banner announcing that a body inside the pyramid has odd bite marks on it. This will come up after the hieroglyphics warn of an ancient plague. This is where you want to SAVE. Now evolve:

Insomnia
Fever
Photophobia
Delirium
Cytopathic Reanimation
Horde Instinct
Horde Mentality
Horde Vocalisation
Horde Pheromones
Structured Travel

Now keep an eye on Egypt, moving hordes of zombies OUT of the country if their number surpasses 4 million. That could lead to a government collapse, which is unwanted. Keep zombie numbers limited until you get the pop-up saying the plague escaped from the tomb inside the pyramid. A pop-up will appear saying that "Archaeologists say that Necroa may have escaped from a secret tomb inside The Great Pyramid of Giza."

Devolve Heat Resistance I
Evolve Cold Resistance I and II

The tests will show the disease is more resilient to cold, and unlock:

Getting Colder

Trick the Egyptian DNA tests

Getting Colder
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Load your save and evolve:

Insomnia
Fever
Photophobia
Delirium
Cytopathic Reanimation

Now wait for some pop-ups, the first few about the pyramid and how the virus originated from the tomb in it. The one you want to see is when reports confirm the virus originated from the tomb. The next one will be about a planned investigation into the tomb. Now evolve:

Cold Resistance I
Mummification
Regenerative Activation
Ambush Predation
Liquefactive Necrosis
Regenerative Biosynthesis
Epidermal Digestion
Cranial Metastasis
Autolytic Delay
Putrefactive Resistance
Liquefactive Resistance

Now just wait for the final pop-up about the expedition being a failure for:

It's a Trap!

Wipe out the Giza expedition

It's a Trap!
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Load up your save again and evolve:

Zoonotic Shift
Insect I
Rodent I and II

Wait for the pop-up message that says your plague's DNA supports Giza link. Then evolve:

Autolytic Delay
Putrefactive Resistance
Liquefactive Resistance

Wait for the pop-up message stating the Giza pyramid expedition was successful. Now evolve:

Symptoms Anaerobic Resuscitation
Enhanced Motor Control
Peptide Surge
Dermal Calcification
Cranial Elephantitis

The next pop-up will talk about the military losses and earn you:

Revenge of Osiris

Invalidate the knowledge of the pharaohs

Revenge of Osiris
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Start a new game on casual with the genes:

ATP Boost
Genetic Mimic
Aquacyte
Xerophile
ThermoNecro

Start in India, SAVE, and evolve:

Hyper Salvation
Polyphagia
Gastroenteritis
Autophagia
Cannibalism

That's all there is to it. Now just wait for the combo to pop up for:

Tasty

Discover the Bath Time combo

Tasty
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Load your save and evolve:

Zoonotic Shift
Bat I
Bat II
Insomnia
Fever
Photophobia
Delirium

Save up 50 DNA before proceeding to evolve:

Cytopathic Reanimation
Anaerobic Resuscitation
Enhanced Sensory Integration
Temporal Lobe Manipulation
Cathemeral Shift
Vampiric Hunger

As long as all of this stuff gets unlocked before the cure is complete, you should get the pop-up about infectious bats and:

Is it a bird?

Discover the Vampire Bat combo

Is it a bird?
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Load your save again. This time, follow the zombie evolution tree to make the undead, and just wait. Wait and wait until you get a pop-up about a boom in the insect population. Once you see this, evolve Zoonotic Shift for:

Who needs DEET

Avoid insect bites

Who needs DEET
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Fire up a game on Mega-Brutal, this one is gonna be tough. Equip the following genes:

ATP Boost
Darwinist
Suppression
Xerophile
Spliced Activation

We'll be starting our plague in Saudi Arabia and evolving:

Hyper Salivation
Polyphagia
Gastroenteritis

Try to avoid sterilization events, restart if one happens to pop up. You want as many countries infected and prime for zombification as possible. Continue by evolving:

Blood I
Air I and II
Cannibalism
Cytopathic Reanimation
Blood II
Air III
Anaerobic Resuscitation
Enhanced Motor Control
Peptide Surge
Acidic Reflux
Naja Mortis
Autothysis

Those symptoms place an emphasis on zombie combat, making the threat of Z-Com seem insignificant if you can get the numbers to combat them. Now, let's focus on getting those numbers up.

Horde Instinct
Stuctured Travel
Drifting Fermentation
Dyskinetic Movement
Echopraxia
Engorged Quadriceps
Horde Mentality
Horde Vocalisation
Horde Pheromones

This part of the strategy will dictate if you're going to be able to finish fast. Obviously, you'd want to send your zombie hordes to uninfected island countries first, then focus on Z-Com bases if possible. Pause the game if you plan to use multiple zombie hordes. Pausing could be of great help in planning where to send your zombies. Also note that when you use zombie hordes while the game is paused, the horde bubble won't appear yet, it'll only appear once you resume the game.

Greenland could be infected from Canada, Iceland, the USA, or even Brazil. Do this when one gets a heavy swarm of zombies first.

Madagascar is easily infected from East Africa or Saudi Arabia

Philippines can be easily infected through China. The same can be said for Japan and Korea.

Indonesia can be infected through India, and New Guinea through Philippines or Indonesia

Move zombies from Mexico to the USA and Caribbean, if necessary.

The European cluster countries will be hard to infect so be sure to send zombies there as soon as you can, especially if you notice a closure in land borders.

From Libya and Morocco, you could easily infect the southern part of the European countries(Spain, Italy, etc.)

From Turkey, you can infect Central Europe and Ukraine

From Russia, sending zombies to Finland is a very good idea.

You might also want to send zombies to Norway and Sweden from Canada and Iceland.

Finally, if you're close to Z-Com base, especially if it's the first one, send one or two hordes there immediately

You won't only have to move zombie hordes, but also evolve some more combat symptoms. This is totally up to you on when you think you need to evolve the following, so save up 40-50 points and get:

Dermal Calcification
Cranial Elephantitis
Bone Dysplasia
Masticatory Tension
Lumbrical Hypertrophy

If you're able to effectively move your zombies, you'll be able to destroy Z-Com easily. If Z-Com begins their base in Greenland, you're extremely lucky, because sending one zombie horde from a country with millions of zombies will quickly destroy Greenland. The smaller the country population, the more easily they can be destroyed by a few large hordes.

The worst place for Z-Com to start is in any country in Europe. Central Europe, Germany, Poland, and Spain all have huge populations, and zombies are often spread thin across the continent. The game is still totally winnable if Z-Com starts here, just try to kill them off quickly. Once the world has fallen into the jaws of the dead, you shall unlock:

Necroa Master

Beat Necroa Virus disease type on mega-brutal difficulty

Necroa Master
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The Glorious Dead

Win a game with the Necroa Virus

The Glorious Dead
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Now for the absolute worst one by far. You have to win this entire scenario without evolving Cytopathic Reanimation. That means even if it mutates on its own, you're screwed out of this one. Make a bunch of saves whenever you feel like you made progress, and be very patient about the pop-ups. It took me about 40 tries to get the first one. With that said, start a game on casual with the following genes:

Cytochrome Surge
Creationist
Aerocyte
Xerophile
None

Start in India and evolve:

Saliva I
Zoonotic Shift
Bat I

Keep an eye on the news banner and wait for the news to appear that says: "Colony of rabid bats triggers town evacuation". If this doesn't appear by the time shortly after India is completely infected, start over. This took me 40+ tries to get.

Devolve Bat I

Evolve:

Drug Resistance I
Genetic Hardening
Genetic Re-Shuffle I and II

Wait for some more news about the WHO starting Rabies Eradication Initiative and the film about the rabies epidemic becoming a global hit. Once you get these, save up 70 DNA and evolve:

Gastrointestinal Expansion I and II
Cold Resistance I and II

Wait until the world is completely infected and evolve:

Insomnia
Fever
Photophobia
Coma
Acute Encephalitis
Hyper Salivation

You'll get a pop-up stating that your disease is a form of rabies. Once you do, immediately devolve Zoonotic Shift. Another pop-up will appear declaring the link to rabies to be false. After seeing this pop-up, the cure should slow down significantly and after a while should stop completely. You are now free to eradicate humanity without the use of zombies. The whole process of killing takes a long time, a really really long time. SAVE here. This is where your patience will be slightly tested. Make sure that Cytopathic Reanimation does NOT evolve under my circumstances, reload your save if it does. Just put the game on max speed and ride it out. Once everyone is dead, you'll unlock:

Not Another Zombie Game

Win a game with the Necroa Virus without making a single zombie

Not Another Zombie Game
3 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Congratulations on completing Necroa! Now onto the even bigger pain in the ass, the Simian Flu...

The Simian Flu is another virus that relies on the movement of infected hostile bodies in order to spread. This time we're using apes instead of zombies, but the same principles apply. The largest difference is that apes can create colonies that are essentially DNA factories. You're gonna be using this a lot, so make sure you're aware of the tactic. Start up your first game on casual with the genes:

ATP Boost
Ion Surge
Aquacyte
Extremophile
Together Strong

Devolve any symptom that mutates up until it costs 5 DNA to devolve, once you reach that point stop devolving. Devolving in the early stages will help you evade world governments and prevent them from taking action against your apes. This also reduces the chances of your one and only colony being destroyed by drones.

Start in Greenland, and evolve:

Simian Neuro-Genesis. This will soon unlock:

Great EscApe

Break apes out of the primate shelter

Great EscApe
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Ape Colonies. Base your colony in Greenland to unlock:

Family. Future.

Create an ape colony to bring intelligent apes together

Family. Future.
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Social Cohesion
Cognitive Shift
Education

SAVE

Water I and II
Air I and II
Extreme Bioaerosol
Drug Resistance I
Heat Resistance I
Primal Awareness
War Paint
Covert Expertise
Neuro-Enhancement I, II, and III
Total Brain Death
Photophobia
Subconjunctival Bleed
Subconjuctival Hemorrhage
Blindness

You will soon get a pop-up for this combo and:

Blind Genius

Discover the Blind Genius Combo

Blind Genius
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Meningitis
Coma
Hydrocephalus
Hypocoagulability

If you have spare DNA, go crazy on murder symptoms. Once everyone is dead, you shall unlock:

An Ape is for Life…

…Not just for Christmas

An Ape is for Life…
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Now start up another game on casual with the following genes:

ATP Boost
Ion Surge
Native Biome
Extremophile
Together Strong


Start in Central Africa and devolve any symptoms that mutate apart from what I mention. Evolve:

Simian Neuro-Genesis
Ape Colonies (start your colony in Central Africa)
Social Cohesion
Cognitive Shift
Education
Primal Awareness
War Paint
Cover Expertise

Wait until the number of apes in Central Africa reaches 400,000.

Ape Migration
Scouts
Path Finders

The other apes of the world will start to congregate in Central Africa. Wait for 500,000 to reach your colony to unlock:

Apes. Together. Strong.

Gather 500,000 apes in a single country

Apes. Together. Strong.
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Evolve Organized Travel and move your colony to East Africa for:

The Traveller

Move intelligent apes to a new country

The Traveller
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Now wait for the remainder of the worlds apes to become intelligent due to the virus for:

Not Just a Pretty Face

Make every ape in the world intelligent

Not Just a Pretty Face
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With every ape intelligent and infected, devolve Simian Neuro-Genesis. This will kill all the apes and grant you both:

Did I mean to do that?

Reverse Simian evolution

Did I mean to do that?
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Shouldn't Keep Pets

Allow all the apes to die

Shouldn't Keep Pets
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Start up another game on casual with these genes:

ATP Boost
Ion Surge
Teracyte
Extremophile
Together Strong

I started my Simian Flu in Central Africa, devolving anything that mutates and evolving:

Simian Neuro-Genesis
Ape Colonies
Social Cohesion
Cognitive Shift
Education

Establish colonies in the following countries as soon as they become available to farm as much DNA as possible.

  • West Africa
  • East Africa
  • Sudan
  • India
  • China
  • Indonesia

Evolve:

Primal Awareness
War Paint
Covert Expertise
Water/Air I and II

Now just sit and watch the world pass you by. Your apes will get destroyed by Gen-Sys and the military. Just allow this to happen, it's part of the plan. When a drone strike wipes out one of your colonies, you'll get:

Attack of the Drones

Have a colony destroyed by a drone

Attack of the Drones
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Just keep waiting for the plague to be cured, without apes retaliating and attacking humans. Once the cure is close to complete you'll get:

The Future is Bright

End the game with apes and humans living together peacefully

The Future is Bright
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Start up a game on Mega-Brutal with these genes:

ATP Boost
Ion Surge
Aquacyte
Extremophile
Together Strong

Start in Central Africa and evolve:

Simian Neuro-Genesis
Joint Pain
Ape Colonies (plant it in Central Africa)
Inter-Genus Dissemination I and II
Cognitive Shift
Education

Make 2 new colonies, one in East and one in West Africa.

Sebaceous Excretion
Blood Gift
Cutaneous Transfer
Submissive Conception
Excrement
Social Cohesion

This combo will get you:

Do it like they do

Discover the Discovery Channel Combo

Do it like they do
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Make another 2 colonies, one in Sudan and the other in Angola.

Primal Awareness
War Paint
Covert Expertise
Drug/Cold Resistance I
Genetic Hardening I
Organized Travel
Logistics
Seafaring
Scouts

The introduction of scouts will unlock:

Rude Awakening

Discover the Rude Awakening Combo

Rude Awakening
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Send apes from Morocco to Brazil.

Ape Rampage

This combination will net you:

Ape's Creed

Discover the Assassin Combo

Ape's Creed
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Cold/Drug Resistance II

Create another colony in Egypt.

Genetic Hardening II

Wait for a pop-up stating that a new Gen-Sys lab is working on a cure. Once you see this, use Ape Rampage on the country where the Gen-Sys lab is located. This will destroy the lab, take some progress off the cure, and scare the local human population into attacking apes for:

Go Simian-faeces

Destroy a Gen-Sys lab

Go Simian-faeces
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ExterminApe

Scare humans into becoming hostile to apes

ExterminApe
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Homindae Bridge

This should get you:

Like flies round…

Discover the Fly Magnet Combo

Like flies round…
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Devolve joint pain and evolve:

Air/Water I and II
Extreme Bioaerosol
Primal Hunt
Photophobia
Subconjunctional Bleed
Subconjunctional Hemorrhage
Blindness

Use apes to infect any uninfected country. If there's still a lot of healthy humans left, evolve:

Blood I and II
Extreme Hemoaerosol

Once the world is heavily infected evolve:

Neuro-Enhancement I, II, and III
Total Brain Death
Hemorrhagic Shock
Internal Hemorrhaging
Meningitis

Use your remaining DNA to evolve lethal symptoms until victory, unlocking:

Simian Master

Beat the Simian Flu on mega-brutal difficulty

Simian Master
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Apes will Rise!

Destroy humanity with the Simian Flu and let the apes take over

Apes will Rise!
Offline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now for the real annoyance. This next achievement is incredibly finnicky, and will require multiple attempts, even if you're sure you "got" it. You need a hostile ape colony in the USA, as well as healthy humans in that country. The virus needs to be cured, but only after there are under 1.5 million humans left alive. Start a game on casual with:

ATP Boost
Ion Surge
Aquacyte
Extremophile
Together Strong

Start in the USA and devolve every symptom until the entire world is infected! Make sure to plan ahead and have enough DNA left every time you want to make an upgrade. You can tell exactly how much DNA you will need as it just goes up by one each time, starting at 0 for the first symptom devolution. Evolve:

Simian Neuro-Genesis
Ape Colonies also, then put a colony in the USA
Organized Travel

Now, while doing future upgrades, watch Mexico, you can highlight Mexico in Ape Mode and you can see as soon as there are any 'Smart' apes in Mexico. The moment you see any 'Smart' apes there, start sending them to these locations preferably in this order: New Zealand, New Guinea, Philippines, Japan, Madagascar, Finland, U.K., Iceland, Greenland, and then anywhere else that shows there are apes that aren't 'Smart' yet. Do NOT wait for Mexico to build up it's smart apes populatio as you won't be able to take advantage of Mexico to spread infected apes around the world as all the apes will leave.

Continue evolving:

Cognitive Shift
Education
Logistics
Seafaring
Horseback Riding
Social Cohesion
Primal Awareness
War Paint
Covert Expertise
Ape Rampage
Primal Hunt
Weapon Creation
Ape Migration
Scouts
Path Finders

As soon as your traveling Apes from Mexico get across to Africa, you should now be able to start placing colonies there. Place colonies in West Africa, Central Africa, East Africa, Sudan, India, China, and Indonesia in whatever order you can, just as soon as you can. If one of those countries doesn't have any infected apes to build a colony, you can just build a nearby colony then migrate to the target country. These upgrades are going to get expensive! My guess as to the DNA costs: 1st colony: 8 DNA; 2nd: 15 DNA; 3rd: 25 DNA; 4th: 40 DNA; 5th: 55 DNA; 6th: 75 DNA; 7th: 95 DNA; 8th: 130 DNA. Don't worry though, you're going to have a LOT of DNA; I had over 1300 DNA when I finished. If a drone targets a colony, move it out of harms way. Make sure you always have your USA colony moved back if necessary. Moving a colony to avoid a drone will grant you:

EvacuApe

Evade a drone attack

EvacuApe
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SAVE after placing your final colony. Evolve:

Air/Water I and II
Extreme Bioaerosol
Heat Resistance I
Drug Resistance I and II
Genetic Reshuffle I and II
Hardened Reshuffle

Be ready to destroy Gen-Sys labs! Rampage and destroy them as soon as they appear.

SAVE once the world is infected fully. Now evolve:

Neuro-Enhancement I, II, and III
Total Brain Death

What you're doing here is making the human's recognize they are dying, and need to cure the virus. Once the cure gets underway, or you start getting messages about countries falling apart, DEVOLVE any lethal symptoms! DN NOT KILL more than 2 billion people! Now, you wait. Watch the cure percentage climb slowly, immediately kill any Gen-Sys labs that show up with Rampage, and run away from Drones. You want the cure to get over 70%, possibly 80%, before the next phase.

SAVE once the cure hits 70%. At 80%, evolve all lethal symptoms minus coma. Wait it out a bit, until you have a cure above 70% and only 4 million living humans. Stop the timer and devolve all 3 Reshuffle abilities. Go back to the game, start the timer again, and make sure the cure jumps to 100%. If you've done it right, you should get a pop-up that says the cure is being distributed.

If luck is on your side, you'll unlock:

Film Fanatic

Recreate the setting of the Dawn of the Planet of the Apes film

Film Fanatic
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Start up another game on casual with:

ATP Boost
Ion Surge
Teracyte
Extremophile
Together Strong

Start in Saudi Arabia and evolve:

Simian Neuro-Genesis
Ape Colonies
Social Cohesion
Cognitive Shift
Education
Ape Rampage
Organized Travel

Place a colony in Saudi Arabia right away once you have Education and if your plague has spread. Now your focus in spreading the plague as fast as you can. Evolve the following while making sure your timeline doesn't pass 11 months from your start date to be safe and keep de-evolving all mutations but Neuro-Enhancement I and II:

Air I
Water I
Drug Resistance I
Cold I
Air II
Water II

By this point you should be close to 11 months from the start date. If you are low on DNA let it pile up now so you can prepare for the end of the month. If you have excess, evolve a few travel upgrades or Air/Water II. Bird I and Insect I don't hurt either. Keep in mind you need around 35 to 40 DNA to evolve all the way to Total Brian Death. Once you hit about 10 days before a year from the start date, evolve Neuro-Enhancement I, II, III, and Total Brian Death. Let it run for about 3-4 days in game time and then DE-EVOLVE Total Brain Death and Neuro-Enhancement III.

If you did this quick enough, not too many people died due to the upgrade and the cure should only just be starting. Evolve:

Air/Water II
Bird I
Insect I
Drug Resistance II
Cold Resistance II

Keep adding another 2 ape colonies to help speed up your DNA collection. Start upgrading your Ape Rampage attacks (Primal Hunt & Weapon Creation) and all your movement abilities (Logistics, Seafaring, & Horseback Riding).

Keep an eye on labs that are working on the cure and Rampage them to destroy the labs. Feel free to put some DNA points into Genetic Hardening I and II to help slow down the cure. Avoid drones and wait until you get the pop that says there is no healthy people left in the world. Now just upgrade Total Brain Death again and any other lethal symptom you can get your hands on while hunting down labs. Once the population dies off, pop goes:

No Idea

Evolve 'Total Brain Death' in the first year and win

No Idea
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Start another casual game with any genes, evolving the following symptoms:

Photophobia
Subconjunctival Bleed
Subconjunctival Hemorrhage
Neuro-Enhancement I, II, and III
Total Brain Death
Bat I and II
Blood I and II

You should soon get a combo pop-up and unlock:

Not Necroa

Discover the Zombie Panic Combo

Not Necroa
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Start up another casual game with any genes and evolve:

Simian Neuro-Genesis
Organised Travel
Logistics
Horseback Riding
Ape Rampage
Primal Hunt
Weapon Creation

This will earn you:

Red Ape Redemption

Discover the Red Ape Redemption Combo

Red Ape Redemption
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With that done, you should have finished up with the Simian Flu. Congratulations! Time to move onto Shadow Plague...

Shadow Plague is the latest update to the game, introducing a new pathogen and a few Brexit/President Trump themed news tickers in the base game pathogens. Shadow Plague is very easy, it plays similarly to Simian Flu in the sense that you can build colonies and move infection vectors around in order to spread your disease, but it's much easier to accumulate tons of DNA in Shadow Plague.

First up, you need to do the usual process of unlocking all the Vampire-related genes by unlocking them from a save. In order to get that save, first load up game on Casual difficulty with the following genes:

Teracyte

Extremophile

Start your vampire in China and evolve the following genes;

Shadow Blessing

Blood Gift

Dark Cloud

Shadow Trail

Corrupted Air

Allow the game to continue. Within a few seconds, you should have a massive burst of infected countries to massively bolster the DNA you have in-hand. As soon as you can, unlock;

Therianthropy

This gives your vampire the ability to fly around the map, at a limited distance for now. Continue the game and wait for the message “Vampire feeding attracts attention in China”, then fly to India. when you start your first flight, you'll pop;

Batmobile

Transform vampire into a bat and fly somewhere

Batmobile
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Evolve the following when you have the points;

Night Wraith

Lair

Use lair to build a lair for yourself in India.

After your first lair is constructed, you'll earn;

Home Sweet Home

Set up a vampire lair

Home Sweet Home
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Once that is constructed, fly your vampire over to Saudi Arabia. Wait here until you’ve infected around 80% of the country, the fly on to Central Africa. Build a second lair here.

Use your DNA points to unlock;

Travel Speed 1

Travel Speed 2

Then fly to the western-most point of West Africa or to the most southernly point of Morocco, then from here to a northern point in Brazil (near the border to Colombia). Build your third lair here and wait for a few seconds until Argentina, Peru and Colombia are infected.

Fly to the USA (land on the East Coast) and wait until Canada and Mexico become infected (only takes a few seconds usually). From here, you’ll want fly to another series of countries, then wait for a few seconds in each country and infect the local countries, in the following order;

Greenland

Iceland

Sweden

UK

Spain

Germany

Ukraine

Turkey

While you’re batting about all over Scandinavia and Europe, you should be able to collect DNA from your lairs, orange DNA bubbles and infections. When you have the DNA, evolve the following;

Shadow Portal

Nocturnal

Anaemia

Pallor

Weeping Sores

Hyperdontia

Jugular Bite

Shadow Slaves

Once you land in Turkey, make another flight, via India, down into Oceania, landing in Australia first. Create your fourth lair here. Fly to the remaining countries around here to infect them (New Zealand, Philippines, New Guinea and Indonesia). You should also have enough DNA to evolve the following during your flights;

Blood Rage

Use cn_LS to activate your Blood Rage ability, which will give you a solid amount of DNA. This gives you:

Heart of Darkness

Send your vampire into a Blood Rage

Heart of Darkness
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Around now, you’ll probably get pop-ups stating that “Blood Cult leader has been tracked to (Insert country here)” and “Templar Industries alerts world to vampire threat” or something along those lines. Around here, my Vampire was spotted by humanity, which popped;

Twilight Lied

Let Humanity discover your vampire

Twilight Lied
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You’ll likely start seeing Templar Labs appear around the world, either fortresses that are being set up (that appear as a grey chemical flask) or that are fully set up (blue chemical flasks)

When the message “Templar Industries deems (your disease) a threat”, evolve;

Vampiric Awakening

Keep collecting DNA, while a good portion those infected die off in the hunt for another vampire. When you have the required DNA, evolve;

Lair Healing 1

Adrenal Surge

Keep collecting DNA. When you see the message “Templar Industries activate military protocols”, you’ll see countries with a little castle icon in them. These countries will become your main targets. To destroy them, fly to them and then use your Blood Rage ability in that country. Your vampire will go into combat with Templar Industries. Your health and their health are shown in the icons on the map (you’ll see the colour start to deplete from them). If you vampire gets too low, fly back to your nearest lair to start healing. You should be able to take out the fortresses as they pop up. Once the fortress is destroyed, fly back to any of your lairs to heal up.

When you destroy a Templar base, you'll pop;

Van Helsing's Doom

Destroy a Templar fort

Van Helsing's Doom
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As you earn more DNA, evolve the following as soon as you are able;

Lair Healing 2

Dark Infiltration

Shadow Blades

Demonic Fury

Around this time, you’ll also get a second vampire indicated by the message “New vampire created in (random country). Control this vampire and make them fly to any of your lairs to let them heal to full strength. When your vampire(s) are fully healed, fly them to each of the Templar countries and start destroying them with Blood Rage, then fly them back to a lair to let them heal.

During this fighting period, drones will also start targeting lairs. To stop this, send one vampire back to the lair the drone is targeting (it will start circling a country) and then use Blood Rage to destroy it. When the last Templar country is destroyed, you’ll see the notification “Templar forces eradicated”.

Now all that remains is to target the countries with labs that are trying to cure your disease. Fly your vampires to them and destroy them with Blood Rage. After destroying them all, send your vampires around to the remaining living countries and use Blood Rage to wipe out the remaining living people.

Remember, before you kill off everyone, make a save when the death of everyone on Earth is inevitable. Use this save to unlock all the vampire genes to be used later.

Head into the deep end now and start by loading up the game on Mega Brutal difficulty. Start with the following genes:

Harvester
Budget Bat
Aerocyte
Extremophile
Witch Doctor

Place your vampire in Greenland and evolve the following vampire traits:

Theriantrophy
Blood Rage

As soon as you're able to, evolve:

Dark Ritual I and II
Adrenal Surge

Continue to feed in Greenland until everyone in the country is dead and you begin to starve. Use your bat ability to now fly over to Iceland.

In Iceland, go back into Blood Rage. This time evolve:

Dark Infiltration
Shadow Blades
Demonic Fury

Stay in Iceland and eradicate it entirely, immediately flying to the nearest country with a Templar base immediately after. Use your Blood Rage on the country to destroy the Templar base.

Now go through and destroy more bases, saving before each one. Your health bar can be seen by zooming in on whichever country you are in, if the red portion in the box above the vampire is low, retreat from the country with the base and Blood Rage somewhere else to heal. As soon as you can, evolve:

Travel Speed I and II

This will allow you to travel faster and farther, making it easy to take out the remaining bases. If you ever need to retreat mid-battle against Templars, that's fine. Just heal up in a nearby country, then come back and attack before the Templar bases regain strength. If you get a message about your vampire being weak, but the base you're fighting is also low on health, try to tough it out. If you die, reload the save. If you destroy the base, you'll earn:

Luck of the Devil

Destroy a Templar fort with near death vampire

Luck of the Devil
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Now save again and fly to the nearest highly populated country and perform a Blood Rage. With the threat of Templars gone, you're free to consume as you please. Accumulate 550 DNA before saving again and proceeding on by evolving:

Lair
Shadow Portal

You'll want to strategically place these lairs, so travel to Australia, China, Ukraine, Central Africa, Brazil, and America and place a lair down. This will allow you to teleport instantaneously between any of them at will, making the next step much easier.

Placing multiple portals may grant you the Hellmouth Combo at some point, giving you:

Welcome to Hellmouth

Discover the Welcome to Hellmouth Combo

Welcome to Hellmouth
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Stay in America and feed until you get back to 550 DNA before moving to Egypt via your African lair. Once there, evolve:

Shadow Blessing
Blood Gift
Dark Cloud
Shadow Trail
Corrupted Air
Cold/Heat/Antibiotic Tolerance
Air I and II
Water I and II
Extreme Bioaerosal
Fomites I and II
Droplets I and II
Blood I and II
Zoonotic Shift
Bat I, II, and III
Wolf I and II
Dog I and II

This massive evolution allows you to infect a country thoroughly simply by traveling to it, so teleport between your lairs and fly out to surrounding islands that'd otherwise be a pain to infect. The cure will soon be underway, so travel to each lab and Blood Rage in the country. Save up your DNA and travel around, infecting and Blood Raging until the cure gets up to 70% or so. SAVE HERE. Start off by evolving:

Dark Pustules
Hypersensitivity
Malignant Pigmentation
Latent Adaptation
Pallor
Weeping Sores
Hyperdontia
Jugular Bite
Shadow Slaves

The creation of Shadow Slaves unlocks:

Blood Pets

Create slaves for your vampire

Blood Pets
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This will also make 2 combos available, unlocking:

Plague Dogs

Discover the Plague Dogs Combo

Plague Dogs
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Evil is a point of view

Discover the Evil is a point of view Combo

Evil is a point of view
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After a very short amount of time, you will enslave humanity and unlock:

Vampire Master

Beat Shadow Plague on mega-brutal difficulty

Vampire Master
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Load your previous save and evolve:

Dark Pustules
Hypersensitivity
Malignant Pigmentation
Latent Adaptation
Pallor
Weeping Sores
Hyperdontia
Jugular Bite
Steroidal Boost
Pheromone Secretion
Anabolic Boost
Hypocoagulability
Internal Hemorrhaging
Hemorrhagic Shock
Cranial Elephantitis
Autophagia
Vampiric Awakening

Some of these may take time, depending on how much DNA you've accumulated. This gives you the ability to unlock the following combos:

Uphill Ice Skating

Discover the Uphill Ice Skating Combo

Uphill Ice Skating
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Purity of the Chosen

Create a new vampire

Purity of the Chosen
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Essential Vitamins

Discover the Essential Vitamins Combo

Essential Vitamins
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If an infected host is chosen properly to create a new vampire, it unlocks:

Purity of the Chosen

Create a new vampire

Purity of the Chosen
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This will kill very quickly, so make sure you have a large portion of the globe infected before the evolution. Now go around and infect every country, destroy every lab, and Blood Rage to earn more DNA. If you succeed in destroying the world without evolving Shadow Slaves, you'll unlock:

Sadomasicist

Beat Shadow Plague with no Shadow Slaves

Sadomasicist
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Next, we will work on combos. If you run out of DNA and need to reload this save, feel free to do so at any point. Now load your save again and evolve:

Lair Healing I and II

This, in conjunction with your Bat transmissions, gives you:

Bat Cave

Discover the Bat Cave Combo

Bat Cave
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Now evolve:

Nocturnal
Steroidal Boost
Pheremone Secretion
Photophobia
Hyperdontia
Jugular Bite
Shadow Slaves
Muscular Hypotrophy
Masticatory Tension

This will grant you the ability to get the Carpe Jugulum combo and:

Carpe Jugulum

Discover the Carpe Jugulum Combo

Carpe Jugulum
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Evolve Night Wraith, which is the last ingredient needed in Silent but Deadly and Dark Night for:

Silent but Deadly

Discover the Silent but Deadly Combo

Silent but Deadly
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Dark Night

Discover the Dark Night Combo

Dark Night
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Next up, evolve:

Nocturnal
Anemia
Pallor
Weeping Sores
Photophobia
Hyperdontia
Jugular Bite
Shadow Slaves
Dermal Calcification

This will allow you to get:

Diamond Skin

Discover the Diamond Skin Combo

Diamond Skin
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From here, evolve Cranial Elephantitis and Malignant Pigmentation for:

Blood Trumps All

Discover the Blood Trumps All Combo

Blood Trumps All
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Now evolve Muscular Hypotrophy and Masticatory Tension for yet another combo and:

Dentist's Dream

Discover the Dentist's Dream Combo

Dentist's Dream
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Now evolve Anabolic Boost for this next combo:

Mr. Universe

Discover the Mr. Universe Combo

Mr. Universe
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That's it for combos! Now it's time to start a new game on Normal to work on an odd achievement, before getting into the tedious news items. Start in America and evolve Blood Rage, Lair and Theriantrophy immediately. Plant a lair before using Blood Rage and very carefully watch the number of people killed. You need to reach exactly 123 people killed in America. If you go over, restart. Once you hit 123 precisely, fly into Canada or Mexico and wait for:

Count Countula

Carefully count your vampire's feeds

Count Countula
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The news items come up randomly and in any order. The Shadow Pool event begins in Turkey, Stonehenge in the UK, and Dracula in Central Europe. If you want to force, for example, the Dracula event, you'll want to kill people in the UK and Turkey whilst staying out of Central Europe. Begin anywhere you like and travel from country to country quickly, before you attract the attention of the authorities or Templar forces. If you see something along the lines of "Blood cult blamed in (country) for killings", it's time to fly away. So pick in any country aside from the aforementioned three, evolve Night Wraith and Theriantrophy, then begin waiting for the pop-up. Restart or reload a save if nothing appears before 10 months have elapsed.

This can come up in any order, so feel free to jump around if you get a different order. I personally got Stonehenge first, which is initiated by a pop-up stating that an ancient chamber was discovered in Stonehenge. Shortly thereafter, you'll get a pop-up about a mutated skeleton being found in the passage. SAVE HERE. Now fly over to the UK and evolve your plague, being sure to evolve Steroidal Boost and Anabolic Boost. This will infect the UK, and when the tourists replace the stones you'll unlock:

Making Amends

Help tourists repair the damage to Stonehenge

Making Amends
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Now load up your save and evolve whatever symptoms you want, making sure to also evolve Water I and II as well as Air I and II. Once your disease is known to be infecting people, you'll get another message about the Stonehenge skeletons being infected with your disease. Save here once again, then fly into the UK and evolve Extreme Bioaerosal. Your next notification will be about the skeleton infecting the scientists, giving you:

Greyscale

Infect Stonehenge explorers

Greyscale
3 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Load up your last save and continue to evolve your disease, as well as doing some Blood Rage. Destroy any labs to slow the cure and battle any Templar forces, WITHOUT destroying them entirely. Eventually, you'll see a few news items relating to Stonehenge. What matters most is the pop-up indicating that the Templars plan on nuking Stonehenge since it is a high risk location. Once you see that, return to the UK and evolve both paths of Dark Ritual and whatever you can afford in Blood Rage before using it in the UK. This will give you a huge DNA boost as well as:

Power Overwhelming

Consume the bones at Stonehenge

Power Overwhelming
3 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

That's the UK done, so for your next game start there. My next pop-up related to the Dracula story, which is about how a historian found an ancient map of Romania. Evolve Shadow Blessing and fly around until you see a pop-up stating that the historian states Dracula was real. SAVE HERE. Fly into Central Europe and evolve Dark Pustules, which will result in a humorous destruction of the map and:

Pus Explosion

Oooze pus everywhere!

Pus Explosion
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Load up your save and fly around, waiting for another pop-up stating that Dracula was real. Save here again, then evolve Zoonotic Shift and both Wolf transmissions before flying into Central Europe. The historian will be devoured by wolves and you'll unlock:

Wolf Pack

Hunt down historian searching for Dracula's tomb

Wolf Pack
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Load up your last save and a ton of news stories will pop up about Dracula, just wait until you see the one that states "Historian spots note about Dracula's return". Evolve Blood Rage, Lair, both sets of Lair Healing and fly into Central Europe. Perform a Blood Rage to bring Dracula back to life for:

I am your Father

Resurrect Count Dracula

I am your Father
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Now for the final news item. so start up another game and start in the UK. After killing someone there, fly to Central Europe and kill there. Now fly about until you see a pop-up about a cave system discovered in Turkey. Evolve Shadow Blessing and fly around until you get another pop-up about the Shadow Pool being discovered. SAVE HERE. Evolve Blood Rage and use it in Turkey, killing the cavers and giving you:

Rock Bottom

Consume the cavers exploring the Shadow Pool

Rock Bottom
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Load your save and continue flying around, leaving Turkey alone. until you get a pop-up about human remains being found near the Shadow Pool. Save again, then evolve Zoonotic Shift as well as all 3 Bat transmissions. Go into Turkey to infect it to let the bats kill the cavers for:

Chiroptophobia

Drive out cavers before sampling the Shadow Pool

Chiroptophobia
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Load your save and fly around until you get a news item about the Shadow Pool organisms being billions of years old. Use Blood Rage and evolve whatever symptom path you want up to Shadow Slaves. Infect Turkey and make sure it's fully infected by the time you are discovered by Templars. You'll get a final pop-up about the first vampire originating in the Shadow Pool, then quickly evolve Shadow Slaves and Muscular Hypertrophy. The Templars will be drowned in the pool by the Shadow Slaves, granting you:

Watery Grave

Drown Templar scientists in the Shadow Pool

Watery Grave
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That's the end of the Shadow Plague update!

Before we begin with the scenarios proper, time to utilize the cheatmodes we unlocked by beating every virus on Mega-Brutal. Start a new game up and activate the Shuffle Strain cheat, then choose Neurax Worm on Mega-Brutal using the genes:

ATP Boost
Base Hydrolysis
Native Biome
Extremophile
Trans-Stasis

Unfortunately, with shuffle strain, it's impossible to say what order to evolve in. Your main goals are to get a few transmissions, Trojan Planes I for sure, and Transcendence. With these evolved, focus on other transmissions and genetic reshuffles. Save once you've nearly wiped out all life. Once the world is destroyed, load up that save and let everyone die 4 more times and after this you'll unlock:

Normal Shuffle

Win 5 times in a row on normal difficulty with the shuffle strain enabled

Normal Shuffle
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Mega-Brutal Shuffle

Win 5 times in a row on mega-brutal difficulty with the shuffle strain enabled

Mega-Brutal Shuffle
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Fire up another game, this time swap out the shuffle strain for the Lucky-Dip strain in the cheats menu. Again, Neurax on Mega-Brutal with:

ATP Boost
Base Hydrolysis
Native Biome
Extremophile
Trans-Stasis

Since you have stuff evolved, you could be starting off strong. Follow this path:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Once everyone is infected, you will unlock:

Bingo!

Win 5 times in a row on normal difficulty with the lucky dip strain enabled

Bingo!
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.Stackable - These achievements can be unlocked at the same time as, or in the course of, earning its more difficult or less difficult counterpart.

Lottery Winner!

Win 5 times in a row on mega brutal difficulty with the lucky dip strain enabled

Lottery Winner!
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Now, let's get into the scenarios. Scenarios are situations in the game that have some pre-determined qualities, whether it's the starting country, disease, symptoms, or all of the above. For these achievements, you have to score a 3 Biohazard rating on these scenarios, which requires a certain score. Score is determined by cure percentage and time completed. From the menu you'll want to go into official scenarios, starting off with Black Death. Black Death starts you off as a bacteria with some new symptoms and transmissions. On casual, use the genes:

Catalytic Switch
Suppression
Genetic Mimic
Extremophile
Sympto-Stasis

Start in China and evolve:

Cysts
Flea II
Skin Lesions
Rodent I
Pneumonic Plague
Coughing
Sneezing
Drug Resistance I
Livestock I
Bird I
Cold Resistance I
Water I
Septic Plague
Abcesses
Nausea
Vomiting
Pulmonary Edema
Hemoptysis
Heat Resistance I
Drug Resistance II
Air I
Genetic Hardening I
Cold Resistance II
Heat Resistance II
Blood I
Diarrhea
Dysentery
Hypotension
Hemorrhagic Shock
Total Organ Failure
Hyper Sensitivity
Inflammation
Seizures
Paralysis

The key seems to be finishing in under a year with under 60% cure for maximum points. After scoring your 3 Biohazards, you'll unlock:

Complete Black Death

Score 3 biohazards with Black Death scenario

Complete Black Death
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next up is Created Equal. This time, your disease is spotted more easily, even in poor countries. Start up Neurax Worm on casual with the following genes:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold/Heat/Drug Resistance I and II

Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Focus on your transmissions now, evolving all of them. Take some points away to evolve your Reshuffles as you see fit. Once the world is infected and your 3 Biohazards are unlocked, you'll get:

Complete Created Equal

Score 3 biohazards with Created Equal scenario

Complete Created Equal
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Our next Scenario is Golden Age. In this one, the improved healthcare of the world makes infection harder to spread and easier to cure. We're once again using the Neurax on casual, with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Use the remaining DNA for transmissions, followed by reshuffles to maximize your score. After getting your points, you'll unlock:

Complete Golden Age

Score 3 biohazards with Golden Age scenario

Complete Golden Age
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Global Warming, so start Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

After scoring your bios, you'll unlock:

Complete Global Warming

Score 3 biohazards with Global Warming scenario

Complete Global Warming
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next, we have Ice Age. The overall global temperature has decreased, so cold resistance is gonna be used. Start up Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder
Mutative Regeneration 1 and 2
Trojan Planes 1
Cold Resistance 1 & 2

Drug Resistance 1 & 2
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Again, put your remaining points into transmissions and reshuffles to keep the cure low and infectivity high. After finishing with your 3 Bios, you'll get:

Complete Ice Age

Score 3 biohazards with Ice Age scenario

Complete Ice Age
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now, we have Mirror Earth. This is basically where everything is opposite. For example, East Africa is rich and cold while Canada is poor and hot. Same deal, Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold/Heat/Drug Resistance I and II

Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Same deal here, make use of your remaining DNA to increase infectivity and keep the cure as low as possible to score your biohazards and unlock:

Complete Mirror Earth

Score 3 biohazards with Mirror Earth scenario

Complete Mirror Earth
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The next one up is Pirate Plague. This one truly sucks. Water transmission is basically non-existent and can't really be relied upon. This is easy to overcome with Neurax, but everything else....I'm saving that for the next page. Neurax on normal with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis.

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Again, transmissions and reshuffles to keep your score up for:

Complete Pirate Plague

Score 3 biohazards in the Pirate Plague scenario

Complete Pirate Plague
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now we move onto Shut Down Everything, based on a meme created by the original Plague Inc and its sister game, Pandemic. A tough scenario, borders and ports are likely to get shut down very quickly. This is another one that requires all plagues, but for now we're doing Neurax on normal with:

ATP Boost
Darwinist
Suppression
Extremophile
Trans-Stasis

Start in India and evolve:

Eggs I and II
Concertia Locomotion

Uldolatery Locomotion
Genetic Swap
Rodent I
Insect I
Bird I
Air/Water I
Air II and III
Mutative Regeneration I and II
Trojan Planes I
Insect II
Bird II
Rodent II
Water II and III
Trojan Planes II and III
Cold Resistance I
Trojan Roamers I
Drug Resistance I and II
Trojan Roamers II
Cold Resistance II
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Transcendence

After this, you'll get:

Complete Shut Down Everything

Score 3 biohazards in the Shut Down Everything scenario

Complete Shut Down Everything
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The next one up is Smallpox, where you are given some smallpox to work with. Use the following genes:

ATP Boost
Darwinist
Aquacyte
Hydrophile
Trans-Stasis

Start in India and evolve:

Insect I
Fomites I
Vaccine Shield
Water I
Air I
Water II
Droplets II and III
Air II
Fomites II
Extreme Bioaerosol
Insect II
Cold Resistance I
Drug Resistance I
Cold Resistance II
Drug Resistance II
EJ2 Vaccine Shield
Livestock I and II
Genetic Hardening I
Corneal Ulceration
Genetic Hardening II
EJ7 Vaccine Shield
Blood I and II
Extreme Hematophagy
Genetic Reshuffle I
Necrosis
Coma
Genetic Reshuffle II and III

Once you win, you will be awarded:

Complete Smallpox

Score 3 biohazards with Smallpox scenario

Complete Smallpox
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Sovereign Default is next, in this scenario most countries are easier to infect and harder to spot your disease in, making things easier. Use the Neurax Worm on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Now use your DNA on, you guessed it, transmissions and reshuffles. After getting this one done, you'll unlock:

Complete Sovereign Default

Score 3 biohazards with Sovereign Default scenario

Complete Sovereign Default
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Next is Swine Flu, you're given a virus here by default. Use the genes:

ATP Boost
Darwinist
Aquacyte
Hydrophile
Trans-Stasis

Start your disease in India and evolve:

Droplets II
Nausea
Rash
Swine II
Livestock I
Water I
Air I
Water II
Livestock II
Air II
Extreme Bioaerosol
Blood I and II
Cold Resistance I
Drug Resistance I
Cold Resistance II
Drug Resistance II
Bird I and II
Extreme Zoonosis
Historic Reassortment
Genetic Hardening I and II
Vomiting
Hyper Sensitivity
Diarrhea
Inflammation
Insomnia
Paranoia
Fatigue
Epistaxis
Hemoptysis
Pulmonary Hemorrhage

Finish up with your reshuffles to score your 3 bios and:

Complete Swine Flu

Score 3 biohazards with Swine Flu scenario

Complete Swine Flu
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Volcanic Ash is annoying, very similar to Pirate Plague. Only this time, air transmission is much less likely. Start on normal with Neurax and:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Use your Reshuffles to maximize your score and finish for:

Complete Volcanic Ash

Score 3 biohazards in the Volcanic Ash scenario

Complete Volcanic Ash
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Who Cares? is an interesting one. Poorer countries are less likely to identify and treat diseases so you can run rampant. As usual, choose Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

You know the deal, transmissions and reshuffles until a win:

Complete Who Cares

Score 3 biohazards with Who Cares scenario

Complete Who Cares
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Xenophobia is an interesting one, in which land borders start out more difficult to cross. This can easily be overcome with Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Heat/Cold/Drug Resistance I and II

Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Transmissions and reshuffles until:

Complete Xenophobia

Score 3 biohazards with Xenophobia scenario

Complete Xenophobia
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Unknown Origin is interesting, as you will start in a random country. Go with Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

This gets you:

Complete Unknown Origin

Score 3 biohazards with Unknown Origin scenario

Complete Unknown Origin
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now we finally get to switch things up a bit with Nipah Virus. There are some other miscellaneous achievements to do here, so let's start with those. Start it on casual with:

Metabolic Hijack
Genetic Mimic
Aquacyte
Extremophile
Translesion

Start anywhere and evolve:

Hendra
Horse I
Horse II

Devolve anything that mutates and await a pop-up about Kim Shardakian buying a new pugapoo. Now only evolve:

Dog I
Drug Resistance I
Gene Hardening I
Cold Resistance I

Wait for a high infection rate before evolving lethal systems, using your reshuffles if the cure gets too high. Devolve Horse I and wait for the pop-up indicating that you killed Kim Shardakian's dog for:

Call PETA

Make a celebrity cry

Call PETA
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Do Nipah again on casual with:

ATP Boost
Creationist
Aquacyte
Extremophile
Ionised Helix

Start anywhere and evolve:

Hendra Traits
Horse I and II
Dog I
Cold Resistance I and II
Heat Resistance I
Drug Resistance I
Genetic Hardening I and II

At this point, SAVE. Wait for the pop-up "Lude Jaw claims Nipah cure". If the popup doesn't appear before 100% infection, reload your save. Evolve:

Encephalitic Shift
Headache
Nuchal Rigidity
Fever
Photophobia
Blurred Vision
Hallucinations
Drowsiness
Confusion
Memory Loss

SAVE again and wait for the pop-up saying "Lude Jaw triggers infection in (country name)" for:

Who needs Science

Show the world how useful homeopathy is

Who needs Science
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start up another Nipah run on casual with:

ATP Boost
Aquacyte
Trans-Stasis
Creationist
Extremophile

Start anywhere and devolve anything that deviates from this path:

Bat II
Swine I and II
Nausea
Vomiting
Photophobia
Drowsiness
Dysphagia
Drug Resistance I and II
Cold Resistance I
Heat Resistance I
Headache
Nuchal Rigidity
Fever

Now, stop devolving and just wait for a pop-up about a film being announced about your plague. Evolve Confusion and Memory Loss as soon as you see this, and wait until another pop-up about the film failing for:

Contagion Cancelled

Prevent a film about your plague being made

Contagion Cancelled
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start over again on casual with Nipah with:

ATP Boost
Darwinist
Aquacyte
Hydrophile
Trans-Stasis

Start in India and evolve:

Bat II
Swine I
Nausea
Swine II
Bat III
Bat IV
Respiratory Shift
Vomiting

Pulmonary Edema

Hemoptysis
Hendra Traits
Cedar Traits
Fomites I and II
Water I and II
Drug Resistance I and II
Pulmonary Hemorrhage
Respiratory Failure
Air I and II
Cold Resistance I and II
Heat Resistance I and II
Environmental Hardening
Encaphalitic Shift

Keep the cure low and introduce some more lethality until completion. This will get you:

Complete Nipah Virus

Score 3 biohazards with Nipah Virus scenario

Complete Nipah Virus
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Frozen Virus is next, which contains another miscellaneous achievement. Start off on casual with:

ATP Boost
Darwinist
Aquacyte
Extrempohile
Patho-Stasis

Evolve:

DNA Repair I
Edentulism
Amoeba II
Livestock I
Bird I
Insect I
Amoeba III
Livestock II
Bird II
Insect II
DNA Repair II, III, IV, V

Full DNA repair
Drug resistance I and II
Heat resistance I, II, III
Carnivorous Denticulation
Bone Dysplasia
Cranial Elephantitis
Neanderthal Regression

After that last symptom, you'll unlock:

Who needs brains

Take humanity back to the stone age

Who needs brains
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Complete Frozen Virus

Score 3 biohazards with Frozen Virus scenario

Complete Frozen Virus
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now, it's Artificial Organs. There is another achievement tied to this as well, so pick Prion on casual with:

Metabolic Hijack
Genetic Mimic
Native Biome
Extremophile
Sympto-Statis

Start in India and evolve:

Air/Water I
Nausea
Coughing
Rash
Insomnia
Cysts
Anemia
Vomiting
Sweating
Hyper Sensitivity
Abscesses
Inflammation
Diarrhea
Skin Lesions
Tumors
Internal Hemorrhaging

Now when the pop up "Artifical Organs to Save Lives" comes on screen, SAVE.

Paranoia
Cold Resistance I
Drug Resistance I
Cold Resistance II
Neutral Atrophy I, II, III
Genetic Hardening I and II

Wait for the pop-up about people ripping out their organs and:

I never asked for this

Feel the negative side of artificial organs

I never asked for this
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start up another AO run, choosing Bacteria on casual with:

ATP Boost
Genetic Mimic
Teracyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Coughing

Rash
Sneezing
Sweating
Skin Lesions
Water/Air I and II
Extreme Bio Aerosol
Drug/Cold/Heat Resistance I and II
Environmental Hardening
Necrosis
Insomnia
Paranoia
Seizures
Insanity
Cysts
Hyper Sensitivity
Paralysis
Coma

Wait for everyone to be infected before evolving:

Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging
Systemic Infection

This will earn you:

Complete Artificial Organs

Score 3 biohazards with Artificial Organs scenario

Complete Artificial Organs
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Santa's Little Helper is next, this one is easy as you are automatically given the Neurax Worm. Use any genes with ATP Boost and start anywhere before evolving:

Festive Tendrils
Sloth
Gluttony
Jealousy
Indulgence
Partying
Intoxication

This combo grants you:

On The Naughty List

Put humanity on Santa's naughty list

On The Naughty List
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Now, unlock all of the plane abilities on both sides, the final three are Red Nose Guide, Red Suited Pilot and Digital Elf. This gets you:

Ultimate Christmas

Discover the Ultimate Christmas Combo

Ultimate Christmas
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start up another Santa's Little Helper scenario on casual with:

ATP Boost
Genetic Mimic
Aerocyte
Hydrophile
Trans-Stasis

Start your plague in Saudi Arabia and evolve:

Cracker Cocoon
Emotive Radar
Santa's Little Neurax Worm
Festive Tendrils
Digital Elf
Digital Herald
Digital Angel
Solar Perfume I and II
Eggs-Nog
Sunny Side Up
Snowballs I and II
Fair-Weather Friend
Glow Worms
Snow Worm
Wellington Worm
Wild Side
Stocking Filler
Radio Worm
Gold Digger
Memory Lane
Laughter
Excitement
Joy
Indulgence
Partying

This will grant you:

Complete Santa's Little Helper

Score 3 biohazards in the Santa's Little Helper scenario

Complete Santa's Little Helper
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Last one, finally, is Teleportation. Start on casual with bacteria and:

ATP Boost
Aerocyte
Trans-Stasis
Genetic Mimic
Extremophile

Start in Saudi Arabia and evolve:

Air 1 & 2
Drug Resistance 1
Bacterial Resilience 1, 2, & 3
Drug Resistance 2
Water 1 & 2
Cold Resistance 1 & 2
Extreme Bioaerosol

At some point, maybe while saving DNA to evolve these, or afterwards.. you'll get a pop up saying people are rushing to buy teleportation tickets to safe countries. After a little while longer, whichever safe country they teleported to should become infected and you'll get another pop-up saying 'Portal attempt in *country* failure' for:

GLaDOS Says Hi

Make a teleport attempt end in tragedy

GLaDOS Says Hi
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Fire it up with Neurax on casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II

Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Reshuffle your way to victory for:

Complete Teleportation

Score 3 biohazards in the Teleportation scenario

Complete Teleportation
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Yeah that kinda took an eternity. Luckily, the last thing we need to focus on consists of doing the 3 hardest scenarios repeatedly. Joy oh joy.

....or maybe not. The Royal Update that came out in January 2019 added a number of new scenarios, one of which I personally found to be the hardest to get a good score on. Start with Where is Everyone? on casual as Neurax Worm with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II
Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

Then use reshuffles until transcendence is achieved, you should get 3 biohazards easily for:

Complete Where is Everyone?

Score 3 biohazards in the Where is Everyone? scenario

Complete Where is Everyone?
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Flight Club is up next, a really easy scenario made even easier by Trojan Planes. Load it up on Neurax Worm casual with:

Metabolic Jump
Genetic Mimic
Native Biome
Extremophile
Trans-Stasis

Start in India and evolve:

Genetic Swap
Corpse Feeder I and II
Mutative Regeneration I and II
Trojan Planes I
Cold Resistance I and II
Drug Resistance I and II
Neural Breach
Cerebral Tendrils
Frontal Mesh
Immaturity
Mania
Obsession
Devotion
Adoration
Transcendence

End with reshuffles once again, wrap up this scenario and earn:

Complete Flight Club

Score 3 biohazards in the Flight Club scenario

Complete Flight Club
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Mad Cow Disease is next, and is honestly really tough due to its inconsistency. You need a score of 65,000 and you'll often find yourself scoring between 60-64K. Speed is the key, so if your islands aren't infected with all people sick by 10 months it's probably a good idea to restart. You'll be forced to use Prion, start on casual with:

ATP Boost
Genetic Mimic
Native Biome
Extremophile
Sympto-Stasis

Start in Saudi Arabia and evolve the following as soon as you get the points:

Heat Resistance 1
Hermetic Resilience
Frozen Resilience
Preservative Storage Resilience

Human Cross-Infection
Coughing
Pulmonary Edema
Coma
Cold Resistance 1
Mania
Delirium
Insanity
Cannibalism
Systemic Infection
Necrosis
Total Organ Failure
Ataxia
Blindness
Paralysis
Acute Encephalitis
Cold Resistance 2
Genetic Hardening 1
Pork
Fish

After infecting the fish you have a good chance of creating a "sushi crisis" once Japan is infected. Once you do you'll unlock:

Sushi Crisis

Start a Sushi Crisis in Japan

Sushi Crisis
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.


Abscesses
Pneumonia
Hallucinations
Seizures
Inflammation
Genetic Hardening 2
Plant Dissemination
Potato
Avocado

Now use reshuffles, you'll want to make sure you keep the cure rate lower than 15% and finish before the 400 day mark. If you score over 65K you will unlock:

Complete Mad Cow Disease

Score 3 biohazards in the Mad Cow Disease scenario

Complete Mad Cow Disease
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Last up we have Science Denial, which unfortunately doesn't allow the Neurax Worm. Choose Bacteria on Casual instead, using:

ATP Boost
Genetic Mimic
Teracyte
Extremophile
Sympto-Stasis

Start in China and evolve:

Coughing

Rash
Sneezing
Sweating
Skin Lesions
Water/Air I and II
Extreme Bio Aerosol
Drug/Cold/Heat Resistance I and II
Environmental Hardening
Necrosis
Insomnia
Paranoia
Seizures
Insanity
Cysts
Hyper Sensitivity
Paralysis
Coma

Wait for everyone to be infected, and make a SAVE once there's a high rate. Continue on and evolve:

Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging
Systemic Infection

This will easily complete the scenario and unlock:

Complete Science Denial

Score 3 biohazards in the Science Denial scenario

Complete Science Denial
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

Now load your save and wait for the cure, devolve Coma and any Genetic Hardening symptoms. Once the cure reaches 100% a group of protesters will destroy it and you'll get:

The Cure Is A Lie

Inspire an anti-cure protest

The Cure Is A Lie
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The last new scenario is Ultimate Board Games, which is wildly different from anything else you've played before. In this instance you're creating a board game of some kind and infecting people with "hype", and "killing" them once they purchase the game. It doesn't seem feasible to sell a copy to everyone in the world since you have a 2 year deadline, but you normally succeed once you sell 20 million copies. You don't choose any abilities or pathogen types to begin with so just begin playing on casual.

We'll be starting off going for an easy victory with 3 biohazards, so start off first in the United States and look at the game design options you have. Under themes, select

Educational
Murder/Mystery
Horror
Strategy

Mechanics:

Co-operate Play
Player Elimination
Area Control
Press Your Luck

Components:

Dice
Miniatures
Tokens

Player Number:

2 Players
4+ Players

Start production of the game at this point, then evolve the following:

Videogame IP
Launch Kickstarter
Community Feedback
Film/TV Show IP
Advertise Online
Toy Line IP
Manufacture in United States
Community Outreach
Official Website
Begin Manufacturing
Begin to Sell Your Game

This opens up the "Distribution" tab, now you can evolve:

Launch Companion App
Direct Sales
Sell on Amazon
Sell on eBay
Local Game Stores
Super Fan Sendout 1
Durable Packaging 1

Now just wait out the remaining time. If your deadline hits with over 200 million sales and there still being interest, you'll win the scenario and likely get 3 biohazards for:

Complete Ultimate Board Games

Score 3 biohazards in the Ultimate Board Games scenario

Complete Ultimate Board Games
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.

The remaining achievements are related to board game combos, which are very easy and quick since they're guaranteed. All you have to do is select certain designs, begin production, and immediately get a pop-up stating what combo you produced. Your starting country doesn't matter, so pick anything and select:

Themes:

Adult
Economic

Mechanics:

Bluffing
Competitive Play
Hand Management
Player Elimination
Press Your Luck

Components:

Cards

Player Numbers:

Two Players
Three Players
Four+ Players

Begin production, get your combo, unlock:

Kind Of A Big Deal

Discover the Poker board game combo

Kind Of A Big Deal
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Animals
Sports

Mechanics:

Co-operative Play
Dice Rolling
Press Your Luck

Components:

Dice
Miniatures
Timers

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

A Colt Classic

Discover the Steeplechase board game combo

A Colt Classic
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Educational
Family
Party

Mechanics:

Co-operative Play
Dice Rolling
Memory

Components:

Dice
Cards
Miniatures
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Anything But Trivial

Discover the Trivial Pursuit board game combo

Anything But Trivial
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Economic
Party

Mechanics:

Competitive Play
Dice Rolling
Hand Management
Trading

Components:

Dice
Cards
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Plague-opoly

Discover the Monopoly board game combo

Plague-opoly
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Nautical
Strategy
War Game

Mechanics:

Competitive Play
Bluffing
Memory
Player Elimination
Press Your Luck

Components:

Miniatures

Player Numbers:

Two Players

Start production, get your combo, unlock:

Sinking Feelings

Discover the Battleship board game combo

Sinking Feelings
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Educational
Family

Mechanics:

Competitive Play
Hand Management

Components:

Tokens

Player Numbers:

Four+ Players

Start production, get your combo, unlock:

Spelling Out Success

Discover the Scrabble board game combo

Spelling Out Success
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Economic
Family
Humor
Party

Mechanics:

Co-operative Play
Dice Rolling
Press Your Luck
Hand Management

Components:

Dice
Cards
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Party Hard

Discover a compulsory enjoyment board game combo

Party Hard
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Strategy
War Games

Mechanics:

Competitive Play
Dice Rolling
Press Your Luck
Player Elimination
Area Control

Components:

Dice
Miniatures
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Catan You Believe It?

Discover the Settlers Of Catan board game combo

Catan You Believe It?
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Strategy
War Games

Mechanics:

Co-operative Play
Dice Rolling
Area Control
Player Elimination

Components:

Dice
Miniatures

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Taking Risks

Discover the Risk board game combo

Taking Risks
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes :

Animals
Murder/Mystery
Nautical

Mechanics:

Co-operative Play
Area Control
Memory

Components:

Cards
Miniatures

Player Numbers:

Single Player

Start production, get your combo, unlock:

Killer Combo

Discover the Cluedo/Clue board game combo

Killer Combo
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Adult
War Game
Family

Mechanics:

Co-operative Play
Trading

Components:

Timers

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Awkward!

Discover an inappropriate board game combo

Awkward!
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Educational
Medical
Strategy

Mechanics:

Co-operative Play
Dice Rolling
Hand Management
Area Control

Components:

Dice
Cards
Tokens

Player Numbers:

Single Player
Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Infecting Tabletops

Discover a very familiar board game combo

Infecting Tabletops
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Start again and evolve:

Themes:

Animals
Horror

Mechanics:

Player Elimination
Dice Rolling
Press Your Luck

Components:

Dice
Cards
Tokens

Player Numbers:

Two Players
Three Players
Four+ Players

Start production, get your combo, unlock:

Welcome To The Jungle!

Discover a cursed board game combo

Welcome To The Jungle!
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Shop - These achievements require the purchase of an item or a series of items as prerequisites from a shop.

Alright with all that said and done...NOW you can do the 3 worst scenarios repeatedly.

This part is incredibly painful. The last 3 achievements require you to beat the Volcanic Ash, Pirate Plague, and Shut Down Everything Scenarios on normal difficulty or higher while scoring 3 biohazards with every single plague type. Some of these, such as Neurax, are easy and you have already done. Others, such as Necroa and Simian Flu, are horrendously frustrating to even win with, let alone get a great score. This is the part where you have to utilize everything you've learned about the game and hope lady luck is truly on your side. With that, let's begin.

Pirate Plague

Follow this below strategy for bacteria, virus, parasite and prion. Start on normal with these genes:

Cytochrome Surge
Genetic Mimic
Aquacyte
Urbophile
Sympto-Stasis

Start in China and evolve:

Rash
Sweating
Skin Lesions
Coughing
Sneezing
Air I and II
Cold Resistance I
Drug Resistance I
Water I and II
Extreme Bioaerosol
Heat Resistance I
Cold Resistance II
Rodent I
Drug Resistance II

Devolve any lethal symptoms that mutate and SAVE once China is infected. If Philippines isn't infected within a month, reload the save. Now keep an eye on New Guinea. No boats? Load and try again.

Madagascar...
Greenland...
Caribbean...

Evolve:

Total Organ Failure
Necrosis
Hemorrhagic Shock
Internal Hemorrhaging

If you manage to beat bacteria in Pirate Plague scenario on normal within 1 hour - congratulations! Now you can move on to virus!

For fungus...

ATP Boost
Darwinist
Aquacyte
Extremophile
Patho-Stasis

Start on normal difficulty in China and evolve:

Cysts
Abscesses
Spore Burst I, II, III, IV, V, VI
Water I
Spore Eruption
Water II
Spore Burst I, II, III, IV
Air I and II
Extreme Bioaerosol
Cold Resistance I
Bird I and II
Drug Resistance I
Cold Resistance II
Drug Resistance II
Rash
Sweating
Skin Lesions
Necrosis
Heat Resistance I and II
System Infection

Once you have only a few islands left uninfected, evolve Spore Burst, V, VI and Spore Burst. Now evolve:

Hemorrhagic Shock
Coma
Total Organ Failure
Internal Hemorrhaging

Use your reshuffles to keep the cure low, as always.

For Super Sparrow, change Aquacyte to Aerocyte and evolve Air before Water.
For Mr. President, change Aquacyte to Suppression and keep an eye on the cure.

For Necroa use:

ATP Boost
Darwinist
Aerocyte
Xerophile
Spliced Activation

Start in Saudi Arabia, quickly spread upon the world using Saudi Arabia's airplanes, then grind out with Zombie Horde. Evolve:

Zoonotic Shift
Insect I
Bat I and II

SAVE your game after evolving Bat 1, load if you don't mutate Hyper Salivation in about 100 days. Evolve:

Polyphagia
Gastroenteritis
Drug Resistance I

SAVE here. If Saudi shuts airports before you infect Australia and one of the North American countries, reload your game. Save some DNA points waiting for the second mutation, load if you didn't get Cannibalism in about 200 days. Evolve:

Cytopathic Reanimation
Anaerobic Resuscitation
Enhanced Motor Control
Masticatory Tension
Anabolic Boost
Horde Instinct
Structured Travel
Dyskinetic Movement
Echopraxia
Engorged Quadriceps

SAVE here again. Time to utilize special ability Zombie Horde, thanks to Spliced Activation it only costs 2 DNA per use. Send zombies whenever you have DNA points, try to infect the world ASAP. When you are about to infect the whole world evolve:

Peptide Surge
Dermal Calcification
Cranial Elephantitis
Bone Dysplasia
Acidic Reflux
Naja Mortis
Autothysis

If you are concerned with Z-Com, evolve Horde Mentality, Horde Vocalization (and Horde Pheromones if you have enough DNA points) and send waves of zombies at Z-Com, they don't even stand a chance.

For Nano-Virus...

Change Cytochrome Surge to ATP Boost
Evolve Code Fragment Interception after Sweating
Evolve Code Segment Interception after Sneezing

You won't have to worry about the cure since you will be spreading around the world and stabilizing in four months, the cure remains below 80%. Overload as soon as you get each of the tier-one resistances. Keep in mind that Insomnia, Paranoia, Inflammation, Seizures, Insanity, Paralysis, Coma are really really cheap now.

For Bio-Weapon...

Change Cytochrome Surge to ATP Boost and Sympto-Stasis to Patho-Stasis

Evolve Gene Compression I and Nucleic Acid Neutralization I right after evolving Skin Lesions, skip Coughing and Sneezing. Evolve Deactivated Modified Genes I and Gene Compression II between Air I and II, Nucleic Acid Neutralization II after Air 2, and get coughing and sneezing. Evolve Gene Compression III, Deactivated Modified Genes II, and get Nucleic Acid Neutralization III after Rodent I. If you are killing too quickly, get Deactivated Modified Genes III. One you have a very high infection, finish it off by evolving the Annihilate Gene.

For Simian Flu use:

ATP Boost
ATP Overdose
Teracyte
Extremophile
Leadership

Start in Central Africa and evolve:

Simian Neuro-Genesis
Inter-Genus Dissemination I and II
Ape Colonies and set your first colony in Central Africa
Organised Travel

Send your colony to East Africa while infecting Sudan and set a colony in Central Africa (Close to West Africa) and another one in Sudan. Send the colony in Central Africa to West Africa after it generates DNA and set your fourth colony in Central Africa again. By this time, Saudi Arabia should be infected, evolve Logistics and send them to Russia while infecting Iraq, Iran, Central Asia, Kazakhstan, and China.

Evolve Seafaring and send a troop from Saudi Arabia to New Zealand while infecting India, Indonesia, Australia. Evolve Cognitive Shift and Education, your apes must have arrived in Russia by now. Send apes from Russia to Mexico while infecting Baltic States, Poland, Gemany, France, Caribbean, and Central America. Now send another troop to Canada while infecting Iceland and Greenland; and the last one from Morocco to Argentina while infecting Brazil and Bolivia. Set your last colony in Indonesia and evolve:

Cold Resistance I
Drug Resistance I
Photophobia
Subconjunctival Bleed
Subconjunctival Hemorrhage
Headache
Joint Pain
Hominidae Bridge
Restart if it took you more than 9 months to reach this point. Evolve:
Bird I and II
Air I
Water I
Fomites I, II, III
Bat I and II

When a Gen-Sys lab pops up, evolve Ape Rampage and destroy it. Send apes from Southeast Asia to New Guinea while infecting Phlippines, and another group from China to Japan while infecting Korea, the last one will be from U.K to Iceland. Ramp up symptoms, which I will not specify but try to get those that both increases infectivity and lethality. You'll also want to get Cold and Drug Resistance II during this process. After you get all of the 'good' symptoms, it's time for the final blow - Total Brain Death. Evolve Air and Water II, Extreme Bioaerosol afterwards, otherwise people die too quickly before they infect others in Canada. You can leave Greenland or small numbers of humans alive and healthy to end the game.

Shadow Plague

The latest addition to the game is the Shadow Plague. The main setup for is almost the same of each of these three scenarios. Shadow Plague, for all three scenarios, will require a bit of good timing. Always play on normal speed, to allow you better control over what happens. When you first land in and uninfected country, wait for your vampire to infect the first wave of people (a few thousand) and then pause the game before continuing. Plan out you journey before you continue, you'll want to land in every single uninfected country (or barely infected, under 2000 people or so for example) as efficiently as possible, and to this end use the shortest flight paths possible, and try to travel to the closest possible country.

With that being said start a new game on Normal and choose the following genes;

Brawler

Budget Bat

Aerocyte

Urbophile

Mad Scientist

Start all the way over in Canada. Once you start, evolve the following;

Shadow Blessing

Lair

Theriantropy

Blood Gift

Dark Cloud

From here, fly to the USA and place your first lair here. Then follow the following flight and evolution path;

Fly south to Mexico, Central America and then the Caribbean, remembering to pause in each country for the first wave of infections. While in the Caribbean, evolve;

Shadow Trail

Fly south again into Colombia and Peru, and here evolve;

Droplets 1

Continue around the remaining South American countries in the following order; Bolivia, Argentina and then Brazil. Once in Brazil, evolve;

Travel Speed 1

Fly east and land in West Africa, and establish your second lair here.

SAVE here.

From where you are in West Africa, you have another long string of flights. You'll want to travel in this order; Morocco, Algeria, Libya, Central Africa, Angola, Botswana, South Africa, Zimbabwe, East Africa, Madagascar, Sudan, Egypt and finally Saudi Arabia. During these flights and infections, as soon as you have enough DNA available, evolve the following;

Fomites 1

Corrupted Air

Droplets 2

Fomites 2

Shadow Portal

You'll then want to continue flying around the rest of Asia, finishing up in Russia. Take the following path, starting in Saudi Arabia. Fly to Turkey, Iraq, Iran, Kazakhstan, Central Asia, Afghanistan, Pakistan, India, S.E. Asia, China then Russia. Once you reach Russia, set up your third lair, close to the border of Europe. Finally, you'll want to fly down to Oceania and infect all the countries there. You can take the following path; Russia, Korea, Japan, Philippines, Indonesia, New Guinea, New Zealand then Australia. Set up your fourth and final lair in Australia.

From here, teleport back to your lair in Russia. From here you'll want to fly around the remaining uninfected/ barely infected countries. From Russia, fly to Finland, then Norway, Sweden, Germany, Poland, Baltic States, Ukraine, Central Europe, Balkan States, Italy, Spain, France, UK, Iceland then Greenland. You should now have every country in the world infected. During these flights into Scandinavia and Europe, as soon as you have the DNA available, evolve the following;

Nocturnal

Anaemia

Pallor

Weeping Sores

Hyperdontia

Jugular Bite

Shadow Slaves

Teleport to your lair in the USA, wait here for about 5-10 seconds, then fly up to Canada and wait there until you get enough DNA to evolve;

Blood Rage

SAVE here.

At this point, your games should have been running for around 8 months, and Templar Strongholds will have begun to appear. From here, you must fight the Templars, Destroy labs and protect your lairs. You should always, prioritise destroying labs (without the virus in the game, your vampire will die) and defending your lairs. If you are attacking a Templar Stronghold and either a lab or a drone appears, go destroy that immediately, you can come back to a Templar base, they don't heal too quickly.

If you don't manage to destroy lab before it is fully operational and goes blue, reload the last save. Remember to let your vampire heal in the lairs in between fights if needed.

From this point, any time you stop in a country, you'll want to use Blood Rage in that country, to greatly increase infection rates, as well as destroying anything there that you don't want. When you have the DNA available, evolve the following;

Adrenal Surge

Dark Infiltration

Travel to the base that is farthest from your lairs and destroy it. I'd suggest creating a new save here. Remember to let your vampire heal afterwards. Continue to evolve;

Malignant Pigmentation

Lair Healing 1

Shadow Blades

Find the base that is now second farthest from you and destroy that one. I'd suggest creating a new save here as well. Continue evolving;

Hypersensitivity

Dark Pustules

Latent Adaptation

Muscular Hypotrophy

Masticatory Tension

Lair Healing 2

Now you want to be taking out the final two Templar strongholds simultaneously. Travel to the second closest to your lairs and take it down to around 10% health. Teleport to near the other stronghold and destroy that one completely. Then head back to the weakened base and destroy that as well. This should deal with all the Templar strongholds.

Now simply to deal with the remaining labs and the rest of the world. Travel to the countries that are not fully infected yet and deploy use your Blood Rage in that country, prioritising countires that are listed as the key contributors to cure research. Travel around the remaining countries and wipe them all out using this method. For added effect, if you have DNA points spare you can evolve;

Blood Sacrifice 1

Dermal Calcification

Blood Sacrifice 2

These will all help wipe out humanity quicker.

After wiping out the Earth with the help of your Shadow Slaves, you will have finished the final plague for this scenario and will pop;

Super Sparrow

Get 3 biohazards with each disease on normal or higher in the Pirate Plague Scenario

Super Sparrow
1 guideOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Shut Down Everything

Use the same as above for the special plagues (Fungus, Necroa, Simian Flu, Shadow Plague) but for everything else, use the set-up below. Obviously, with Nano-Virus you'll want to use your Overload and jammers to block the cure, and for Bio-Weapon get your Annihilation Gene. Start with:

ATP Boost
Darwinist
Aquacyte
Urbophile
Trans-Stasis

Start in China and evolve:

Rodent I
Livestock I
Bird I and II
Water I
Air I
Water II
Air II
Extreme Bioaerosol
Cold Resistance I and II
Drug Resistance I and II
Heat Resistance I
Blood I
Internal Hemorrhaging
Hemorrhagic Shock
Total Organ Failure

After completing these, you'll get:

Mr President

Get 3 biohazards with each disease on normal or higher in the Shut Down Everything Scenario

Mr President
4 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Volcanic Ash

Same Simian strategy works here, as well as fungus since the ash doesn't stop the spread of spores. The shadow Plague solution above also works here, just switch your Aerocyte gene for the Teracyte gene and follow as that previous solution as normal.

As for every other regular scenario use:

ATP Boost
Darwinist
Teracyte
Extremophile
Sympto-Stasis

Start in India and evolve:

Livestock I
Rash
Sweating
Skin Lesions
Water I
Bird I and II
Water II
Coughing
Sneezing
Pneumonia
Cysts
Abscesses
Cold Resistance I and II
Drug Resistance I
Nausea
Vomiting
Diarrhea
Insect I
Blood I
Rodent
Drug Resistance II

Once your infection rate is high, evolve:

Necrosis
Dysentery
Total Organ Failure
Hemorrhagic Shock
Internal Hemorrhaging

Reshuffle your way to victory. As before, use the disease specific abilities like Overload and Annihilation Gene for those playthroughs.

For Necroa change Aerocyte to Aquacyte and Xerophile to Rurophile. Start in India as opposed to Saudi Arabia. Evolve:

Zoonotic Shift
Hyper Salivation
Bat I and II

Wait for Polyphagia to mutate. If it doesn't when the mutation occurs, restart and try again. Once it does, SAVE and evolve:

Gastroenteritis
Autophagia
Bird I
Drug Resistance I

Wait for Cannibalism to mutate. If it doesn't, load your save and get to this point until it does and SAVE again. Once India is fully infected, wait for the infection to reach the United States. If it takes too long, load your save. Evolve Zombie Horde and every single upgrade for it, especially making sure to pick up Drifting Fermentation. Drag a population of zombies to Brazil for access to South America. Evolve:

Acidic Reflux
Naja Mortis
Autothysis
Lumbrical Hypertrophy
Adrenal Surge
Hyperosmia
Temporal Lobe Manipulation
Enhanced Sensory Integration
Cathemeral Shift
Vampire Hunger

Use your abilities to make your zombies powerful, migrating hordes to all the islands of the world and infecting everything. Focus on destroying Z-Com rapidly to make things go faster and keep the cure down. This one is very hard, but you will eventually prevail and earn:

Lava God

Get 3 biohazards with each disease on normal or higher in the Volcanic Ash Scenario

Lava God
2 guidesOffline Game Mode - These achievements require play in game modes that do not necessitate a connection to any online services.Single Player - These achievements can be obtained by a single player.Difficulty Specific - These achievements require that the game be played on a certain difficulty level.

Congratulations on completing Plague Inc: Evolved! This game has tough moments and certainly takes perseverance, so this is one for the trophy case. I'd once again like to thank the members of the TA community for their solutions and inputs to this guide, the people over on the Steam forums for their contributions, as well as the content creators on Yo! It's Spicy. Couldn't have done this without you all.

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